HOME >> BIOLOGY >> NEWS
Stanford researcher's findings may shed light on common, deadly birth defect

STANFORD, Calif. - Top poker players know that the face mirrors the brain. Specialists in embryonic development wouldn't disagree. In fact, because the same clumps of primordial cells mold the final features of both, a close look at a child's face can often yield clues about less visible problems within the skull: a cleft lip or other abnormal facial features can read like a map of brain development gone awry.

Now for the first time, researchers at the Stanford University School of Medicine and the University of California-San Francisco have provided a powerful example of how one genetic pathway can wend its way through an emerging "city" of brain structures and facial features, influencing each phase of development in slightly different ways. Like an architect overseeing a complicated building process, a key protein required early in development for embryonic survival exerts a waning but vital influence throughout the sequential construction of the brain and face. Blocking this protein's action at varying developmental stages yields very different anatomical results - including one in which only the exterior, or the face, is affected while the scaffolding, or the brain, is left unscathed.

The results not only shed light on a common cause of miscarriage in humans, they also help to untangle a medical mystery: why children born with the same genetic disorder can have vastly different symptoms.

"Everybody recognizes that in some genetic diseases, one person can be much more severely affected than another, and we've all wondered 'Why is that?'" said Jill Helms, DDS, PhD. "We thought that uncovering the gene or genes responsible for the condition might answer the question, but in many cases that has only added more confusion."

Helms, an associate professor in plastic and reconstructive surgery, recently came to Stanford from UCSF, where the current work was conducted. She is the senior author of the research, which appears in
'"/>

Contact: Krista Conger
kristac@stanford.edu
650-725-5371
Stanford University Medical Center
16-Aug-2004


Page: 1 2 3

Related biology news :

1. Tiny molecules have big potential as cancer drugs, Stanford researcher believes
2. Leukemia stem cells identified by Stanford researchers
3. New view of leukemia cells identifies best treatment options, Stanford researchers say
4. Confidentiality of genetic databases questioned by Stanford researchers
5. Stanford researchers go from heaven to Earth in lifeguard test
6. Transplant rejection averted by simple light exposure in Stanford animal study
7. Fat cells heal skull defects in mice, Stanford research shows
8. Gene-based screen sorts cancer cases, say Stanford researchers
9. Elusive but ubiquitous microbe fingered as gum disease culprit in Stanford study
10. Sticklebacks reveal secrets to evolutionary change in Stanford study
11. Genetic screening study at Stanford IDs most aggressive adult leukemia strains

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/18/2016)... --> --> Competitive Landscape Analysis ... Physical infrastructure and Perimeter Surveillance & Detection Systems ... and the continuing migration crisis in the Middle ... led visiongain to publish this unique report, which is crucial ... & security companies in the border security market and the ...
(Date:3/14/2016)... March 14, 2016 http://www.apimages.com ... --> - Renvoi : image disponible via ... --> --> DERMALOG, le ... de nouveaux lecteurs d,empreintes digitales pour l,enregistrement des ... sera utilisé pour produire des cartes d,identité aux ...
(Date:3/9/2016)... NEW YORK , March 9, 2016 ... current and future states of the RNA Sequencing (RNA ... in segments such as instruments, tools and reagents, data ... Analyze various segments of the RNA-Sequencing market such ... RNA-Sequencing services Identify the main factors affecting each segment ...
Breaking Biology News(10 mins):
(Date:5/22/2016)... ... May 22, 2016 , ... Doctors in Rome say ... the asbestos cancer, malignant mesothelioma. Surviving Mesothelioma has just posted an article on the ... University of Rome’s Department of Clinical Sciences and Translational Medicine evaluated more than 150 ...
(Date:5/20/2016)... ... May 20, 2016 , ... Korean researchers say Manumycin A triggers apoptosis, ... new way to treat the disease. Surviving Mesothelioma has just posted an article on ... several Korean institutions based their mesothelioma study on the fact the Manumycin A, a ...
(Date:5/19/2016)... , May 19, 2016  AdvancedFlow Systems ... Inc. (AGI), based out of Maple ... Biogas Ltd. to its existing portfolio of contract ... agreement. AFS along with its sister companies Surround ... a vertically integrated industrial group that specializes in ...
(Date:5/19/2016)... SAN DIEGO , May 19, 2016 /PRNewswire/ ... (OTCBB: RGBP), (OTC PINK: RGBP) and (OTC PINK: RGBPP) announced ... at creating the first cord blood based cancer ... a provisional patent application, Regen described a generation ... activity was potentiated by gene silencing.  The product ...
Breaking Biology Technology:
Cached News: