Statins' beneficial effects on HDL

Statins are a widely prescribed family of drugs that lower levels of LDL by blocking synthesis of the cholesterol precursor mevalonate. In addition, these drugs have several other effects that are also potentially antiatherogenic, notably an increase in levels of HDL and its associated apolipoprotein A-I (apoA-I). Martin et al. have investigated the basis of this induction, which they show occurs as a consequence of apoA-I promoter activation in cells depleted of mevalonate. In the course of this work they have uncovered an unsuspected link between the transcription factor PPARa, which activates apoA-I expression, and the transcriptional response to statins. As the authors note, mevalonate is not only required as a precursor to cholesterol and related sterols but is also essential to maintain levels of nonsterol lipids, which have important structural and regulatory functions. In particular, they are required for the lipid modification (geranylgeranylation) of the Rho family of protein kinases. Martin et al. define the outlines of a pathway whereby geranylgeranylated RhoA suppresses PPARa activity. By blocking mevalonate synthesis, statins apparently derepress PPARa and thereby activate apoA-I transcription and the biosynthesis of HDL. This work defines a second branch of the pathway by which statins regulate the profile of lipoproteins in the blood. The first, now-classical branch involves sterol lipids and blocks LDL synthesis. The second involves the nonsterol products of mevalonate and PPARa and induces HDL synthesis. Filling in the details of the second branch may identify novel players that could be targeted specifically to increase reverse transport of cholesterol for therapeutic benefit.


Contact: John Ashkenas
Journal of Clinical Investigation

Page: 1

Related biology news :

1. Manipulating biotope space can enhance beneficial biodiversity effects
2. OneWorld Health CEO outlines mutually beneficial collaborations between industry, nonprofits at BIO
3. Unlocking the genetics and evolution of the dog could prove beneficial for humans
4. Respiratory-pacing device found beneficial in heart failure
5. In mutually beneficial relationship, slowest-evolving species gains upper hand
6. Walnut consumption may reduce heart disease risk by beneficially redistributing cholesterol
7. Making science museums more dynamic, beneficial
8. NHLBI study shows reduced fat intake to lower cholesterol is safe and beneficial for children
9. Two studies add to the growing evidence that green tea is beneficial for health, according to the
10. Genetically engineered organisms: Hazardous or beneficial
11. 9/11 search-and-rescue dogs exhibit few effects from exposure to disaster sites

Post Your Comments:

(Date:10/27/2019)... ... October 26, 2019 , ... Since 2010, The HOTH has served over ... the success of their clients, they’ve earned a place on the highly-competitive and desirable ... won many additional awards and accolades along the way. , Now, The HOTH ...
(Date:10/26/2019)... ... October 24, 2019 , ... World Cord Blood Day (WCBD) takes place ... midwives to learn about the current and future uses of cord blood stem cells, ... being used to treat and cure over 80 different life-threatening diseases, including leukemia, lymphoma, ...
(Date:10/26/2019)... ... October 25, 2019 , ... ... therapy in La Plata, MD. Orofacial myofunctional disorders (OMDs) are abnormal movement patterns ... and speaks. This can include anything from difficulty swallowing and limited tongue movement ...
Breaking Biology News(10 mins):
(Date:10/8/2019)... ... October 07, 2019 , ... Erchonia Corporation, the global ... today announces that the U.S. Food and Drug Administration (FDA) has granted the ... temporary relief of chronic neck and shoulder pain of musculoskeletal origin. , Erchonia ...
(Date:10/3/2019)... ... October 01, 2019 , ... ... and reset itself, announced the midway point of its randomized research trial for ... study is to measure the efficacy of a non-invasive technology which compares tones ...
(Date:10/3/2019)... ... 02, 2019 , ... Today marked the official launch of ... program outsourcing success by cultivating radical improvements in leadership, staff, and broader project ... Reese, phaseUP™ brings clients deep, broad and unique expertise in the intricacies of ...
(Date:10/3/2019)... ... October 02, 2019 , ... eKare’s inSight® digital 3D imaging and wound ... by the East Midlands Academic Health Science Network (EMAHSN), the innovation arm of the ... by providing support to develop and deploy solutions to the most pressing challenges facing ...
Breaking Biology Technology:
Cached News: