HOME >> BIOLOGY >> NEWS
Stem cells toward sperm cells and back again

In experiments with fruit flies, Johns Hopkins scientists have restored the insect's sperm-making stem cells by triggering cells on the way to becoming sperm to reverse course. The unexpected findings are described in the May 13 issue of Science.

Like all stem cells, the fruit fly's sperm-making stem cells can renew themselves or can develop into more specialized cells -- eventually sperm in this case. While a few types of fairly specialized cells can naturally revert to their stem cell origins at times -- think regrowth of salamanders' lost limbs -- the researchers' experiments document what is thought to be one the first clear examples of an artificially triggered reversal of cell fate in an adult creature.

"With a few exceptions, it is thought that once cells start down the path toward specialization, they can't go back," says Erika Matunis, Ph.D., assistant professor of cell biology in Hopkins' Institute for Basic Biomedical Sciences. "But we've clearly shown in fruit flies that lost sperm-making stem cells can be replaced, not by replication of remaining stem cells, but by reversal of more specialized cells."

The Hopkins team studied fruit flies whose "don't-specialize" signal for stem cells can be turned on or off by changing the temperature around them. In experiments to examine what happens when the signal is turned off and then turned back on, second-year graduate student Crista Brawley discovered that cells that are two steps -- but not more -- away from their stem cell origins can revert to the more primitive state.

Understanding how and until what point specialized cells can reverse course might help scientists figure out how to use stem cells to regenerate lost or injured tissue, or how to trigger remaining tissue to better heal itself. There is no immediate application for people, however, because little is known about the corresponding process in humans.

"In fruit flies, we literally can count each stem cell i
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
18-May-2004


Page: 1 2 3

Related biology news :

1. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
2. Researchers develop fast track way to discover how cells are regulated
3. Chemical signals health of brain cells Symposium
4. New dye directly reveals activated proteins in living cells
5. NJIT professor receives Presidential Award for breakthrough research with adult stem cells
6. Complex cells likely arose from combination of bacterial and extreme-microbe genomes
7. Smac-ing back at cancer cells
8. Bone marrow cells routinely help with wound healing
9. Genuine stem cells found in skin might treat hair loss, wounds
10. Skin stem cells give hairless mice hair
11. Small, Smac-like molecule encourages death of cancer cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2020)... ... July 30, 2020 , ... Justin Zamirowski to ... a near term focus on Type 2 diabetes and associated comorbidities. , Justin ... therapeutic areas and classes. As Chief Commercial Officer, Justin will lead Better ...
(Date:7/18/2020)... ... ... Commercial launch readiness is a critical stage in a product life cycle. ... the global economic downturn will only increase price pressures overall for the industry. The ... value from every product launch is critical. However, history shows that only a third ...
(Date:7/4/2020)... PHOENIX (PRWEB) , ... July 03, 2020 , ... ... is proud to earn outstanding recognition and multiple awards for not only the ... the ABM portfolio, SoME® Skincare and Vivace® Microneedle RF. All the brands built ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 30, 2020 , ... ... life sciences industry, today announced the release of its signature product called ... Science Liaisons (MSLs) and other field medical professionals. , Beacon helps ...
(Date:7/18/2020)... ... July 16, 2020 , ... ... in the early detection and prevention of high-burden diseases, and Centric Consulting, a ... and healthcare organizations to utilize existing data in order to identify and prioritize ...
(Date:7/10/2020)... KONG (PRWEB) , ... July 09, 2020 , ... ... compound called 1-phenyl-2-thiourea (PTU) is commonly used to suppress pigment formation in zebrafish ... the PolyU research team led by Dr MA has been using the zebrafish ...
(Date:7/1/2020)... (PRWEB) , ... June 29, 2020 , ... ... year to date growth of 40% in 2020, despite many obstacles created as ... MedShift aims to increase revenue for its partnered medical practices and medical manufacturers ...
Breaking Biology Technology:
Cached News: