HOME >> BIOLOGY >> NEWS
Spun from bone

RICHLAND, Wash. Bone and enamel start with the same calcium-phosphate crystal building material but end up quite different in structure and physical properties.

The difference in bone and enamel microstructure is attributed to a key protein in enamel that molds crystals into strands thousands of times longer and much stronger than those in bone. The dimension of an enamel strand is 100,000 by 50 by 25 nanometers; bone is 35 by 25 by 4 nanometers.

But how that protein achieves this feat of crystal-strand shape-shifting has remained elusive. Today, scientists have reported the first direct observation of how this protein, amelogenin, interacts with crystals like those in bone to form the hard, protective enamel of teeth.

The study, published by a team from the Department of Energys Pacific Northwest National Laboratory and the University of Southern California on Friday (Sept. 24) in Journal of Biological Chemistry, identifies the region of the protein that interacts with the enamel crystals. The results explain how 100 nanometer spheres of amelogenin cluster like bowling balls around developing enamel crystals, forcing the crystals to elongate into thin, weaved strands that endow enamel with the strength of steel.

The discovery is a milestone for those who would wish to nano-engineer tissues, implants and synthetic coatings based on natures rules.

The proteins determine the crystal structure, said Wendy J. Shaw, lead author and PNNL staff scientist. Like bone, teeth are made of HAP, but the proteins present when teeth form create enamel, a material with entirely different properties from bone. If you can control the interactions between proteins and crystals, the same principal can be applied to nano-patterning and nano-building.

Shaws co-authors are PNNL chief scientist Allison A. Campbell and Michael L. Paine and Malcolm L. Snead of USCs Center for Craniofacial Molecular Biology in Los Angeles.

Earlier stud
'"/>

Contact: Bill Cannon
cannon@pnl.gov
509-375-3732
DOE/Pacific Northwest National Laboratory
24-Sep-2004


Page: 1 2

Related biology news :

1. Rutgers anthropologist, Fossey Fund official, announces plan to save Rwandas mountain gorillas
2. UMass anthropologist investigates dental development and body size in primates
3. Gladstone investigator Mike McCune wins prestigious NIH Directors Pioneer Award
4. UT Southwestern biochemist honored with NIH Directors Pioneer Award
5. Award winning researchers reveal potential new role for Glivec
6. Secretary of Energy announces seven E.O. Lawrence Award Winners
7. Martin Saunders to receive the James Flack Norris Award
8. Berkeley Lab soil scientist Margaret Torn receives Presidential Early Career Award
9. NJIT professor receives Presidential Award for breakthrough research with adult stem cells
10. Second call for proposals for the European Young Investigator Award
11. Virginia Tech professor honored with DeLaval Award

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Spun from bone

(Date:11/3/2014)... Colorado Cancer Center study published in this ... describes the activity of a recently discovered communication ... IL-37. It has been known to limit inflammation and ... immune system: IL-37 inhibits the ability of the immune ... this mechanism that underlies IL-37,s effect on the immune ...
(Date:11/3/2014)... that low birth weight and preterm birth are linked ... adulthood. Findings published in the American College of Rheumatology ... that low birth weight and pre-term babies were not ... as adults. , According to the ACR, 27 ... with clinical OA. Symptoms of OA range from mild ...
(Date:11/2/2014)... of a bold quest to rid the world entirely ... announced an award of US$156 million to PATH to ... new vaccines that will interrupt the cycle of malaria ... agenda. Such vaccines would ensure that parasite reintroduction is ... bed net." , This approach to developing malaria ...
Breaking Biology News(10 mins):PNAS: From HIV to cancer, IL-37 regulates immune system 2Preterm, low birth-weight babies may need new hips in adulthood 2New malaria vaccines to prevent infection and block transmission get a shot in the arm 2New malaria vaccines to prevent infection and block transmission get a shot in the arm 3New malaria vaccines to prevent infection and block transmission get a shot in the arm 4
(Date:11/21/2014)... 20, 2014 BlueInGreen, LLC ( ... LLC (Pinnacle), and PCI, Inc., leading suppliers of ... have been selected to provide a new state-of-the-art ... Paul R. Noland Wastewater Treatment. The new ... HyDOZ® gas dissolution technology, Pinnacle Ozone’s industry ...
(Date:11/21/2014)... Nov. 20, 2014 /CNW/ - Aequus Pharmaceuticals Inc. ... that it has closed a brokered private placement ... approximately C$3.7 million.  Cormark Securities Inc. and Clarus ... Brokered Offering for a syndicate of agents that ... Corp. (collectively the "Agents"). Concurrently with the Brokered ...
(Date:11/18/2014)... (PRWEB) November 17, 2014 ... open architecture blade-based and rackmount computing infrastructure, today ... K80 dual-GPU accelerator throughout its GPU-enabled blade server ... of the company’s latest proprietary 80-lane Gen3 PCIe ... discrete NVIDIA Tesla K80 dual-GPU accelerator cards in ...
(Date:11/18/2014)... FL (PRWEB) November 18, 2014 Brothers ... announced the launch of PAWSitively Curing Cancer, Inc ... This new 501(c) (3) non-profit organization is dedicated to ... donated goes directly to the University of Florida ... partner with PAWSitively Curing Cancer as the recipient of ...
Breaking Biology Technology:City of Fayetteville Leads Nation with Innovative Ozone Technology 2City of Fayetteville Leads Nation with Innovative Ozone Technology 3City of Fayetteville Leads Nation with Innovative Ozone Technology 4Aequus Pharmaceuticals closes $4.2 million private placement financing 2Aequus Pharmaceuticals closes $4.2 million private placement financing 3Cirrascale® Expands Multi-GPU Peering Solutions with Support for New NVIDIA Tesla K80 Dual-GPU Accelerators 2Cirrascale® Expands Multi-GPU Peering Solutions with Support for New NVIDIA Tesla K80 Dual-GPU Accelerators 3PAWSitively Curing Cancer, Inc. Launched By Two Children for National Pet Cancer Awareness Month 2PAWSitively Curing Cancer, Inc. Launched By Two Children for National Pet Cancer Awareness Month 3
Cached News: