Strep disrupts blood clotting to infect humans

ANN ARBOR, Mich.---University of Michigan researchers have captured a glimpse of the endless arms race between infectious agents and the human immune system in a bacterium that uses a mimic of a human blood-clotting enzyme to advance its infection.

Streptococcal bacteria use an enzyme called streptokinase to block the blood clotting response and allow themselves to move more freely around the human host's circulatory system. The molecule is so specific, it only works on humans, not on other animals.

"The theory is that, as bacteria cause a local infection and begin to grow, the clotting system produces clots in the blood vessels around the infection, closing the highways that the bacteria would use to spread," said David Ginsburg, a research professor at the U-M Life Sciences Institute and a Howard Hughes Medical Institute investigator.

"You can see how one bacterial species and one host get locked in this evolutionary dance and would evolve apart from other host-bacterial pairs---ending up with a multitude of variants of streptococci, one for each host.

"This evolutionary mechanism probably functions for many other pathogenicity factors, not just streptokinase, and probably underlies the species-specificity of all kinds of infectious organisms," Ginsburg said.

"The bacterial streptokinase enzyme bypasses this blood-clotting system by causing the blood clot to dissolve so the bacteria can spread," Ginsburg said. Streptokinase secreted by group A streptococcus works by activating the human form of the enzyme plasminogen, which routinely dissolves blood clots in the body.

Human plasminogen is specific to our species, so U-M postdoctoral fellow Hongmin Sun had to develop a genetically engineering humanized mouse that made significant amounts of human plasminogen to test the researchers' ideas about group A streptococci.

Ginsburg adds that making this mouse susceptible to human-type streptococcus infection

Contact: Karl Leif Bates
University of Michigan

Page: 1 2

Related biology news :

1. Streptococcus infects humans by thwarting blood clotting
2. Ketek (Telithromycin) highly active in vitro against Streptococcus pneumoniae
3. Blood Test Can Identify Some Children With Strep-Related Behavioral Disorders
4. To avoid detection, HIV disrupts immune cell migration
5. Popular weed killer disrupts frogs sexual development
6. Popular weed killer demasculinizes frogs, disrupts their sexual development
7. Stratified seawater disrupts the transport of imposex substances
8. Experimental drug shown to block mutant protein causing blood disease
9. IBD (Crohns, Colitis) joins cancer, inflammatory diseases in associated blood vessel growth
10. A probable cause for high blood pressure identified - shows links with diabetes
11. Probing the surface of white blood cells to enhance immune system medicine

Post Your Comments:

(Date:3/10/2020)... ... March 10, 2020 , ... Cytonus Therapeutics Inc. ... Narasimhan is Senior Vice President of Strategic Initiatives, Portfolio Innovation and Investor Relations ... of Cytonus, we are extremely pleased to welcome Manisha Narasimhan as an independent ...
(Date:3/5/2020)... (PRWEB) , ... March 05, ... ... announces the formation of its Scientific Advisory Board (SAB) comprised of the ... institutions, immune-oncology centers, cell therapy centers, and private industry. Cytonus is a ...
(Date:3/5/2020)... BOSTON (PRWEB) , ... March 05, 2020 , ... ... its AlphaSTEM Test™ technology . The AlphaSTEM Test™ is the first, ... tissue stem cells. Other technologies that attempt to provide information about the ...
Breaking Biology News(10 mins):
(Date:3/3/2020)... ... March 03, 2020 , ... Ideal Implant Incorporated Founder ... implant technology at the IMCAS Innovation Shark Tank 2020 in Paris, France in ... surgery, and aesthetic science industries that promise to revolutionize medical practices in their ...
(Date:2/28/2020)... ... February 26, 2020 , ... ... a high-speed camera with a dedicated controller, thus simplifying setup, streamlining integration, and ... HS7 is the first of Fastec Imaging’s new HS Series cameras to be ...
(Date:2/21/2020)... Ontario (PRWEB) , ... February 20, 2020 , ... In ... GMT/UK) join guest speakers from Synteract including Lisa Dilworth, BS, MS, Vice ... discussion about these challenges, with feasible strategies and solutions to support patients, sites and ...
(Date:2/21/2020)... N.Y. (PRWEB) , ... February 20, 2020 , ... ... for ensuring supply chain transparency and reassuring consumers that what’s listed on an ... and trademarked ingredients, Nutrition21 has introduced this solution with the adoption of CertainT, ...
Breaking Biology Technology:
Cached News: