HOME >> BIOLOGY >> NEWS
Sperm Protein May Hold Clues For Fertility And Contraceptives

A protein found on the surface of the sperm of all mammals appears crucial for the union of the sperm and egg, as well as for movement of the sperm into the animal's oviduct, announce researchers at the University of California, Davis.

The discovery, which has direct implications for human fertility research as well as development of male contraceptives, is reported in the Sept. 18 issue of the journal Science.

"We suspected that sperm lacking the protein known as fertilin-beta would not be able to penetrate the egg, but we were quite surprised that these sperm even failed to bind with the egg's outer coating and rarely were able to travel from the uterus to the oviduct," said researcher Chunghee Cho. He is a molecular biologist and postdoctoral fellow from Korea working in the laboratory of UC Davis fertility researchers Diana Myles and Paul Primakoff.

The researchers studied the activity of sperm in mice lacking the gene for fertilin-beta, which belongs to a family of proteins found on the surface of cells and is believed to be important in cell binding.

Sperm from the mutant mice looked and moved normally, but most of them failed to attach to the egg. These sperm fused with the plasma membrane, which encases the egg, at just half the rate of sperm from normal mice.

Cho and colleagues anticipated this binding failure at the plasma membrane, but were surprised that the defective sperm were not even binding with the zona pellucida, the thick transparent wall that forms the outermost covering of the egg.

Furthermore, the sperm lacking fertilin-beta seemed unable to migrate from the uterus into the oviduct where the eggs are housed. The researchers speculate that this may be because the mutant sperm were unable to temporarily cling to the lining of the juncture of the uterus and oviduct as they normally would before proceeding into the oviduct.

The fertility rate of the male mice lacking fertilin-beta was 98 percent less than that of the no
'"/>

Contact: Patricia Bailey
pjbailey@ucdavis.edu
(530) 752-9843
University of California - Davis
17-Sep-1998


Page: 1 2

Related biology news :

1. Sperm use heat sensors to find the egg
2. Sperm and germ-fighting contraceptive enters trials
3. Sperm counts unchanged over 50 years
4. Male Moths Sperm Protects Females
5. Eggs Fertilised By More Than One Sperm Can Survive
6. Gene Once Thought To Program Ovarian Development Instead Found To Be Critical For Production Of Sperm
7. Bacteria That Disable Sperm
8. UB Fertility Researchers Find They Can Predict Pregnancy By Assessing Two Sperm Abnormalities
9. The First Rejection: Eggs Sequester Bits Of Sperm For Later Elimination
10. Reanalysis Of International Data Finds Sharp Decline In Sperm Density
11. Stress Lowers Sperm Count By Overwhelming Cells That Make Testosterone

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/21/2016)... VANCOUVER, British Columbia , June 21, 2016 ... been appointed to the new role of principal ... has been named the director of customer development. ... , NuData,s chief technical officer. The moves reflect ... development teams in response to high customer demand ...
(Date:6/9/2016)... 9, 2016 Paris Police ... video security solution to ensure the safety of people and ... during the major tournament Teleste, an international technology ... services, announced today that its video security solution will be ... back up public safety across the country. The system roll-out ...
(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, ... Infrastructure, Support & Other Service  The latest ... comprehensive analysis of the global Border Security market ... of $17.98 billion in 2016. Now: In ... in software and hardware technologies for advanced video surveillance. ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. Hoffmann, ... faculty of the University of North Carolina Kenan-Flagler Business School effective ... at UNC Kenan-Flagler, with a focus on the school’s international efforts, leading classes ...
(Date:6/27/2016)... BOSTON , June 27, 2016   Ginkgo ... biology to industrial engineering, was today awarded as ... a selection of the world,s most innovative companies. ... at scale for the real world in the ... organism engineers work directly with customers including Fortune ...
(Date:6/24/2016)... SAN DIEGO , June 24, 2016 /PRNewswire/ ... that more sensitively detects cancers susceptible to PARP ... individual circulating tumor cells (CTCs). The new test ... of HRD-targeted therapeutics in multiple cancer types. ... therapies targeting DNA damage response pathways, including PARP, ...
(Date:6/24/2016)... ... , ... Researchers at the Universita Politecnica delle Marche in Ancona combed medical ... mesothelioma. Their findings are the subject of a new article on the Surviving Mesothelioma ... in the blood, lung fluid or tissue of mesothelioma patients that can help point ...
Breaking Biology Technology:
Cached News: