HOME >> BIOLOGY >> NEWS
Stanford explores new avenue for brain injury, paralysis research

ften die before regaining contact with other nerves. Most scientists blame this inability to regenerate on a group of nursemaid cells called glia, stationed around neurons. But Golderg's work suggests that while glia cells slow axon growth, they're not the only problem. Goldberg said that while neurons are developing, they get an outside signal they never forget. The message is: stop growing your axon so rapidly and start working on your dendrites.

To show that glial cells weren't solely responsible for the axon's slow regeneration, Goldberg removed the glia from axons in the optic nerves of embryonic and 8-day-old rats. (The optic nerve, which connects the brain to the eyeball, is an extension of the brain and is as injury-intolerant as the rest of the central nervous system.) Even without the glia, the embryonic neurons still regenerated 10 times faster than the neurons that developed in the 8-day-old rats.

From these results, Goldberg speculated that neurons had an internal clock that determined when they were destined to stop regenerating. To test his theory, Goldberg kept groups of isolated embryonic neurons alive in his laboratory until they were the same age as neurons in the 8-day-old rats. These lab-grown neurons were still able to regenerate axons quickly, while those taken from the recently born rats showed much slower axon growth.

These results told Goldberg that age was not the key to an axon's inability to regenerate. Rather, a signal that the neuron encountered in the developing rat must confer the "stop regenerating" message. Now, he had to find the culprit. "I asked if it was hormonal changes that happen at birth and found that it wasn't. So then I asked what kinds of cell types interact with the neurons," Goldberg said. At first he assumed the slow-down signal came from the site to which the axon grows. Upon researching that idea, he discovered instead that the signal was coming from the retina's intera
'"/>

Contact: Amy Adams
amyadams@stanford.edu
650-723-3900
Stanford University Medical Center
6-Jun-2002


Page: 1 2 3

Related biology news :

1. Tiny molecules have big potential as cancer drugs, Stanford researcher believes
2. Stanford researchers findings may shed light on common, deadly birth defect
3. Leukemia stem cells identified by Stanford researchers
4. New view of leukemia cells identifies best treatment options, Stanford researchers say
5. Confidentiality of genetic databases questioned by Stanford researchers
6. Stanford researchers go from heaven to Earth in lifeguard test
7. Transplant rejection averted by simple light exposure in Stanford animal study
8. Fat cells heal skull defects in mice, Stanford research shows
9. Gene-based screen sorts cancer cases, say Stanford researchers
10. Elusive but ubiquitous microbe fingered as gum disease culprit in Stanford study
11. Sticklebacks reveal secrets to evolutionary change in Stanford study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/30/2017)... Today, American Trucking Associations announced Seeing ... and eye tracking software, became the newest member ... "Artificial intelligence and advanced sensing algorithms ... driver,s attentiveness levels while on the road.  Drivers ... fatigue and prevent potential accidents, which could lead ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. ... company, announces the filing of its 2016 Annual Report on Form ... Exchange Commission. ... Form 10-K is available in the Investor Relations section of the ... on the SEC,s website at http://www.sec.gov . 2016 ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... genomics analysis platform specifically designed for life science researchers to analyze and ... researcher Rosalind Franklin, who made a major contribution to the discovery of ...
(Date:10/11/2017)... BALTIMORE, Md. (PRWEB) , ... October 11, 2017 ... ... for digital pathology, announced today it will be hosting a Webinar titled, “Pathology ... of  Advanced Pathology Associates , on digital pathology adoption best practices and how ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology ... drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription ... is able to cross the cell membrane and bind intracellular STAT3 and inhibit ...
(Date:10/10/2017)... research firm Parks Associates announced today that Tom Kerber ... Annual Meeting , October 11 in Scottsdale, Arizona . ... how smart safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and the ...
Breaking Biology Technology:
Cached News: