HOME >> BIOLOGY >> NEWS
Stanford researchers create diabetic fruit flies in lab

nearly identical in flies and humans, including the genes and molecular defenses used by the two systems. Because of this similarity, researchers have been able to learn more about the human immune system by studying flies.

Rulifson said the same could be true for insulin-producing cells. "If the fly cells are using the same molecules and genes as humans, then there's a good chance that much of the pathway of development is conserved," he said.

To make the diabetic flies, Rulifson first identified a group of cells in the brain that produce insulin. He then specifically destroyed only those insulin-producing cells in the fly larvae. These larvae were significantly smaller than their normal counterparts and took longer to develop into full-fledged flies. What's more, the fly larvae that lacked insulin had high blood-sugar levels, comparable to human diabetes.

When Rulifson looked at where the insulin-producing cells were located in the fly brain, he found that they sent projections to the heart, where the nerves released insulin into the larvae's circulatory system. This is similar to how the pancreatic cells release insulin into the human bloodstream.

The nerves also sent projections to a group of cells that release a protein similar to human glucagon. This substance has the opposite effect of insulin - causing cells to release stored sugar into the blood when blood-sugar levels are low. Together, the two opposing hormones keep human blood-sugar levels steady, and may do the same in flies.

Rulifson called these similarities between fly and human hormonal systems "the tip of the iceberg." He said there is enough similarity to suspect his diabetic flies will be good models for the human disease. "This fly model could help us understand the origin of insulin-producing cells in people," he said.


'"/>

Contact: Amy Adams
amyadams@stanford.edu
650-723-3900
Stanford University Medical Center
9-May-2002


Page: 1 2

Related biology news :

1. Tiny molecules have big potential as cancer drugs, Stanford researcher believes
2. Stanford researchers findings may shed light on common, deadly birth defect
3. Leukemia stem cells identified by Stanford researchers
4. New view of leukemia cells identifies best treatment options, Stanford researchers say
5. Confidentiality of genetic databases questioned by Stanford researchers
6. Stanford researchers go from heaven to Earth in lifeguard test
7. Transplant rejection averted by simple light exposure in Stanford animal study
8. Fat cells heal skull defects in mice, Stanford research shows
9. Gene-based screen sorts cancer cases, say Stanford researchers
10. Elusive but ubiquitous microbe fingered as gum disease culprit in Stanford study
11. Sticklebacks reveal secrets to evolutionary change in Stanford study

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Stanford researchers create diabetic fruit flies lab

(Date:5/19/2015)... Sweden , May 18, 2015 ... fingerprint sensors FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from one ... from June until and including Q3 2015 and the sensors ... . Communicated order values for 2015 hereby amount to ... for Q1 2015 of 140 MSEK and a number of ...
(Date:5/14/2015)... , May 14, 2015  Verificient Technologies, ... verification and online remote proctoring, announced a ... (SaaS) company and creator of the Canvas ... the two companies will benefit from the ... As a fully integrated multifactor ...
(Date:5/8/2015)... , May 8, 2015 Synaptics Inc. (NASDAQ: ... today announced that members of the executive management team will ... 43rd Annual Technology, Media and Telecom Conference Date: May ... in Boston, MA Cowen ... 2015 Time: 2:45pm ET Location: The New York Palace Hotel, ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Synaptics to Present at Upcoming Investor Conferences 2
(Date:5/25/2015)... BOSTON , May 26, 2015  PureTech, a ... toughest health challenges in disruptive ways, announced today that ... Foundation and former CEO of Pearson, has been appointed ... Senior Independent Director and that current Board member ... appointed Board Chairman. Dr. Ben Shapiro , PureTech,s ...
(Date:5/22/2015)... DUBLIN , May 22, 2015  Actavis plc ... of the U.S. Court of Appeals for the Second ... 2014 preliminary injunction requiring the Company to continue distribution ... Logo - http://photos.prnewswire.com/prnh/20130124/NY47381LOGO   ... uphold this ruling, we intend to continue our strong ...
(Date:5/22/2015)... Baylor Research Institute (BRI) at Dallas ... in Phoenix, AZ , today announce ... treatments for patients with a broad range of cancers. Aligning ... clinical trials and access to technology to drive the development ... bedside across Baylor Scott & White Health,s 49 ...
(Date:5/21/2015)... 2015  Susan Hedstrom, Executive Director of the ... dedicated to supporting research to advance the understanding ... that FPWR has received the organization,s largest donation ... contributed $1 million in support of the organization,s ... "Our gift signifies our tremendous ...
Breaking Biology Technology:PureTech Adds Dame Marjorie Scardino to Board of Directors, Names Joi Ito as Chairman of the Board and Expands Management Team 2PureTech Adds Dame Marjorie Scardino to Board of Directors, Names Joi Ito as Chairman of the Board and Expands Management Team 3Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 2Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 3Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 4Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 5Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 6Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 7Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 8Precision Medicine Collaboration to Increase Options for Cancer Patients 2Precision Medicine Collaboration to Increase Options for Cancer Patients 3Precision Medicine Collaboration to Increase Options for Cancer Patients 4The Foundation for Prader-Willi Research Receives $1M Contribution in Support of Clinical Initiatives 2
Cached News: