Spurred by the worldwide fight against malaria, scientists release parasite genom...( cture of these genes and function of th...)

Spurred by the worldwide fight against malaria, scientists release parasite genome database

cture of these genes and function of the proteins they encode, to look for patterns of nucleotides or amino acids and to search for gene functions analogous to those found in other organisms. The database will be updated constantly as Plasmodium sequencing progresses.

By utilizing a database architecture that is not tied to peculiarities of the malaria parasite itself, this project also points the way to development of similar databases for other organisms, permitting direct comparison of one organism's genome with another.

Four species cause malaria in humans, but Plasmodium falciparum accounts for more than 90 percent of fatalities. The PlasmoDB database also includes available data on other species of Plasmodium parasites.

The Plasmodium database project is a multifaceted effort, building on pioneering work in genome database development carried out by the Computational Biology and Informatics Laboratory at Penn under the direction of Christian J. Stoeckert and the late G. Christian Overton. Other key members of this team include Brian Brunk, Jonathan Crabtree and Jonathan Schug.

New data-mining tools for the Plasmodium project were developed by Martin Fraunholz and Jessica Kissinger, and the stand-alone CD version is the brainchild of Jules Milgram, all of whom are in Penn's Department of Biology.

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Contact: Steve Bradt
bradt@pobox.upenn.edu
215-573-6604
University of Pennsylvania
5-Apr-2001

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