Structure Of Tumor Necrosis Factor-Alpha-Converting Enzyme Solved - Milestone Toward Rational Drug Design For Rheumatoid Arthritis And Endotoxic Shock

A research group of the Department for Structural Research at the Max Planck Institute of Biochemistry in Martinsried c/o Munich, Germany, in cooperation with scientists from Immunex/Seattle, Wyeth-Ayerst/New York, and the Max Planck Research Unit for Proteindynamics in Hamburg solved the crystal structure of the catalytic domain of human necrosis factor-a-converting enzyme (TACE).

TACE is a membrane-bound metalloproteinase localized on the outer surface of virtually every cell of the human body. This multidomain zinc enzyme has recently been identified to cleave the membrane-bound precursor of the tumor necrosis factor-a (proTNFa) of mononuclear phagocytes, B and T-cells, mast cells and killer cells. The liberated TNFa is the major cytokine that induces protective inflammatory reactions against bacteria such as Salmonella and kills tumor cells, but also causes severe tissue damage when produced in excess such as in rheumatoid arthritis, transplant rejection, multiple sclerosis, organ failure or septic shock, and also promotes HIV production in monocytes. Due to TACEs role in TNFa conversion, inhibitors of TACE would affect the release of soluble TNFa into circulation.

The Max Planck team (Dr. Klaus Maskos, Carlos Fernandez-Catalan, Marianne Braun and Prof. Wolfram Bode) was able to crystallize the recombinant catalytic domain of TACE cloned and purified by the Immunex team (headed by Dr. Roy Black), and to solve its structure using synchrotron radiation a

Contact: Wolfram Bode
+49-89-8578 2676

Page: 1 2

Related biology news :

1. Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
2. Structure solved by Scripps scientists shows one way that body controls gene expression
3. Structure of a Nobel-prize winning molecule: Aquaporin
4. Structure of HIV-neutralizing antibody solved
5. Structure of key breast cancer receptor determined
6. Structure of cog at the hub of metabolism reveals anti-ageing function
7. Structure of pain-modulating enzyme described by scientists at the Scripps Research Institute
8. Structure reveals details of cells cargo-carriers
9. Structure of key receptor unlocked; Related proteins will fall like dominoes
10. New Science Press launches Proteins: From Sequence to Structure
11. Third piece completes deadly puzzle: Structure of anthrax toxin offers clues to treatment

Post Your Comments:

(Date:6/4/2019)... TORONTO (PRWEB) , ... June 04, 2019 , ... ... automate the search for salient features of seizure risk signals, usually based on ... neurologist-driven EEG interpretation remains the only acceptable diagnostic methodology due to the complexity ...
(Date:6/1/2019)... ... May 31, 2019 , ... ... & Rosati recently invested in BioFactura’s $6M Series B Financing Round. , ... value-added institutional investors who bring significant financial and business resources to bear as ...
(Date:5/31/2019)... ... 30, 2019 , ... Join Julie Peacock, Vice President of ... Wednesday, June 19, 2019 at 1pm EDT where she will demonstrate how role-based ... and contract research organizations (CROs) can improve collaboration, auditing, document tracking and reporting. ...
Breaking Biology News(10 mins):
(Date:7/2/2019)... (PRWEB) , ... July 02, 2019 , ... Leading Regenerative ... entitled Animal Pharm: Where Beasts Meet Biotech. The film focuses on regenerative veterinary ... animals. Animal Pharm was recently included in the Brentwood and Pacific ...
(Date:6/11/2019)... ... 2019 , ... Thought Technology Ltd is pleased to announce ... Tech Ltd as its authorised distributor for the UK and Ireland. , ... and clinical assessment protocols to treat stress related disorders as well as provide ...
(Date:6/11/2019)... ... June 11, 2019 , ... A ... mesenchymal stem cells (MSC-EV) are able to incorporate into human CD34+ cells, modifying ... on mice, MSC-EVs also increased the cells’ ability to lodge into bone marrow. ...
(Date:5/31/2019)... NEWPORT BEACH, Calif. (PRWEB) , ... May 30, ... ... the future of neurotoxins, is pleased to announce the strategic acquisition of Metabiologics, ... for research. The acquisition provides Object exclusive ownership and commercialization rights to a ...
Breaking Biology Technology:
Cached News: