HOME >> BIOLOGY >> NEWS
Stem-like cells from peripheral blood restore function in rats with severe stroke

Tampa, FL (July 7, 2003) -- Rats with severe strokes recovered function following intravenous injections of stem-like cells obtained from circulating human blood -- a finding that points to another potential cell therapy for stroke.

The study, by researchers at the University of South Florida Center of Excellence for Aging and Brain Repair, appears in today's issue of the journal Cell Transplantation.

The human blood donors were injected with granulocyte stimulating factor (G-CSF) to stimulate the release of stem-like cells from their bone marrow into the bloodstream before a blood sample was collected. These stem-like cells are known as peripheral blood progenitor cells.

"This is the first demonstration that G-CSF stimulated peripheral blood cells promote functional recovery after a stroke," said Alison Willing, PhD, assistant professor of neurosurgery and first author of the study. "We were putting these cells into animals 24 hours after a stroke and seeing significant behavioral improvement. The animals behaved almost normally on our tests, just as they had before the stroke. That's pretty amazing."

G-CSF stimulated peripheral blood cells have become an alternative treatment to bone marrow transplants for patients with blood cancers. They are easier to obtain, lead to faster recovery from chemotherapy and better survival.

Dr. Willing and her colleagues wanted to explore whether G-CSF treated peripheral blood cells might also be a treatment for central nervous system disorders. For the last few years, the USF Center for Aging and Brain Repair has been investigating alternatives to human embryonic stem cells, such as adult bone marrow stem cells and human umbilical cord blood (HUCB) cells, as treatments for stroke, spinal cord injury and other neurological disorders.

"Our findings suggest that mobilized peripheral blood cells might be a good candidate for early treatment of central nervous system disorders like st
'"/>

Contact: Marissa Emerson
memerson@hsc.usf.edu
813-974-3300
University of South Florida Health
6-Jul-2003


Page: 1 2 3

Related biology news :

1. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
2. Researchers develop fast track way to discover how cells are regulated
3. Chemical signals health of brain cells Symposium
4. New dye directly reveals activated proteins in living cells
5. NJIT professor receives Presidential Award for breakthrough research with adult stem cells
6. Complex cells likely arose from combination of bacterial and extreme-microbe genomes
7. Smac-ing back at cancer cells
8. Bone marrow cells routinely help with wound healing
9. Genuine stem cells found in skin might treat hair loss, wounds
10. Skin stem cells give hairless mice hair
11. Small, Smac-like molecule encourages death of cancer cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 25, 2020 , ... Mitotech ... partnership with Essex Bio-Technology, a bio-pharmaceutical company specializing in Ophthalmology and Dermatology, ... of SkQ1 ophthalmic solution in patients with moderate to severe Dry Eye ...
(Date:8/21/2020)... ... August 18, 2020 , ... Sentien Biotechnologies, Inc., a ... U.S. Food and Drug Administration (FDA) has approved the company’s Investigational New Drug ... of severe COVID-19. Approval of this IND allows Sentien to initiate a Phase ...
(Date:8/12/2020)... ... August 11, 2020 , ... Both Roche, based in ... into license agreements with Housey Pharma’s HMI subsidiary to gain access to its ... annual Research and Development spending in excess of US $10 billion. , Scientists ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... ... ... Introducing Ardent Animal Health – MediVet Biologics rebrands company and positions its ... MediVet Biologics since its formation in 2016, the company is relaunching itself under the ... on its base of innovative therapies for osteoarthritis and cancer. , ...
(Date:7/31/2020)... ... July 29, 2020 , ... Anomet Products has introduced new ... for use with CRM, neurostimulation, vascular, and related devices. , Anomet Medical ... requirements, performance, and cost criteria; especially where solid wire is limited. Typical configurations ...
(Date:7/31/2020)... (PRWEB) , ... July 30, ... ... of cloud-based software for the life sciences industry, today announced the release ... platform designed specifically for Medical Science Liaisons (MSLs) and other field medical ...
(Date:7/18/2020)... Ohio (PRWEB) , ... July 16, 2020 , ... ... data solutions to aid in the early detection and prevention of high-burden diseases, ... to enable US-based hospitals and healthcare organizations to utilize existing data in order ...
Breaking Biology Technology:
Cached News: