HOME >> BIOLOGY >> NEWS
Stanford explores new avenue for brain injury, paralysis research

ften die before regaining contact with other nerves. Most scientists blame this inability to regenerate on a group of nursemaid cells called glia, stationed around neurons. But Golderg's work suggests that while glia cells slow axon growth, they're not the only problem. Goldberg said that while neurons are developing, they get an outside signal they never forget. The message is: stop growing your axon so rapidly and start working on your dendrites.

To show that glial cells weren't solely responsible for the axon's slow regeneration, Goldberg removed the glia from axons in the optic nerves of embryonic and 8-day-old rats. (The optic nerve, which connects the brain to the eyeball, is an extension of the brain and is as injury-intolerant as the rest of the central nervous system.) Even without the glia, the embryonic neurons still regenerated 10 times faster than the neurons that developed in the 8-day-old rats.

From these results, Goldberg speculated that neurons had an internal clock that determined when they were destined to stop regenerating. To test his theory, Goldberg kept groups of isolated embryonic neurons alive in his laboratory until they were the same age as neurons in the 8-day-old rats. These lab-grown neurons were still able to regenerate axons quickly, while those taken from the recently born rats showed much slower axon growth.

These results told Goldberg that age was not the key to an axon's inability to regenerate. Rather, a signal that the neuron encountered in the developing rat must confer the "stop regenerating" message. Now, he had to find the culprit. "I asked if it was hormonal changes that happen at birth and found that it wasn't. So then I asked what kinds of cell types interact with the neurons," Goldberg said. At first he assumed the slow-down signal came from the site to which the axon grows. Upon researching that idea, he discovered instead that the signal was coming from the retina's intera
'"/>

Contact: Amy Adams
amyadams@stanford.edu
650-723-3900
Stanford University Medical Center
6-Jun-2002


Page: 1 2 3

Related biology news :

1. Tiny molecules have big potential as cancer drugs, Stanford researcher believes
2. Stanford researchers findings may shed light on common, deadly birth defect
3. Leukemia stem cells identified by Stanford researchers
4. New view of leukemia cells identifies best treatment options, Stanford researchers say
5. Confidentiality of genetic databases questioned by Stanford researchers
6. Stanford researchers go from heaven to Earth in lifeguard test
7. Transplant rejection averted by simple light exposure in Stanford animal study
8. Fat cells heal skull defects in mice, Stanford research shows
9. Gene-based screen sorts cancer cases, say Stanford researchers
10. Elusive but ubiquitous microbe fingered as gum disease culprit in Stanford study
11. Sticklebacks reveal secrets to evolutionary change in Stanford study

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Stanford explores new avenue for brain injury paralysis research

(Date:7/25/2014)... a molecular testing panel developed at UPMC greatly ... surgery for patients with thyroid nodules and cancer, ... Institute (UPCI), partner with UPMC CancerCenter., The test, ... other diagnostic testing agencies, improved the chances of ... percent, according to the study published this month ...
(Date:7/24/2014)... July 24, 2014 -- Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the ... randomized, active control Phase 3 study of Zerenex (ferric ... for the treatment of hyperphosphatemia in patients with end-stage ... binding and iRon delivery with FErric CiTrate in EsrD) ... the American Society of Nephrology ( JASN ). ...
(Date:7/24/2014)... on different species of fish, according to a ... Exeter which tested fish anti-predator behaviour. , ... predator model when exposed to additional noise, whereas ... , Lead author Dr Irene Voellmy of Bristol,s ... many aquatic environments have increased substantially during the ...
Breaking Biology News(10 mins):Test increases odds of correct surgery for thyroid cancer patients 2Test increases odds of correct surgery for thyroid cancer patients 3Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 4
(Date:7/24/2014)... most natural and synthetic processes prefer to settle ... or energyit is within the realm of non-equilibrium ... constant changes in energy and phases, such as ... conditions allow humans to regulate their body temperature, ... with seismic activity. , But even though ...
(Date:7/24/2014)... July 24, 2014 Your cell ... in modeling lithium-ion battery storage capacity. , New ... a theoretical model created at Lawrence Livermore ... that predicts how carbon components will perform as ... emphasizes the urgent need for higher-performance batteries. Several ...
(Date:7/24/2014)... July 24, 2014 Three companies from ... in Livestrong’s Big C Competition. Out of 700 competition ... headed to the semi-final round. In this round twenty ... accelerator program, complete with mentoring from thought-leaders and medical ... part of the angelMD commitment to the Livestrong vision ...
(Date:7/24/2014)... N.J. , July 24, 2014 ... provider of regulatory and ethical review services for ... Alliance Biosciences. Formerly a division of ... was the leading biosafety and biosecurity consulting firm ... With this addition, WCG,s biosafety division – WCG ...
Breaking Biology Technology:New approach to form non-equilibrium structures 2Getting More Life out of Lithium-ion Batteries 23 angelMD Startups Make Livestrong Big C Semi-finals 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 3
Cached News: