HOME >> BIOLOGY >> NEWS
Stanford researcher's findings may shed light on common, deadly birth defect

STANFORD, Calif. - Top poker players know that the face mirrors the brain. Specialists in embryonic development wouldn't disagree. In fact, because the same clumps of primordial cells mold the final features of both, a close look at a child's face can often yield clues about less visible problems within the skull: a cleft lip or other abnormal facial features can read like a map of brain development gone awry.

Now for the first time, researchers at the Stanford University School of Medicine and the University of California-San Francisco have provided a powerful example of how one genetic pathway can wend its way through an emerging "city" of brain structures and facial features, influencing each phase of development in slightly different ways. Like an architect overseeing a complicated building process, a key protein required early in development for embryonic survival exerts a waning but vital influence throughout the sequential construction of the brain and face. Blocking this protein's action at varying developmental stages yields very different anatomical results - including one in which only the exterior, or the face, is affected while the scaffolding, or the brain, is left unscathed.

The results not only shed light on a common cause of miscarriage in humans, they also help to untangle a medical mystery: why children born with the same genetic disorder can have vastly different symptoms.

"Everybody recognizes that in some genetic diseases, one person can be much more severely affected than another, and we've all wondered 'Why is that?'" said Jill Helms, DDS, PhD. "We thought that uncovering the gene or genes responsible for the condition might answer the question, but in many cases that has only added more confusion."

Helms, an associate professor in plastic and reconstructive surgery, recently came to Stanford from UCSF, where the current work was conducted. She is the senior author of the research, which appears in
'"/>

Contact: Krista Conger
kristac@stanford.edu
650-725-5371
Stanford University Medical Center
16-Aug-2004


Page: 1 2 3

Related biology news :

1. Tiny molecules have big potential as cancer drugs, Stanford researcher believes
2. Leukemia stem cells identified by Stanford researchers
3. New view of leukemia cells identifies best treatment options, Stanford researchers say
4. Confidentiality of genetic databases questioned by Stanford researchers
5. Stanford researchers go from heaven to Earth in lifeguard test
6. Transplant rejection averted by simple light exposure in Stanford animal study
7. Fat cells heal skull defects in mice, Stanford research shows
8. Gene-based screen sorts cancer cases, say Stanford researchers
9. Elusive but ubiquitous microbe fingered as gum disease culprit in Stanford study
10. Sticklebacks reveal secrets to evolutionary change in Stanford study
11. Genetic screening study at Stanford IDs most aggressive adult leukemia strains

Post Your Comments:
(Date:4/20/2015)... , April 20, 2015 The ... Glenbeigh Records Management (GRM), Ireland,s ... Dubai Islamic Bank. Having built up an impressive track record ... a leading player within the records management sector in ... to double is GCC staffbase and employ a further eight ...
(Date:4/14/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces that its Wocket® smart ... Design Awards under the category  ,Product Design – Technology,. ... are part of a global multi-disciplinary awards program. The ... marketplace, industry and judging panel. Winners will be announced ...
(Date:4/10/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cjk4gb/security ) has ... - NEC" report to their offering. ... to supply a range of IT security management and ... on the development of a Big Data and cloud ... Asia-Pacific region is a core ...
Breaking Biology News(10 mins):Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3NEC Security Competitive Profile 2015 2
(Date:4/24/2015)... 2015 /CNW Telbec/ - Mirego, leader in mobile strategies and ... three mobile app extensions for the all new Apple Watch. ... Familiprix, OMSignal and MediaMiser, these extensions will reinvent the way ... specifically for wrist use.  Available today in ... highly customizable tactile smartwatch that makes for an excellent buddy ...
(Date:4/23/2015)... April 23, 2015 Athena San Diego, ... of executive women in San Diego’s technology and life ... Annual Pinnacle Awards at their Gala on April 30, ... Register now at http://athenasd.org/events/ , The Pinnacle ... Athena San Diego vision of fostering networking, risk taking ...
(Date:4/23/2015)... , April 23, 2015  Neurocrine Biosciences, Inc. (Nasdaq: ... report its first quarter 2015 results before the Nasdaq ... then host a live conference call and webcast to discuss ... morning, April 30, 2015 at 8:00 a.m. Eastern Time ... the live conference call by dialing 866-952-1906 (US) or ...
(Date:4/23/2015)... Prospects for Leading Companies in ... Details   We predict the global healthcare ... in 2015 and will grow at a CAGR of 6.3% ... around the world and increasing functional requirements for healthcare packaging ... global healthcare packaging market. A global ageing population, ...
Breaking Biology Technology:Familiprix, OMSignal and MediaMiser apps available today for Apple Watch 2Athena Pinnacle Awards to Honor Executives, Corporations and Educators Working to Promote Women Leaders 2Neurocrine Biosciences Announces Conference Call and Webcast to Report First Quarter 2015 Results 2Healthcare Packaging Market Forecast 2015-2025 2Healthcare Packaging Market Forecast 2015-2025 3Healthcare Packaging Market Forecast 2015-2025 4Healthcare Packaging Market Forecast 2015-2025 5Healthcare Packaging Market Forecast 2015-2025 6Healthcare Packaging Market Forecast 2015-2025 7Healthcare Packaging Market Forecast 2015-2025 8Healthcare Packaging Market Forecast 2015-2025 9Healthcare Packaging Market Forecast 2015-2025 10
Cached News: