HOME >> BIOLOGY >> NEWS
Software Helps Decipher Genomes Of Higher Organisms

A software program that has been successfully annotating the genes of common bacteria since 1992 is now capable of finding genes in higher organisms. It is particularly useful for finding human genes in anonymous human DNA sequences.

Understanding the genomes of key microorganisms may increase understanding of human genetics because lower organisms have some genes that correspond to human genes. Also scientists can design new drugs based on knowledge of disease-causing bacteria.

The original software program, called GeneMark, uses probabilistic mathematical models to predict the locations of genes on a strand of DNA. GeneMark was developed by Dr. Mark Borodovsky, a professor of biology at the Georgia Institute of Technology. It has become the world's most-used software program for deciphering bacterial DNA and has proven itself 98 percent accurate.

Borodovsky's latest development uses GeneMark.hmm, a refined version of the original program, as its base to make more sophisticated predictions for the genomes of eukaryotic, or higher organisms.

"Deciphering bacterial DNA is simpler than deciphering human DNA since its genes run continuously, without gaps," Borodovsky explained. "The genes of human DNA may be divided into pieces, called exons, with non-coding genetic material between the exons. These spacers in the genes, called introns, were hard to detect by a computer algorithm. Also, eukaryotic DNA is much longer, with an average gene size of 10,000 nucleotides."

Therefore, the predictions of where eukaryotic genes lie on a strand of DNA must include predictions of the boundaries between the exons, which contain the genetic information, and introns, which are the non-coding regions.

To create a computer program to achieve this, Borodovsky employed a probabilistic mathematical model called Hi
'"/>

Contact: Jane Sanders
jane.sanders@edi.gatech.edu
404-894-2214
Georgia Institute of Technology Research News
1-Dec-1998


Page: 1 2 3 4

Related biology news :

1. 5AM Solutions releases Microarray Enterprise Manage(TM) Software
2. Software tackles protein pathways
3. Software to make testing of new generic drugs more thorough
4. New Software Provides Quick Analysis of ion-Channel Activity
5. Nutrition Therapy Helps Patients Emotionally, Research Shows
6. ASU Professor Helps In Fight To Protect Japanese Pika Habitat
7. Whitehead Study Supports Existence Of Ancient RNA World, Helps Provide Insight Into Early Evolution Of Life
8. Duke Study Helps Explain How Cells Divvy Up Genes During Reproduction
9. Transplanted Skeletal Muscle Mimics Heart Muscle; Helps Failing Heart Pump, Duke Researchers Say
10. Security Code Helps Immune Cells Attack Foe And Spare Self
11. NASA Research Helps Map Protein Structures -- Key In The Development Of New Disease-Fighting Drugs

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: