HOME >> BIOLOGY >> NEWS
Stanford researchers create diabetic fruit flies in lab

nearly identical in flies and humans, including the genes and molecular defenses used by the two systems. Because of this similarity, researchers have been able to learn more about the human immune system by studying flies.

Rulifson said the same could be true for insulin-producing cells. "If the fly cells are using the same molecules and genes as humans, then there's a good chance that much of the pathway of development is conserved," he said.

To make the diabetic flies, Rulifson first identified a group of cells in the brain that produce insulin. He then specifically destroyed only those insulin-producing cells in the fly larvae. These larvae were significantly smaller than their normal counterparts and took longer to develop into full-fledged flies. What's more, the fly larvae that lacked insulin had high blood-sugar levels, comparable to human diabetes.

When Rulifson looked at where the insulin-producing cells were located in the fly brain, he found that they sent projections to the heart, where the nerves released insulin into the larvae's circulatory system. This is similar to how the pancreatic cells release insulin into the human bloodstream.

The nerves also sent projections to a group of cells that release a protein similar to human glucagon. This substance has the opposite effect of insulin - causing cells to release stored sugar into the blood when blood-sugar levels are low. Together, the two opposing hormones keep human blood-sugar levels steady, and may do the same in flies.

Rulifson called these similarities between fly and human hormonal systems "the tip of the iceberg." He said there is enough similarity to suspect his diabetic flies will be good models for the human disease. "This fly model could help us understand the origin of insulin-producing cells in people," he said.


'"/>

Contact: Amy Adams
amyadams@stanford.edu
650-723-3900
Stanford University Medical Center
9-May-2002


Page: 1 2

Related biology news :

1. Tiny molecules have big potential as cancer drugs, Stanford researcher believes
2. Stanford researchers findings may shed light on common, deadly birth defect
3. Leukemia stem cells identified by Stanford researchers
4. New view of leukemia cells identifies best treatment options, Stanford researchers say
5. Confidentiality of genetic databases questioned by Stanford researchers
6. Stanford researchers go from heaven to Earth in lifeguard test
7. Transplant rejection averted by simple light exposure in Stanford animal study
8. Fat cells heal skull defects in mice, Stanford research shows
9. Gene-based screen sorts cancer cases, say Stanford researchers
10. Elusive but ubiquitous microbe fingered as gum disease culprit in Stanford study
11. Sticklebacks reveal secrets to evolutionary change in Stanford study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)...  IBM (NYSE: IBM ) is introducing several innovative ... to developing collaboration between startups and global businesses, taking place ... the event, nine startups will showcase the solutions they have ... France is one ... a 30 percent increase in the number of startups created ...
(Date:4/24/2017)... 24, 2017 Janice Kephart , ... Identity Strategy Partners, LLP (IdSP) , today issues ... President Trump,s March 6, 2017 Executive Order: ... vetting can be instilled with greater confidence, enabling ... all refugee applications are suspended by until at ...
(Date:4/13/2017)... India , April 13, 2017 According to ... Proofing, Identity Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, ... MarketsandMarkets™, the IAM Market is expected to grow from USD 14.30 Billion ... Growth Rate (CAGR) of 17.3%. ... MarketsandMarkets ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... -- VMS BioMarketing, a leading provider of patient support solutions, has ... (CNE) network, which will launch this week. The VMS CNEs ... professionals to enhance the patient care experience by delivering peer-to-peer ... care professionals to help women who have been diagnosed and ... ...
(Date:10/11/2017)... ... 11, 2017 , ... Singh Biotechnology today announced that the ... its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) B VHH13 single ... the cell membrane and bind intracellular STAT3 and inhibit its function. Dysregulation of ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... Dr. Bob ... at his local San Diego Rotary Club. The event entitled “Stem ... CA and had 300+ attendees. Dr. Harman, DVM, MPVM was joined by two ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program Committee is ... honoring scientists who have made outstanding contributions to analytical chemistry and applied spectroscopy. ... world’s leading conference and exposition for laboratory science, which will be held February ...
Breaking Biology Technology:
Cached News: