HOME >> BIOLOGY >> NEWS
Strikingly Similar protein may be in Alzheimers and Mad Cow Disease

ATTENTION ALL REPORTERS: The research findings cited in this release were not presented at the American Chemical Society national meeting because the researcher was not available to make the presentation.

Washington D.C., August 23 -- A "striking similarity" between proteins involved in the early stages of Alzheimer's disease and mad cow disease was described here today at the 220th national meeting of the American Chemical Society, the world's largest scientific society. The theory, if verified by other researchers, could help focus efforts to develop preventive drugs, according to the study's lead researcher, Chi Ming Yang, Ph.D., a professor of chemistry at Nankai University in Tianjin, China.

Prion diseases which include, among others, neurodegenerative diseases such as mad cow disease and its human counterpart, Creutzfeldt-Jakob disease are caused by a malfunctioning prion protein. In Alzheimer's disease, another neurodegenerative disease, the amyloid precursor protein has been implicated.

Using computer modeling, Yang discovered a similar pattern of amino acids in the prion protein and the amyloid precursor protein: a reductive amino acid followed by three non-reductive amino acids.

"This suggests a common molecular mechanism underlying the initiation stages of sporadic Alzheimer's disease and both sporadic and genetic prion diseases," says Yang.

Reductive amino acids are more prone to damage by oxygen-containing free radicals (molecules with a highly reactive unpaired electron) than other amino acids, explained Yang. Normally, the body can clear itself of free radicals. But with age, this system may fail. When enough free radicals accumulate to damage a protein molecule, it can malfunction, he says.

Proteins typically fold into specific three-dimensional structures that determine their functions. A malfunctioning protein may remain partially unfolded,
'"/>

Contact: Charmayne Marsh
c_marsh@acs.org
202-872-4445
American Chemical Society
23-Aug-2000


Page: 1 2

Related biology news :

1. Similar genetic origins possible for schizophrenia and bipolar disorder
2. Fossil Footprints Show Foot-Movement Similarity In Dinosaurs And Birds
3. Researchers Show Mechanism And Similarities Of Biological Clocks
4. Similarities Found In Human, Chimp Brains; Columbia, Mount Sinai, NIH Scientists Find Region That Controls Language Identical In Both Species
5. Proteins Interacting With RNA And DNA Are Surprisingly Similar
6. New molecular link key to cellular proteins involved in cancer progression, other diseases
7. Researchers identify protein promoting vascular tumor growth
8. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
9. Experimental drug shown to block mutant protein causing blood disease
10. Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction
11. Images of tail of protein needed for cell multiplication suggest anticancer drug targets

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... -- KEY FINDINGS The global market for ... of 25.76% during the forecast period of 2017-2025. The ... the growth of the stem cell market. ... INSIGHTS The global stem cell market is segmented on ... stem cell market of the product is segmented into ...
(Date:3/30/2017)... KONG , March 30, 2017 The ... a system for three-dimensional (3D) fingerprint identification by adopting ground breaking ... into a new realm of speed and accuracy for use in ... at an affordable cost. ... ...
(Date:3/27/2017)... 27, 2017  Catholic Health Services (CHS) has ... Society (HIMSS) Analytics for achieving Stage 6 on ... . In addition, CHS previously earned a place ... an electronic medical record (EMR). "HIMSS ... of EMR usage in an outpatient setting.  This ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... June 22, 2017 , ... ... designating infertility as a disease, bringing new hope for prospective parents who are ... annual meeting to back the World Health Organization’s designation in hopes of changing ...
(Date:6/22/2017)... ... ... Charm Sciences, Inc. is pleased to announce that its Charm Amphenicol (AMPH) test ... screening test at dairies and farms for raw commingled cow milk. The test was ... system. These systems are a combination incubator and reader in one. , “The AMPH ...
(Date:6/20/2017)... ... June 20, 2017 , ... National executive ... leader with extensive assay development and biomarker expertise, as VP of Scientific Affairs ... CRO specializing in bio-analytical assay development and sample testing services. The organization acts ...
(Date:6/19/2017)... ... June 19, 2017 , ... Tunnell Consulting has been ... One of the biggest challenges faced by life sciences, biotech and pharmaceuticals companies today ... is Kati Abraham , who is well known in the industry and brings ...
Breaking Biology Technology:
Cached News: