HOME >> BIOLOGY >> NEWS
Stressed-out mice offer clues to depression, anxiety, anorexia

EDITORS: Color photographs of mice in the experimental maze are available on request.

ANN ARBOR---Stressed-out mice created at the University of Michigan Medical School are helping scientists understand how a hormone that triggers the body's fight-or-flight response to stress also may be involved in depression, anxiety disorders and anorexia.

U-M scientists created the new mouse strain by deleting a gene that controls production of one protein. This protein binds to corticotropin-releasing hormone or CRH, a key neuroregulatory hormone produced by all mammals under stress. Binding prevents CRH from activating receptors that trigger the release of other stress hormones, as well as changes in metabolism and behavior.

Male mice without the gene for CRH-binding protein gained less weight and showed more anxiety-like behavior than littermates that could produce the protein.

"These mice exhibit anxiety-like behavior all the time---not just in response to an external stressor," says Audrey F. Seasholtz, Ph.D., a senior associate research scientist in the U-M's Mental Health Research Institute and an associate professor of biological chemistry in the U-M Medical School.

The initial U-M study documenting behavioral changes in mice without CRH-binding protein will be published in the Sept. 28 issue of the Proceedings of the National Academy of Sciences.

In the study, Seasholtz and her U-M colleagues used standard tests to document levels of stress hormones and anxiety-like behavior in mice without the gene for CRH-binding protein and compare them to test results in normal littermate controls.

Even though they were housed together and given identical access to food and water, male mice without the CRH-BP gene gained less weight between 7-9 weeks of age than did male control mice. Weight gain differences between experimental males and controls became even more significant from 10 to 15 week
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
734-647-1844
University of Michigan
28-Sep-1999


Page: 1 2 3

Related biology news :

1. Lake research offers clues to managing crayfish invasions
2. Comparing primate genomes offers insight into human evolution
3. UW study: Migrating birds offer insight into sleep
4. Only 21 states offer newborn screening tests recommended by March of Dimes
5. Study of proteins offers insights into organization of biological networks
6. Susceptibility of mice to mousepox offers promise of smallpox protection
7. Discovery in parasite movement may offer insights into malaria
8. Botulinum toxin structure offers clues for vaccines/treatments
9. Discovery offers clues to origin of life
10. Guiding gas exploration: U-M research offers inexpensive tool
11. A multi-institutional study may offer clues for the treatment of some autoimmune diseases

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: