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Structure Of Tumor Necrosis Factor-Alpha-Converting Enzyme Solved - Milestone Toward Rational Drug Design For Rheumatoid Arthritis And Endotoxic Shock


A research group of the Department for Structural Research at the Max Planck Institute of Biochemistry in Martinsried c/o Munich, Germany, in cooperation with scientists from Immunex/Seattle, Wyeth-Ayerst/New York, and the Max Planck Research Unit for Proteindynamics in Hamburg solved the crystal structure of the catalytic domain of human necrosis factor-a-converting enzyme (TACE).

TACE is a membrane-bound metalloproteinase localized on the outer surface of virtually every cell of the human body. This multidomain zinc enzyme has recently been identified to cleave the membrane-bound precursor of the tumor necrosis factor-a (proTNFa) of mononuclear phagocytes, B and T-cells, mast cells and killer cells. The liberated TNFa is the major cytokine that induces protective inflammatory reactions against bacteria such as Salmonella and kills tumor cells, but also causes severe tissue damage when produced in excess such as in rheumatoid arthritis, transplant rejection, multiple sclerosis, organ failure or septic shock, and also promotes HIV production in monocytes. Due to TACEs role in TNFa conversion, inhibitors of TACE would affect the release of soluble TNFa into circulation.

The Max Planck team (Dr. Klaus Maskos, Carlos Fernandez-Catalan, Marianne Braun and Prof. Wolfram Bode) was able to crystallize the recombinant catalytic domain of TACE cloned and purified by the Immunex team (headed by Dr. Roy Black), and to solve its structure using synchrotron radiation a
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Contact: Wolfram Bode
bode@biochem.mpg.de
+49-89-8578 2676
Max-Planck-Gesellschaft
6-Apr-1998


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