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Sponge substance works well with yew derivative to thwart cancer cell proliferation

A drug derived from an ocean-growing sponge teams up to enhance the performance of the yew tree derivative Taxol (paclitaxel) in preventing the growth of cancer cells, according to research published in the July 15 issue of the journal Cancer Research.

Indeed, discodermolide, a novel drug isolated from the marine sponge Discodermia dissoluta, works with paclitaxel to thwart tumor cell growth--with several times the efficacy that either drug alone exerts on proliferating cancer cells.

Studies by Mary Ann Jordan, Ph.D., a scientist at the University of California, Santa Barbara, and an international team of cancer researchers including postdoctoral fellows Stephane Honore, Ph.D., and Kathryn Kamath, Ph.D., demonstrate that the combination of the two drugs inhibited proliferation of human lung cancer cells by 41 percent. Administered alone, either discodermolide or paclitaxel prevented the cancer cell growth by only 9.6 or 16 percent, respectively. The drugs also combined to induce programmed cell death, or apoptosis, in the lung cancer cells.

"Our results indicate that Taxol and discodermolide have the potential to improve cancer patients' responses and reduce undesirable side effects when the two drugs are administered together," Jordan said.

The drugs, which stem from naturally occurring sources, work in concert to stabilize the assembly/disassembly process of microtubules in cells. Microtubules--lengthy polymers made up of protein bundles, called tubulin--form long, straw-like cylinders that help shape the skeletal structure within cells and also move cellular components within the cell, including vesicles, granules, organelles like mitochondria, and chromosomes. Their attachment with chromosomes, the DNA genetic material in cells, is critical for cell replication and growth. Microtubules normally exist in a state of dynamic instability, where the polymers grow rapidly--longer or shorter, depending on the need of the cells.
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Contact: Russell Vanderboom
vanderboom@aacr.org
215-440-9300
American Association for Cancer Research
15-Jul-2004


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