Stem cells for eggs and sperm also control aging in roundworm

The raw material for each generation -- the pool of stem cells that gives rise to eggs and sperm -- also controls the rate of aging into adulthood, UCSF scientists have found in research on the roundworm C. elegans. The unsuspected role may find parallels in other organisms including humans, they suggest.

The finding shows for the first time that genes act in the adult animal to control its rate of aging. The stem cells, it seems, can modify lifespan even as aging is proceeding.

The key stem cells, the scientists found, are not those that actually become egg or sperm, but their sister cells from the same stem cell pool, known as "proliferating germline stem cells," that divide continuously in the animals reproductive tissues.

"Now we know that these proliferating stem cells are master control cells, sitting at the top of the paths that affect both reproduction and aging," said Cynthia Kenyon, PhD, the Herbert Boyer Professor of Biochemistry and Biophysics at UCSF.

The research, coupled with other findings, indicates that the pool of egg and sperm precursor stem cells affects lifespan by influencing a steroid hormone. If a hormone is found to affect human aging as well, it could make a likely target for drugs to prolong life, the researchers speculate.

The dual stem cell influence over both reproduction and aging suggests that the relationship may have evolved to assure animals reproduce while they are still young, according to the scientists.

Their study is reported in the January 18 issue of the journal Science.

Lead author is Nuno Arantes-Oliveira, a graduate student in Kenyons lab.

In the last few years, Kenyons research group has identified several genes in C. elegans that dramatically affect aging, and has zeroed in on the reproductive system as one source of signals that control the lifespan.

Three years ago the lab reported that signals from the germline the source of sperm and eggs

Contact: Wallace Ravven
University of California - San Francisco

Page: 1 2 3

Related biology news :

1. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
2. Researchers develop fast track way to discover how cells are regulated
3. Chemical signals health of brain cells Symposium
4. New dye directly reveals activated proteins in living cells
5. NJIT professor receives Presidential Award for breakthrough research with adult stem cells
6. Complex cells likely arose from combination of bacterial and extreme-microbe genomes
7. Smac-ing back at cancer cells
8. Bone marrow cells routinely help with wound healing
9. Genuine stem cells found in skin might treat hair loss, wounds
10. Skin stem cells give hairless mice hair
11. Small, Smac-like molecule encourages death of cancer cells

Post Your Comments:

(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
(Date:6/28/2020)... Fla. (PRWEB) , ... June 25, 2020 , ... In ... focus on innovations in accelerated Point of Care Testing solutions (POCT). Check local listings ... Samples are collected at medical offices and are shipped to labs throughout the country. ...
(Date:6/23/2020)... ... 23, 2020 , ... Rigaku Corporation , a global ... a series of TOPIQ webinars, which will cover the Transferable Aspherical Atom Model ... response to social distancing measures that resulted in postponements and cancelations of global ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... July 17, 2020 , ... ... firm for the life sciences and food industries, is pleased to announce that ... Clinical Research – Business Development. , Charles is an accomplished and results-driven sales ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... Technology (MIT) has expanded the company’s exclusive license to include clinical applications ... point-of-care diagnostic market, focusing initially on the SARS-CoV-2 biosensor. CANARY’s™ fast ...
(Date:7/10/2020)... , ... July 09, 2020 , ... ... cell therapy, today announced the hiring of Allen R. Nissenson, M.D., F.A.C.P., as ... oversee the clinical development of Sentien’s lead product, SBI-101. Dr. Nissenson serves ...
(Date:7/7/2020)... , ... July 06, 2020 , ... ... Awards. Entries from Roche, Eli Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts ... Bio-IT World has hosted an elite awards program, highlighting outstanding examples of how ...
Breaking Biology Technology:
Cached News: