HOME >> BIOLOGY >> NEWS
Sperm Protein May Hold Clues For Fertility And Contraceptives

A protein found on the surface of the sperm of all mammals appears crucial for the union of the sperm and egg, as well as for movement of the sperm into the animal's oviduct, announce researchers at the University of California, Davis.

The discovery, which has direct implications for human fertility research as well as development of male contraceptives, is reported in the Sept. 18 issue of the journal Science.

"We suspected that sperm lacking the protein known as fertilin-beta would not be able to penetrate the egg, but we were quite surprised that these sperm even failed to bind with the egg's outer coating and rarely were able to travel from the uterus to the oviduct," said researcher Chunghee Cho. He is a molecular biologist and postdoctoral fellow from Korea working in the laboratory of UC Davis fertility researchers Diana Myles and Paul Primakoff.

The researchers studied the activity of sperm in mice lacking the gene for fertilin-beta, which belongs to a family of proteins found on the surface of cells and is believed to be important in cell binding.

Sperm from the mutant mice looked and moved normally, but most of them failed to attach to the egg. These sperm fused with the plasma membrane, which encases the egg, at just half the rate of sperm from normal mice.

Cho and colleagues anticipated this binding failure at the plasma membrane, but were surprised that the defective sperm were not even binding with the zona pellucida, the thick transparent wall that forms the outermost covering of the egg.

Furthermore, the sperm lacking fertilin-beta seemed unable to migrate from the uterus into the oviduct where the eggs are housed. The researchers speculate that this may be because the mutant sperm were unable to temporarily cling to the lining of the juncture of the uterus and oviduct as they normally would before proceeding into the oviduct.

The fertility rate of the male mice lacking fertilin-beta was 98 percent less than that of the no
'"/>

Contact: Patricia Bailey
pjbailey@ucdavis.edu
(530) 752-9843
University of California - Davis
17-Sep-1998


Page: 1 2

Related biology news :

1. Sperm use heat sensors to find the egg
2. Sperm and germ-fighting contraceptive enters trials
3. Sperm counts unchanged over 50 years
4. Male Moths Sperm Protects Females
5. Eggs Fertilised By More Than One Sperm Can Survive
6. Gene Once Thought To Program Ovarian Development Instead Found To Be Critical For Production Of Sperm
7. Bacteria That Disable Sperm
8. UB Fertility Researchers Find They Can Predict Pregnancy By Assessing Two Sperm Abnormalities
9. The First Rejection: Eggs Sequester Bits Of Sperm For Later Elimination
10. Reanalysis Of International Data Finds Sharp Decline In Sperm Density
11. Stress Lowers Sperm Count By Overwhelming Cells That Make Testosterone

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/6/2019)... ... June 05, 2019 , ... Ziegler, ... financial advisor to Pathologists Bio-Medical Laboratories (PBM) on its recent acquisition by PathGroup. ... platform that provides services to more than one dozen hospitals and surgery centers ...
(Date:6/4/2019)... ... June 04, 2019 , ... Harper was three years old when ... severe elbow dysplasia, which caused painful osteoarthritis in the joints. She was referred ... were heartbroken. , The surgical specialist, Dr. Christopher Eich of Southern California Veterinary ...
(Date:6/3/2019)... ... 2019 , ... Stay on top of current hot topics through free webinars ... all webinars is free, so be sure to register today to save your place! ... to see our upcoming webinars: , CLINICAL TRIALS , June 10 – A ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... ... June 11, 2019 , ... A study ... stem cells (MSC-EV) are able to incorporate into human CD34+ cells, modifying their ... mice, MSC-EVs also increased the cells’ ability to lodge into bone marrow. This ...
(Date:5/31/2019)... ... May 30, 2019 , ... Object Pharma, ... the strategic acquisition of Metabiologics, Inc., a globally recognized leader in the production ... and commercialization rights to a full spectrum of botulinum neurotoxins, as well as ...
(Date:5/15/2019)... ... 16, 2019 , ... Emulsifiers are the magic bullet when ... rely on these ingredients to create stable quality food that can withstand shelf-life ... triggers food formulators to seek out alternatives for starches, gums and chemical emulsifiers. ...
(Date:5/4/2019)... ... May 03, 2019 , ... More than three thousand ... Association, the scientist and ufologist Urandir Fernandes de Oliveira, last Thursday (25), during ... results of some research carried out by the association, in partnership with scientists ...
Breaking Biology Technology:
Cached News: