HOME >> BIOLOGY >> NEWS
Spun from bone

RICHLAND, Wash. Bone and enamel start with the same calcium-phosphate crystal building material but end up quite different in structure and physical properties.

The difference in bone and enamel microstructure is attributed to a key protein in enamel that molds crystals into strands thousands of times longer and much stronger than those in bone. The dimension of an enamel strand is 100,000 by 50 by 25 nanometers; bone is 35 by 25 by 4 nanometers.

But how that protein achieves this feat of crystal-strand shape-shifting has remained elusive. Today, scientists have reported the first direct observation of how this protein, amelogenin, interacts with crystals like those in bone to form the hard, protective enamel of teeth.

The study, published by a team from the Department of Energys Pacific Northwest National Laboratory and the University of Southern California on Friday (Sept. 24) in Journal of Biological Chemistry, identifies the region of the protein that interacts with the enamel crystals. The results explain how 100 nanometer spheres of amelogenin cluster like bowling balls around developing enamel crystals, forcing the crystals to elongate into thin, weaved strands that endow enamel with the strength of steel.

The discovery is a milestone for those who would wish to nano-engineer tissues, implants and synthetic coatings based on natures rules.

The proteins determine the crystal structure, said Wendy J. Shaw, lead author and PNNL staff scientist. Like bone, teeth are made of HAP, but the proteins present when teeth form create enamel, a material with entirely different properties from bone. If you can control the interactions between proteins and crystals, the same principal can be applied to nano-patterning and nano-building.

Shaws co-authors are PNNL chief scientist Allison A. Campbell and Michael L. Paine and Malcolm L. Snead of USCs Center for Craniofacial Molecular Biology in Los Angeles.

Earlier stud
'"/>

Contact: Bill Cannon
cannon@pnl.gov
509-375-3732
DOE/Pacific Northwest National Laboratory
24-Sep-2004


Page: 1 2

Related biology news :

1. Rutgers anthropologist, Fossey Fund official, announces plan to save Rwandas mountain gorillas
2. UMass anthropologist investigates dental development and body size in primates
3. Gladstone investigator Mike McCune wins prestigious NIH Directors Pioneer Award
4. UT Southwestern biochemist honored with NIH Directors Pioneer Award
5. Award winning researchers reveal potential new role for Glivec
6. Secretary of Energy announces seven E.O. Lawrence Award Winners
7. Martin Saunders to receive the James Flack Norris Award
8. Berkeley Lab soil scientist Margaret Torn receives Presidential Early Career Award
9. NJIT professor receives Presidential Award for breakthrough research with adult stem cells
10. Second call for proposals for the European Young Investigator Award
11. Virginia Tech professor honored with DeLaval Award

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/15/2016)... 2016 "Increase in mobile transactions is driving ... biometrics market is expected to grow from USD 4.03 ... at a CAGR of 29.3% between 2016 and 2022. ... growing demand for smart devices, government initiatives, and increasing ... component is expected to grow at a high rate ...
(Date:12/8/2016)... , Dec. 8, 2016  Singulex, Inc., the leader ... technology, entered into a license and supply agreement with ... The agreement provides Singulex access to Thermo Scientific BRAHMS ... is used to diagnose systemic bacterial infection ... to aid in assessing the risk of ...
(Date:12/7/2016)... 2016   Avanade is helping Williams Martini ... in history, exploit biometric data in order to critically ... the competitive edge against their rivals after their impressive, ... Avanade has worked with Williams during the 2016 season ... (heart rate, breathing rate, temperature and peak acceleration) for ...
Breaking Biology News(10 mins):
(Date:1/17/2017)... Point, IA (PRWEB) , ... January 17, 2017 ... ... from China for Balance™ GT soybeans. The new Balance™ GT Soybean Performance System ... to glyphosate and isoxaflutole, the active ingredient in the new Balance® Bean herbicide. ...
(Date:1/17/2017)... -- Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH) today ... earnings conference call will be broadcast live over the ... Eastern Time.  A news release detailing the quarterly and ... Eastern Time the morning of the conference call. ... Zimmer Biomet,s Investor Relations website at http://investor.zimmerbiomet.com . ...
(Date:1/17/2017)... , Jan. 17, 2017  Only nine percent ... patients over profits, while only 16 percent believe health ... released today. Meanwhile, 36 percent of U.S. adults believe ... patients over profits, compared to hospitals (23%). ... maelstrom," said Wendy Salomon , vice president of ...
(Date:1/17/2017)... Boston, MA (PRWEB) , ... January 17, 2017 ... ... of the completely re-engineered Drug Safety Technology Consortium™ (SafeTEC™), $3 million in investment ... be validating these new tools and assays, and their applicability in drug safety ...
Breaking Biology Technology:
Cached News: