HOME >> BIOLOGY >> NEWS
Stem-cell therapy could have benefits and risks for heart-attack PTs

Two studies in this week's issue of THE LANCET raise questions about the feasibility and safety of stem-cell therapy for heart disease, suggesting that such treatments could have both benefits and drawbacks.

Adult haemopoietic stem cells give rise to blood cells, and are thought to be able to generate other types of cell. Recent studies have investigated the potential of stem cells to reverse heart damage caused by diseases such as acute myocardial infarction (heart attack). Use of granulocyte-colony stimulating factor (G-CSF) to mobilise stem cells has shown promise, but its safety has not been tested in patients with myocardial infarction.

Hyun-Jae Kang, Huo-Soo Kim, and colleagues from Seoul National University, Republic of Korea, studied 27 patients with stable myocardial infarction who underwent coronary stenting. After follow-up assessment in 11 patients, the investigators noted improved heart function in the seven who were randomly assigned to receive an infusion of their own peripheral blood stem-cells and G-CSF. However, an unexpectedly high rate of in-stent restenosis (recurrence of coronary artery narrowing) was seen in patients given G-CSF, either alone or in combination with stem-cell infusion, and therefore trial enrolment was stopped.

In a Research letter (p 783), Richard Vulliet from the University of California and colleagues report that after being injected with bone-marrow stem-cells, evidence of myocardial infarction was seen in the hearts of dogs.

In a Commentary (p 746), Hiroaki Matsuba (Kyoto University Hospital, Japan) notes that these potential complications should be investigated thoroughly before such methods are more widely used in patients.

Contact:
Dr. Hyo-Soo Kim, Department of Internal Medicine, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea. T) 82-2-760-2226; F) 82-2-766-8904; E) hyosoo@snu.ac
'"/>


Contact: Joe Santangelo
j.santangelo@elsevier.com
212-633-3810
Lancet
3-Mar-2004


Page: 1 2

Related biology news :

1. Stem-cell research and reproductive cloning laws should be separate
2. Stem-cell defect underlies common genetic disorder
3. Targeted therapy knocks out pediatric brain cancer in mice
4. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
5. Columbia research to examine gene influence on severity of peridontal disease, therapy response
6. Case for IBD combination therapy comes from research at Baylor, MIT and Hebrew University
7. The search for a kinder, gentler chemotherapy
8. Embryonic stem cell therapy shows steady benefits in rebuilding infarcted heart
9. Retroviral gene therapy? ASLV, HIV, and MLV show distinct target site preferences
10. Gene changes linked to increased eye pressure may have implications for glaucoma therapy
11. Jefferson Lab detector technology aids development of cystic fibrosis therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/27/2019)... ... April 26, 2019 , ... ... on Thursday, April 25. More than 30 student venture teams, representing nearly 150 ... more than $75,000. , The top five teams in the College League ...
(Date:4/25/2019)... ... April 24, 2019 , ... NDA Partners Chairman Carl Peck, MD ... of experience in the development of drug and genomic diagnostic products for therapeutic indications ... joining NDA Partners, Dr. Maddala served as Vice President of Biometrics at GRAIL, Inc., ...
(Date:4/18/2019)... , ... April 18, 2019 , ... ... trials have emerged as a popular trial design that have the potential to ... been fully adopted by many sponsors due to the complexity of regulations, potential ...
Breaking Biology News(10 mins):
(Date:4/8/2019)... Utah and BOSTON (PRWEB) , ... April 08, ... ... delivering cloud-based enterprise-class unified communications and collaboration solutions, announced today the launch of ... integration to an unprecedented range of business and contact-orientated applications while using CT ...
(Date:4/8/2019)... Zealand (PRWEB) , ... April 09, 2019 , ... ... infectious disease, the innovative non-profit research center Chan Zuckerberg Biohub (CZ Biohub) has ... study of antibody repertoires is part of CZ Biohub’s efforts to establish new ...
(Date:4/4/2019)... ... April 03, 2019 , ... LeadingBiotech, an exclusive event ... today announces its Boston CEO conference to be held May 28-29, 2019 at ... opportunities with high-level panels and discussions from past, present and future change-makers. ...
(Date:3/27/2019)... ... March 26, 2019 , ... A leader in the field of Regenerative Veterinary ... the United States and Canada since 2004. The primary indications for VetStem Regenerative ... in the dog, cat, and horse. Recently, VetStem teamed up with the world-renowned ...
Breaking Biology Technology:
Cached News: