HOME >> BIOLOGY >> NEWS
Some 400 'fragile regions' of genome more vulnerable to evolutionary breaks

San Diego, June 16, 2003 -- Researchers from the University of California, San Diego (UCSD) Jacobs School of Engineering have uncovered evidence that major evolutionary changes are more likely to occur in approximately 400 'fragile' genomic regions that account for only 5 percent of the human genome. The findings, reported in the June 24 issue of the Proceedings of the National Academy of Sciences (PNAS), undercut the widely held view among scientists that evolutionary breakpoints -- disruptions in the order of genes on chromosomes -- are purely random. Apart from its implications for evolutionary theory, the study could have major implications for medical research related to diseases such as leukemia, which are caused by clinical (rather than evolutionary) chromosomal breakpoints.

"These rearrangements are like earthquakes that are more likely to happen along fault lines, which is why you're more likely to see a quake in Los Angeles than Chicago," said Pavel Pevzner, the Ronald R. Taylor Chair in the Jacobs School's Computer Science and Engineering department, who co-authored the study with project scientist Glenn Tesler. "Similarly, there are 'faults' within the human genome. They are fragile regions, as opposed to solid regions that show much less propensity for rearrangement and make up about 95 percent of the genome."

Pevzner and Tesler are experts in bioinformatics -- the use of computing and mathematics to study genomes -- and their study grew out of the first giant genomic sequencing projects, funded in part by the National Institutes of Health. Those projects resulted in DNA sequencing of the human and mouse genomes. In December 2002, that comparison led the scientists to compute 281 large blocks (of one million 'letters' or more, out of roughly three billion letters in the mammalian genome), and 245 major rearrangements since the two species evolved from a common ancestor 75 million years ago. "Like the ancient super-continent Pangea broke
'"/>

Contact: Doug Ramsey
dramsey@ucsd.edu
858-822-5825
University of California - San Diego
16-Jun-2003


Page: 1 2 3

Related biology news :

1. Scientists sequence genome of kind of organism central to biospheres carbon cycle
2. Keep genome data freely accessible
3. The book opens on the first tree genome
4. NSF awards 22 new projects for plant genome research
5. Milk genome symposium
6. Environmental decontamination, greenhouse gases, and the genome of a methane-loving bacterium
7. Scientists explore genome of methane-breathing microbe
8. National Academies advisory: genome data and bioterrorism
9. Adaptive changes in the genome may provide insight into the genetics of complex disease
10. Complex cells likely arose from combination of bacterial and extreme-microbe genomes
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/19/2016)... TORONTO , 19 de diciembre de 2016  Mosaic ... permitirá el desarrollo acelerado de MSC-1, un anticuerpo humanizado que se ... tumor en 2017, con múltiples sitios previstos a lo largo de ... ... el factor inhibidor de leucemia (LIF), una citoquina pleiotrópica que se ...
(Date:12/16/2016)... 2016 Research and Markets has announced the ... Forecast to 2021" report to their offering. ... The biometric vehicle access system ... CAGR of 14.06% from 2016 to 2021. The market is estimated ... reach 854.8 Million by 2021. The growth of the biometric vehicle ...
(Date:12/15/2016)... and BADEN-BADEN, Germany , December 15, ... global financial services provider, today announced an agreement with NuData ... biometrics, to join forces. The partnership will enable clients to ... in compliance with local data protection regulation. ... In order to provide ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... and HOUSTON , Jan. ... Prenatal") today announced the formation of its Medical/Clinical ... clinicians and industry veterans who enhance the range ... it accelerates development of its novel prenatal diagnostic ... medical, clinical and strategic guidance for the company,s ...
(Date:1/19/2017)... , ... January 19, 2017 ... ... advanced software solutions for pharmaceutical research and development (R&D), today announced the ... omic data analysis and interpretation for the rapidly evolving field of precision ...
(Date:1/19/2017)... 19, 2017  ArmaGen, Inc., today announced that ... as chief executive officer, as well as a ... to ArmaGen more than 17 years of executive ... of biotherapeutics and pharmaceuticals. "Mathias ... experience and skillset necessary to lead ArmaGen to ...
(Date:1/19/2017)... ... January 18, 2017 , ... LabRoots ... scientists from around the world, was today awarded the "Best Science & Technology ... entirely on merit and decided upon by a dedicated team of researchers and ...
Breaking Biology Technology:
Cached News: