HOME >> BIOLOGY >> NEWS
Stressed-out mice offer clues to depression, anxiety, anorexia

EDITORS: Color photographs of mice in the experimental maze are available on request.

ANN ARBOR---Stressed-out mice created at the University of Michigan Medical School are helping scientists understand how a hormone that triggers the body's fight-or-flight response to stress also may be involved in depression, anxiety disorders and anorexia.

U-M scientists created the new mouse strain by deleting a gene that controls production of one protein. This protein binds to corticotropin-releasing hormone or CRH, a key neuroregulatory hormone produced by all mammals under stress. Binding prevents CRH from activating receptors that trigger the release of other stress hormones, as well as changes in metabolism and behavior.

Male mice without the gene for CRH-binding protein gained less weight and showed more anxiety-like behavior than littermates that could produce the protein.

"These mice exhibit anxiety-like behavior all the time---not just in response to an external stressor," says Audrey F. Seasholtz, Ph.D., a senior associate research scientist in the U-M's Mental Health Research Institute and an associate professor of biological chemistry in the U-M Medical School.

The initial U-M study documenting behavioral changes in mice without CRH-binding protein will be published in the Sept. 28 issue of the Proceedings of the National Academy of Sciences.

In the study, Seasholtz and her U-M colleagues used standard tests to document levels of stress hormones and anxiety-like behavior in mice without the gene for CRH-binding protein and compare them to test results in normal littermate controls.

Even though they were housed together and given identical access to food and water, male mice without the CRH-BP gene gained less weight between 7-9 weeks of age than did male control mice. Weight gain differences between experimental males and controls became even more significant from 10 to 15 week
'"/>

Contact: Sally Pobojewski
pobo@umich.edu
734-647-1844
University of Michigan
28-Sep-1999


Page: 1 2 3

Related biology news :

1. Lake research offers clues to managing crayfish invasions
2. Comparing primate genomes offers insight into human evolution
3. UW study: Migrating birds offer insight into sleep
4. Only 21 states offer newborn screening tests recommended by March of Dimes
5. Study of proteins offers insights into organization of biological networks
6. Susceptibility of mice to mousepox offers promise of smallpox protection
7. Discovery in parasite movement may offer insights into malaria
8. Botulinum toxin structure offers clues for vaccines/treatments
9. Discovery offers clues to origin of life
10. Guiding gas exploration: U-M research offers inexpensive tool
11. A multi-institutional study may offer clues for the treatment of some autoimmune diseases

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... ... July 08, 2020 , ... Overcoming Comparability Issues in ... FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 p.m.-3:00 p.m. EDT, https://www.fdanews.com/cellandgenetherapy ... most effective way to complete one? Will the study comply with all FDA ...
(Date:7/2/2020)... ... July 02, 2020 , ... ... B.V. (MBS) has announced a publication detailing the use of its revolutionary ... polymerase chain reaction (RT-PCR) in 16 minutes. The article, titled "Ultra-fast one-step ...
(Date:6/28/2020)... ... June 25, 2020 , ... In an upcoming episode scheduled for the fall ... Care Testing solutions (POCT). Check local listings for more info. , Today, the majority ... are shipped to labs throughout the country. Results are then available several days later. ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... ... ... True Terpenes , the leading platform for terpene innovation, research and ... the medical potential of terpenes and the potential entourage effect , where the ... focused on expanding the recently launched line of effects-based terpenes - Terpology by ...
(Date:8/12/2020)... ... August 12, 2020 , ... ... International), a global leader in FDA compliance consulting has been named on its ... companies. The list represents a unique look at the most successful companies within ...
(Date:7/31/2020)... ... ... R3 Stem Cell International is now offering patients the opportunity to receive four ... may choose which extremities they would like treated. , Several studies have shown just ... R3 International, umbilical cord tissue is obtained from a lab with a long history ...
(Date:7/31/2020)... SOMERSET, N.J (PRWEB) , ... July 29, 2020 ... ... editing company, and Catalent, the leading global provider of advanced delivery technologies, development, ... products, today announced that they have entered into a strategic partnership whereby Catalent ...
Breaking Biology Technology:
Cached News: