HOME >> BIOLOGY >> NEWS
Specific gene mutations responsible for congenital heart defects

DALLAS July 6, 2003 Researchers at UT Southwestern Medical Center at Dallas have discovered a gene critical to the development of the human heart and that mutations in the gene lead to congenital heart defects the leading noninfectious cause of death in newborns.

GATA4 is only the second gene to have been identified as a cause of isolated congenital heart disease not associated with medically identified syndromes.

The findings will be published in a future edition of the journal Nature and appear online today.

The researchers identified mutations in the gene GATA4 as a cause of human cardiac septal defects, which occur when the walls separating the heart's four chambers do not form properly.

"In terms of identifying genetic etiologies, there are not many discoveries that have been made," said Dr. Vidu Garg, assistant professor of pediatrics and one of the study's lead authors. "This is one of the genes responsible, and we are working to identify others."

This discovery could one day help doctors prevent congenital heart defects the most common developmental anomaly by fixing the problem before a baby is born, said Dr. Deepak Srivastava, associate professor of pediatrics and molecular biology and the study's senior author.

"We cannot change the fact that parents are going to pass along the mutation, but we might be able to develop a way to keep the disease from occurring," said Dr. Srivastava.

In the Nature study, researchers from UT Southwestern and three Japanese medical institutions examined two large families: one in Dallas that spanned five generations and included 16 members suffering from congenital heart defects, and a family from Tokyo spanning four generations and with eight members with congenital heart defects.

UT Southwestern researchers and Dr. Rumiko Matsuoka, a pediatric cardiologist from Japan, gathered data from the families' medical history. Researchers also condu
'"/>

Contact: Staishy Bostick Siem
staishy.siem@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
6-Jul-2003


Page: 1 2 3

Related biology news :

1. UB Researchers Identify Specific Oral Bacteria Most Likely To Increase Risk Of Heart Disease
2. Vions TAPET Organisms Demonstrate Reduced Virulence, Increased Safety While Retaining Ability To Specifically Target Tumors
3. Sex-Specific Behavior Controlled By Peripheral Nervous System
4. Fred Hutchinson Cancer Research Center And Targeted Genetics Announces Issuance Of Braod Patent Covering Antigen-Specific T Cell Expansion
5. New Tests Demonstrate MuchLarger, More Specific Immune Responses To Viruses
6. Mouse Model Of Down Syndrome Offers Glimpse Into Role Of Specific Genes In TheDisorder
7. Novel AIDS-Directed Technology: Approach Permits Optimization Of Existing Drug Therapies And Targeted, Patient-Specific Treatment
8. Genetic mutations linked to the practice of burning coal in homes in China
9. Rare mutations can significantly increase risk factor for heart disease
10. The mother lode of mutations
11. Mastectomy dramatically reduces breast cancer risk among women with BRCA1/2 mutations

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2017)... and ITHACA, N.Y. , June 23, ... University, a leader in dairy research, today announced a ... to help reduce the chances that the global milk ... of this dairy project, Cornell University has become the ... the Food Supply Chain, a food safety initiative that ...
(Date:5/16/2017)... 16, 2017  Veratad Technologies, LLC ( www.veratad.com ), ... and identity verification solutions, announced today they will participate ... May 15 thru May 17, 2017, in ... Trade Center. Identity impacts the lives ... today,s quickly evolving digital world, defining identity is critical ...
(Date:4/24/2017)... 24, 2017 Janice Kephart , ... Identity Strategy Partners, LLP (IdSP) , today issues ... President Trump,s March 6, 2017 Executive Order: ... vetting can be instilled with greater confidence, enabling ... all refugee applications are suspended by until at ...
Breaking Biology News(10 mins):
(Date:9/19/2017)... Washington, D.C. (PRWEB) , ... September 19, 2017 ... ... care during an biological outbreak is about to be eliminated, said Lyle Probst, ... makes ExcitePCR’s FireflyDX™ technologies different than other pathogen detection solutions, Probst ...
(Date:9/19/2017)... , ... September 19, 2017 , ... ... technologies for surgical applications, announced today that two new patents have been allowed ... Albert, MD, Co-Founder of Band-LOK, said, “We continue to explore additional clinically-relevant designs ...
(Date:9/17/2017)... ... September 17, 2017 , ... GeneOne Life Science, ... Food and Drug Safety (KMFDS) for an Investigational New Drug application for a ... Syndrome coronavirus (MERS-CoV). The study in Korea represents the second clinical trial for ...
(Date:9/14/2017)... ... September 14, 2017 , ... Boston ... extensive experience with Health Economics and Outcomes Research (HEOR) and ‘big data’ to ... In 2014, US healthcare spending exceeded $3.0 trillion with nearly 1/3 spent on ...
Breaking Biology Technology:
Cached News: