HOME >> BIOLOGY >> NEWS
St. Jude shows how disorderliness in some proteins lets them interact with a diversity of molecules

Investigators at St. Jude Children's Research Hospital have demonstrated for the first time that--contrary to the long-held belief among scientists that proteins must maintain a rigid structure in order to perform an assigned task--many proteins actually exploit disorderliness in their structure to perform a variety of different jobs. The findings of this research appear in the current, online issue of Nature Structural and Molecular Biology.

The St. Jude finding explains how many of the body's proteins can adapt their structures to the needs of the moment, binding to different molecules depending on the job at hand.

"The potential importance of disorder in the function of some proteins has been discussed by researchers for several years," said Richard W. Kriwacki, PhD, associate member of the St. Jude Department of Structural Biology and senior author of the report. "But until now no one had actually demonstrated how such flexibility allows a protein to interact with different molecules. We've taken a big step in understanding the subtle details of a critical biochemical process in the life of the cell."

Previously, other researchers suggested that 30 to 40 percent of the body's proteins do not rely on a rigid structure to interact with target molecules. In the current study, the St. Jude team verified that idea by showing how a protein called p27 uses two flexible arms to help it bind to a protein complex called Cdk2-cyclin A. This interaction is important because Cdk2-cyclin A is one of the so-called "master timekeepers" of cell division. These timekeepers trigger sequential events leading to the production of new daughter cells. By binding to Cdk2-cyclin A and blocking its activity, p27 disrupts this sequence and prevents the cell from dividing. The importance of p27's role in regulating cell division is highlighted by findings showing that loss of p27 function is a key contributing factor in several types of cancer.

The researchers demonst
'"/>

Contact: Bonnie Cameron
bonnie.cameron@stjude.org
901-495-4815
St. Jude Children's Research Hospital
19-Mar-2004


Page: 1 2

Related biology news :

1. New study shows hope for treating inhalant abuse
2. Chemical derived from vitamin-E shows early promise as cancer drug
3. Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
4. Trial shows which brain cancer patients benefit from temozolomide
5. New research shows plants can shuffle and paste gene pieces to generate genetic diversity
6. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
7. Simian virus 40 not associated with non-Hodgkin lymphoma, study shows
8. A probable cause for high blood pressure identified - shows links with diabetes
9. Blue marlin in gulf have high mercury levels, A&M study shows
10. New research shows air pollution can reduce childrens lung function
11. Pneumococcal vaccine reduces ear infections, pneumonia, new study shows

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/12/2018)... ... September 10, 2018 , ... IONpathTM, a venture-backed ... new Multiplexed Ion Beam Imaging (MIBITM) technology was accepted by the journal Cell ... be shared during a webinar presented by Dr. Mike Angelo on October 2nd, ...
(Date:9/7/2018)... (PRWEB) , ... September 05, 2018 , ... ... Platform for a mAb manufacturing facility late last year, IPS-Integrated Project Services, LLC ... the manufacturing of autologous cell therapies. The iCON solution provides a pre-fabricated modular ...
(Date:8/31/2018)... Ariz. (PRWEB) , ... August 30, 2018 , ... ... is now offering a complimentary cryogenic freezer program for new clients. The freezers ... , The regenerative biologics from R3 Stem Cell consist of amniotic and umbilical ...
Breaking Biology News(10 mins):
(Date:8/23/2018)... ... 22, 2018 , ... Crucial Data Solutions, Inc. announces the ... first fully-featured app for electronic data capture (EDC) and electronic participant reported outcomes ... percent of the market share for mobile devices worldwide; in turn, this enables ...
(Date:8/17/2018)... TITUSVILLE, Fla. (PRWEB) , ... August 16, 2018 , ... ... began when Astro Pak acquired Chemko Technical Services in 2016. Chemko had a well ... by supporting on-site work at KSC on projects such as the ongoing work at ...
(Date:8/14/2018)... , ... August 13, 2018 , ... ... chemical fume hoods and biological safety cabinets. In addition, Labconco produces other lab ... one measure of its commitment to quality and consistency in design and manufacturing. ...
(Date:8/9/2018)... ... August 08, 2018 , ... RMC ... combining its deep pharmaceutical compliance and technical expertise with professional video production ... GxP training requirements. , Bringing training to life for your team ...
Breaking Biology Technology:
Cached News: