HOME >> BIOLOGY >> NEWS
Some women may have gene sequence that reduces breast cancer risk, SFVAMC study finds

Some postmenopausal women carry a gene sequence that may lower their risk of breast cancer, according to new research from San Francisco Veterans Affairs Medical Center. The intriguing results must be repeated and explored further before they will be of practical use in breast cancer medicine, the researchers said.

In the study, about fifteen percent of the women carried a particular sequence in the gene for the growth factor TGF-beta-one. This group also had a 60 percent lower risk of breast cancer, according the paper published in the Wednesday, June 12 issue of the Journal of the American Medical Association.

"It's a really interesting finding, because it fits with previous research in mice that showed TGF-beta might play a role in breast cancer," said lead author Elad Ziv, MD, postdoctoral fellow in general internal medicine at SFVAMC and University of California, San Francisco.

But he cautions that the study does not indicate how the protective effect might work, or whether it could be useful in fighting the disease. "I want to stress that the research is still at the early stages, and we are far away from any applications such as breast cancer tests or treatments," Ziv said.

The researchers studied more than 3000 white, post-menopausal women who had participated in a study on osteoporosis. Using blood samples the women had donated, Ziv and his colleagues generated a DNA sequence for part of the gene for TGF-beta, a protein which inhibits the growth of breast tissue and controls growth of other types of cells.

Artificially increasing TGF-beta levels in mice can protect them against breast tumors, earlier studies have shown.

Another previous study showed that people with a particular TGF-beta-one sequence, or genotype, had higher levels of TGF-beta-one. People with a C/C genotype, meaning a cytosine (C) base pair at position 29 on both of their copies of the TGF-beta-one gene, had the higher levels of TGF-be
'"/>

Contact: Kevin Boyd
kboyd@pubaff.ucsf.edu
415-476-8429
University of California - San Francisco
11-Jun-2001


Page: 1 2

Related biology news :

1. Far more men than women favor routine paternity testing at birth
2. Folic acid vitamin use by women reaches all-time high, March of Dimes survey finds
3. Alcohol-use and depression among pregnant and postpartum women
4. More aggressive breast cancer tumors found in African American women
5. New study confirms process leading to disorder causing male characteristics in women
6. Gestational diabetes not found to alter the metabolic processes in obese pregnant women
7. Why lung cancer in women is different from men
8. With fat, women have a more visceral response
9. NASA-inspired technology may help preserve womens future fertility after cancer treatment
10. New research finds summer-born women have fewer children
11. New studies show Curves Program raises metabolic rate in overweight and sedentary women

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/1/2020)... N.J. (PRWEB) , ... July 01, 2020 , ... ... announced that it had completed the purchase of Teva-Takeda Pharmaceuticals’ packaging facility in ... the company’s existing Japanese clinical supply facility located in Kakegawa, the new 60,000-square-foot ...
(Date:6/25/2020)... ... June 24, 2020 , ... eClinical Solutions LLC , ... that accelerate drug development, is collaborating with Karyopharm Therapeutics (Nasdaq: KPTI ) ... with severe COVID-19. This is the first study of an XPO1 inhibitor in ...
(Date:6/23/2020)... , ... June 23, 2020 , ... ... is pleased to announce the next event in a series of TOPIQ webinars, ... The TOPIQ series of webinars was developed in response to social distancing measures ...
Breaking Biology News(10 mins):
(Date:7/1/2020)... , ... June 30, 2020 ... ... tissue data insights, today announced that the launch of a new ... with data about the tumor microenvironment (TME). , “Flagship’s TissueInsight is a ...
(Date:6/28/2020)... ... June 26, 2020 , ... The Security Industry Association ... strong opposition to the recently introduced bicameral Facial Recognition and Biometric Technology ... federal use of nearly all biometric and related image analytics technologies, incorrectly labeling ...
(Date:6/23/2020)... ... June 22, 2020 , ... Dracen Pharmaceuticals Inc., announced ... June 22-24 during the American Association for Cancer Research Virtual meeting. One poster ... potent, consistent single agent activity in KEAP1 mutant tumor models of NSCLC. ...
(Date:6/11/2020)... , ... June 09, 2020 , ... ... Phase I of a Small Business Innovation Research (SBIR) program funded by the ... Century: Rapid Toxin Detection in the Field”. The project’s goal was to engineer ...
Breaking Biology Technology:
Cached News: