"These rearrangements are like earthquakes that are more likely to happen along fault lines, which is why you're more likely to see a quake in Los Angeles than Chicago," said Pavel Pevzner, the Ronald R. Taylor Chair in the Jacobs School's Computer Science and Engineering department, who co-authored the study with project scientist Glenn Tesler. "Similarly, there are 'faults' within the human genome. They are fragile regions, as opposed to solid regions that show much less propensity for rearrangement and make up about 95 percent of the genome."
Pevzner and Tesler are experts in bioinformatics -- the use of computing and mathematics to study genomes -- and their study grew out of the first giant genomic sequencing projects, funded in part by the National Institutes of Health. Those projects resulted in DNA sequencing of the human and mouse genomes. In December 2002, that comparison led the scientists to compute 281 large blocks (of one million 'letters' or more, out of roughly three billion letters in the mammalian genome), and 245 major rearrangements since the two species evolved from a common ancestor 75 million years ago. "Like the ancient super-continent Pangea broke
Contact: Doug Ramsey
University of California - San Diego