HOME >> BIOLOGY >> NEWS
Stanford's new antigen microarrays open window to better disease screening

STANFORD, Calif. - Your immune system normally protects against disease, but in some cases - such as with rheumatoid arthritis, lupus, and type-I diabetes - the immune system actually attacks your body. Until now, these disorders, called autoimmune diseases, have been difficult to diagnose and treat. But a new microarray-based technology developed at Stanford University Medical Center may help solve the problem.

Antigen microarrays, as reported in the March issue of Nature Medicine, give doctors a glimpse of which molecules (antigens) come under attack in an autoimmune disease. By identifying these antigens, doctors can pinpoint diseases and treatment options.

"Right now clinicians test each antigen separately - and each one can take weeks," said P.J. Utz, MD, assistant professor of immunology and rheumatology and senior author on the study. "These arrays could enable a clinician to diagnose the disease on the first visit."

The antigen microarrays - developed in collaboration with Lawrence Steinman, MD, professor of neurology and neurological sciences - consist of glass slides dotted with thousands of proteins and other molecules that are often attacked in autoimmune diseases. To use the microarray, doctors draw a blood sample from the patient and incubate it on the array. Those antibodies that attack molecules on the array will locate their target and latch on. Fluorescent molecules are then added to detect the antibodies, creating colored spots on the slide. From there, it's a matter of counting the spots to see which antigens the immune system recognized.

In normal people, the antibodies will ignore most antigens on the array. Diabetics, however, may produce arrays with spots corresponding to pancreas cell proteins, and people with rheumatoid arthritis produce spots that correspond to molecules found in the joints.

Utz and William Robinson, MD, PhD, a fellow in the division of immunolo
'"/>

Contact: Amy Adams
amyadams@stanford.edu
650-723-3900
Stanford University Medical Center
6-Mar-2002


Page: 1 2

Related biology news :

1. Researchers go fishing, pull out antigens
2. Hopkins researchers identify transplantation antigens among Sioux Indians
3. Cyclin B1 identified as a new tumor antigen and candidate for the development of a cancer vaccine
4. UC Berkeley group finds first prostate cancer antigen, providing hope for an eventual vaccine against the tumor
5. UroGenesys researchers discover new target antigen for prostate cancers
6. Library on a Slide: Whole genome microarrays for comparative genomics
7. Study by Tufts biologist provides window into progression of some degenerative diseases
8. Film found on windows after 9/11 reveals higher level of pollutants
9. Germ-free transparent fish open new window into gut development
10. Yeast mutations offer window into human disease
11. New findings are a window into the late stages of Lou Gehrigs disease

Post Your Comments:
(Date:11/21/2014)... Nov. 20, 2014   Atmel® Corporation (NASDAQ: ... (MCU) and touch technology solutions, today launched the industry,s ... with the widest V cc range from 1.7V ... and faster I 2 C bus communication speeds, and ... memory making them ideal for consumer, industrial, computer, and ...
(Date:11/18/2014)...   EyeLock Inc. , a market leader ... USA (Safran), a leading U.S. provider of ... partnership to offer comprehensive biometric identity solutions and ... screening and financial services markets. As ... through a nationwide network of 1,100 IdentoGO® Centers.  ...
(Date:11/10/2014)... U.S. store shelves in early 2010, and people have ... packets can be tossed into a washing machine without ... The convenience, though, has come with risks for young ... Children,s Hospital found that from 2012 through 2013, U.S. ... than 6 years of age swallowing, inhaling, or otherwise ...
Breaking Biology News(10 mins):Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3Study finds laundry detergent pods, serious poisoning risk for children 2
(Date:11/26/2014)... MINNEAPOLIS , Nov. 25, 2014 Bio-Techne ... it has appointed Robert Gavin to serve ... of the Protein Platforms Division.  Mr. Gavin will be ... business segment, which includes the ProteinSimple business acquired in ... San Jose, California -based ProteinSimple ...
(Date:11/26/2014)... WARREN, N.J. , Nov. 25, 2014  Roka Bioscience, ... focused on providing advanced testing solutions for the detection of ... will present at the Piper Jaffray  26 th Annual ... conference will be held at The New York Palace in ... During this presentation, material information concerning the Company, its operations, ...
(Date:11/24/2014)... UAE, November 24, 2014 Five ... Bin Rashid Al Maktoum Awards for Medical Sciences", in ... Dubai, United Arab Emirates , on 15 December ... , The Carter Center which won the ... actively involved in numerous programs that aim to improve ...
(Date:11/24/2014)... Belgium , Nov. 24, 2014 ... on developing diagnostic tests for cancer and other conditions, today ... be presented at the Science for Business BioWin Day 2014, ... . The data come from VolitionRx,s lung cancer pilot ... department of the Centre Hospitalier Universitaire (CHU) de Liege in ...
Breaking Biology Technology:Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 2Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 3Roka Bioscience to Present at the Piper Jaffray Healthcare Conference 2Five US Winners Among Recipients of Hamdan Medical Awards 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 4VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 5VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 6
Cached News: