HOME >> BIOLOGY >> NEWS
Spun from bone

RICHLAND, Wash. Bone and enamel start with the same calcium-phosphate crystal building material but end up quite different in structure and physical properties.

The difference in bone and enamel microstructure is attributed to a key protein in enamel that molds crystals into strands thousands of times longer and much stronger than those in bone. The dimension of an enamel strand is 100,000 by 50 by 25 nanometers; bone is 35 by 25 by 4 nanometers.

But how that protein achieves this feat of crystal-strand shape-shifting has remained elusive. Today, scientists have reported the first direct observation of how this protein, amelogenin, interacts with crystals like those in bone to form the hard, protective enamel of teeth.

The study, published by a team from the Department of Energys Pacific Northwest National Laboratory and the University of Southern California on Friday (Sept. 24) in Journal of Biological Chemistry, identifies the region of the protein that interacts with the enamel crystals. The results explain how 100 nanometer spheres of amelogenin cluster like bowling balls around developing enamel crystals, forcing the crystals to elongate into thin, weaved strands that endow enamel with the strength of steel.

The discovery is a milestone for those who would wish to nano-engineer tissues, implants and synthetic coatings based on natures rules.

The proteins determine the crystal structure, said Wendy J. Shaw, lead author and PNNL staff scientist. Like bone, teeth are made of HAP, but the proteins present when teeth form create enamel, a material with entirely different properties from bone. If you can control the interactions between proteins and crystals, the same principal can be applied to nano-patterning and nano-building.

Shaws co-authors are PNNL chief scientist Allison A. Campbell and Michael L. Paine and Malcolm L. Snead of USCs Center for Craniofacial Molecular Biology in Los Angeles.

Earlier stud
'"/>

Contact: Bill Cannon
cannon@pnl.gov
509-375-3732
DOE/Pacific Northwest National Laboratory
24-Sep-2004


Page: 1 2

Related biology news :

1. Rutgers anthropologist, Fossey Fund official, announces plan to save Rwandas mountain gorillas
2. UMass anthropologist investigates dental development and body size in primates
3. Gladstone investigator Mike McCune wins prestigious NIH Directors Pioneer Award
4. UT Southwestern biochemist honored with NIH Directors Pioneer Award
5. Award winning researchers reveal potential new role for Glivec
6. Secretary of Energy announces seven E.O. Lawrence Award Winners
7. Martin Saunders to receive the James Flack Norris Award
8. Berkeley Lab soil scientist Margaret Torn receives Presidential Early Career Award
9. NJIT professor receives Presidential Award for breakthrough research with adult stem cells
10. Second call for proposals for the European Young Investigator Award
11. Virginia Tech professor honored with DeLaval Award

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Spun from bone

(Date:11/7/2014)... conjunction with the Glendale and ... the Verdugos has announced the " GLENDALE - ... to keep the Verdugo Regional Crime Lab operational after its ... existence, the Lab has processed more than 400 DNA samples, ... "Because our number one priority is the wellbeing of ...
(Date:11/6/2014)... 2014 - Insilico Medicine, Inc, a Baltimore-based bioinformatics ... related diseases announced a research collaboration with the ... Oncology, Inc (OTC: CSBR). , "There are many ... but Champions Oncology,s TumorGraft technology is unique in ... regimen experimentally generating vast amounts of valuable data. ...
(Date:11/4/2014)... death at the right time might actually help boost ... could help in understanding animal populations, pest control and ... in the journal Trends in Ecology and Evolution ... that the kind of positive population effect an overall ... depends on the size and developmental stage of the ...
Breaking Biology News(10 mins):Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2When less is more: Death in moderation boosts population density in nature 2
(Date:11/26/2014)... MADRID , Nov. 26, 2014 ... presented results from a survey of European physicians ... Meeting on Innovation and Biological Therapies" at the ... The event, hosted by EuropaBio and the Spanish ... Ministry of Health, physicians from Spanish oncology and ...
(Date:11/26/2014)... Whitehouse Laboratories is pleased to announce ... (New Jersey) Chamber of Commerce as a member. ... in the North Jersey area, offers Whitehouse Laboratories ... clients in the pharmaceutical and biotechnology areas that ... enables Whitehouse Laboratories a higher level of visibility ...
(Date:11/26/2014)... 2014 The Pittcon marketing department is ... and exposition mobile app, Pittcon 2015 ... the App Store for iOS and Android devices and ... before, during and after the event. It acts as ... companies, technical sessions, Conferee Networking sessions and short courses. ...
(Date:11/26/2014)... (PRWEB) November 26, 2014 CUREā„¢ ... recognition reception on December 5, 2014, in San Francisco ... The MPN Heroes event will honor clinicians, caregivers, and ... of myeloproliferative neoplasms (MPNs). , Special guest speaker ... his family's cancer journey at the reception. Over ...
Breaking Biology Technology:ASBM Presents European Physicians Survey at Spanish Ministry of Health 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 3Pittcon Releases 2015 Mobile App 2CURE Magazine and Incyte to Honor MPN Heroes 2CURE Magazine and Incyte to Honor MPN Heroes 3CURE Magazine and Incyte to Honor MPN Heroes 4
Cached News: