Spider Venom Stops Stroke Brain Damage

ANAHEIM, Calif. -- A new chemical isolated from spider venom might one day prevent human brain cells from dying after being deprived of oxygen for short periods, a Cornell University chemist believes.

In a talk today (March 23) at the American Chemical Society national meeting at the Anaheim Hilton, Jerrold Meinwald, professor of chemistry biology noted that smoke-inhalation or stroke can cause overproduction of amino-acid neurotransmitters, possibly resulting in brain damage. "What this venom could do is block the effect of the overproduction of some of the neurotransmitters," he said. "In effect, we're turning off the receiver."

The new neuroactive chemical, known as HF-7, was originally isolated from the venom of the funnel-web spider, Hololena curta. The work was a collaboration of chemists at Cornell, Leiden University in the Netherlands, and Cambridge Neuroscience, Inc., a pharmaceutical firm in Cambridge, Mass.

Until the discovery of HF-7, it was thought that all spider venom components were amino-acid based. However, this venom is based on a nucleic acid building block, Meinwald said: "It was a genuine surprise. We had no idea at all that this toxin was made from a nucleic acid component."

Describing his search for this neuroactive chemical, Meinwald said, "Looking for a needle in a haystack is easier. There you just get a big magnet and you'll find it. Looking for this chemical, we didn't know what we'd find. We didn't know what kind of structure we were looking for."

HF-7 works in the brain by blocking one in a family of receptor molecules called kainate receptors, which act as gates in nerve cell membranes. Theoretically, during short bouts of oxygen loss, HF-7 should stave off severe brain damage. However, Meinwald said, it is not clear if the synthesized venom can break through the blood-brain barrier.

In a forthcoming chemical journal article, Meinwald and his coworkers will describe both the structure and sy

Contact: Blaine P. Friedlander, Jr.
Cornell University News Service

Page: 1 2

Related biology news :

1. Spiders or scapegoats
2. Spiders make best ever Post-it notes
3. Spiders get better web sites by rising early
4. Goats And Spiders Are Working Together To Create A Novel Material
5. Venom hunt finds harmless snakes a potential danger
6. Venomous dinosaurs really existed
7. Cousin Of Snake Venom Toxin Found In Mice
8. Experimental Drug Derived From Snake Venom Shows Promise In Reversing Effects Of Stroke
9. Snake Venom Slows Tumor Growth
10. Salve From Serpents? UD Studies May Explain Why Viper-Venom Protein Stops Tumor Spread In Mice
11. Heat-Shock Vaccine Stops Bacteria Dead

Post Your Comments:

(Date:6/23/2020)... ... June 23, 2020 , ... ... and Renovagen Ltd, a UK supplier and manufacturer of innovative portable renewable energy ... operations in the fight against the COVID-19 pandemic in Zambia. , One of ...
(Date:6/23/2020)... BOSTON (PRWEB) , ... June 23, 2020 , ... In ... feature interview with Dr. James L. Sherley, M.D., Ph.D., founder and director ... after the company announced on June 16 that starting July 5 it ...
(Date:6/19/2020)... ... June 18, 2020 , ... Join experts from ... Principal Scientist in a live webinar on Wednesday, July 8, 2020 at ... the way we genetically engineer new models. However, while modifying the genome may be ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... LEXINGTON, Ky. (PRWEB) , ... August 03, 2020 , ... ... innovative products for transformative growth, , Known as MediVet Biologics ... Health brand. , The new Ardent Animal Health will build on its ...
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON ... of its new tagline, “BUILDING FOR LIFE.” The adoption of this taglines comes ... globe, requiring fast track capacity to provide patients with urgently needed vaccines and ...
(Date:7/31/2020)... ... July 29, 2020 , ... Anomet Products has introduced new ... for use with CRM, neurostimulation, vascular, and related devices. , Anomet Medical ... requirements, performance, and cost criteria; especially where solid wire is limited. Typical configurations ...
(Date:7/31/2020)... ... 29, 2020 , ... eSource has long been touted as the solution to ... of eSource, the reasons it did not take off as quickly as people initially ... industry is moving towards capturing data electronically for clinical trials and then repurposing it ...
Breaking Biology Technology:
Cached News: