HOME >> BIOLOGY >> NEWS
Stress hormones and heart failure

A hormone that helps the body adapt to stress may provide a key to designing treatments for congestive heart failure, according to a study by researchers at the Salk Institute for Biological Studies and the University of California, San Diego (UCSD) School of Medicine.

Published in the March 9 issue of Proceedings of the National Academy of Sciences, the study establishes a firm link between a family of stress hormones called urocortins and heart disease, and may lead to new treatments for heart failure. Congestive heart fa

ilure is an increasingly common condition among Americans, currently contributing to the deaths of more than 250,000 people annually. The ailment is marked by an impairment of heart muscle function, which eventually leads to a loss in the ability of the heart to pump blood. The known causes of congestive heart failure are multiple, and can be either acquired or inherited. In some individuals, the cause is unknown.

Wylie W. Vale, Helene MacLoraine Professor of Molecular Neurobiology at the Salk, Dr. Kirk L. Peterson, UCSD Edith and William Perlman Professor of Clinical Cardiology, and their colleagues found that a specific member of the urocortin family of proteins, called urocortin II, administered intravenously in a small dose, significantly enhanced heart muscle cell contractions in mice. The hormone bound to a receptor molecule called CRF2 on muscle cells. Mice bred specifically to lack the CRF2 receptor showed no response to urocortin II and higher than normal blood pressure

In addition, mice that were bred to exhibit a form of congestive heart failure were found to have a dramatic improvement in their cardiovascular function when treated with urocortin II.

"We hope that this study expands our understanding of the potent actions of urocortin II in cardiovascular physiology and points to a precise targeting of the CRF2 receptor for improved treatment of heart diseases," Vale s
'"/>

Contact: Andrew Porterfield
porterfield@salk.edu
858-453-4100 ex 1340
Salk Institute
10-Mar-2004


Page: 1 2

Related biology news :

1. Stressed intestine can give rise to food allergy
2. Stress, infertility linked in study by Magee-Womens Research Institute
3. Stress delays puberty
4. Stressed-out mice offer clues to depression, anxiety, anorexia
5. Stress Increases Blood Chemical Related To Heart Disease
6. Researchers Identify Mechanism That May Regulate Protein Involved In Sex Differentiation, Stress, Hunger
7. Investigators Identify Suspect In Search For Stress-Sniffles Link
8. Study Suggests Maternal Stress And Stress Hormones May Influence Fetal Brain Development In Utero
9. Substance Abuse May Curb Bodys Stress Reactions
10. Stress Hormone Levels Predict Length Of Gestation In Human Pregnancy
11. Study Finds Evidence Linking The Brains Cognitive Control Regions With Stress Control Regions

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/5/2019)... ... July 05, 2019 , ... SteriTrack Inc. is ... Platform to governments around the world. , Powered by Microsoft Azure, the ... care solutions to operating theatres worldwide to address new global regulations mandating all ...
(Date:6/24/2019)... ... ... According to the World Health Organization , over a million people ... trichomoniasis (or "trich") and syphilis. And that’s not counting HIV. , In 2017, ... the largest number of HIV diagnoses (9,807), followed by Hispanic/Latino men (7,436) and White ...
(Date:6/18/2019)... LONG BEACH, Calif. (PRWEB) , ... June 18, ... ... provider of multi-GPU deep learning cloud solutions, today introduced Data Science Workstations-as-a-Service as ... data science workstation hardware from BOXX Technologies, Cirrascale Data Science Workstations feature NVIDIA® ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... Va. (PRWEB) , ... June 11, 2019 , ... ... microlearning engagement, and Carilion Clinic, a national leader in opioid treatment, announced today ... virtual care. , Mytonomy recently deployed its virtual care platform at ...
(Date:5/31/2019)... , ... May 29, 2019 ... ... patent applications from the USPTO providing proprietary interest to our methodology, processes, ... SLEEP DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP rights including our proprietary ...
(Date:5/21/2019)... ... May 21, 2019 , ... DuPont ... officially opened the inaugural Africa Brewing Conference dedicated to sharing brewing knowledge, strengthening ... The event, which is supported through a partnership with “Ethiopia Invest”, will run ...
(Date:5/8/2019)... ... , ... Standing at 16.2 hands, Atlas is on the large side for a Quarter Horse. ... racing, among other activities. When loping around a corner in late 2017, Atlas tripped ... horse to only being able to walk. Fortunately Atlas’ owner, Kelly, sought the opinion ...
Breaking Biology Technology:
Cached News: