HOME >> BIOLOGY >> NEWS
Structure Of Tumor Necrosis Factor-Alpha-Converting Enzyme Solved - Milestone Toward Rational Drug Design For Rheumatoid Arthritis And Endotoxic Shock


A research group of the Department for Structural Research at the Max Planck Institute of Biochemistry in Martinsried c/o Munich, Germany, in cooperation with scientists from Immunex/Seattle, Wyeth-Ayerst/New York, and the Max Planck Research Unit for Proteindynamics in Hamburg solved the crystal structure of the catalytic domain of human necrosis factor-a-converting enzyme (TACE).

TACE is a membrane-bound metalloproteinase localized on the outer surface of virtually every cell of the human body. This multidomain zinc enzyme has recently been identified to cleave the membrane-bound precursor of the tumor necrosis factor-a (proTNFa) of mononuclear phagocytes, B and T-cells, mast cells and killer cells. The liberated TNFa is the major cytokine that induces protective inflammatory reactions against bacteria such as Salmonella and kills tumor cells, but also causes severe tissue damage when produced in excess such as in rheumatoid arthritis, transplant rejection, multiple sclerosis, organ failure or septic shock, and also promotes HIV production in monocytes. Due to TACEs role in TNFa conversion, inhibitors of TACE would affect the release of soluble TNFa into circulation.

The Max Planck team (Dr. Klaus Maskos, Carlos Fernandez-Catalan, Marianne Braun and Prof. Wolfram Bode) was able to crystallize the recombinant catalytic domain of TACE cloned and purified by the Immunex team (headed by Dr. Roy Black), and to solve its structure using synchrotron radiation a
'"/>

Contact: Wolfram Bode
bode@biochem.mpg.de
+49-89-8578 2676
Max-Planck-Gesellschaft
6-Apr-1998


Page: 1 2

Related biology news :

1. Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
2. Structure solved by Scripps scientists shows one way that body controls gene expression
3. Structure of a Nobel-prize winning molecule: Aquaporin
4. Structure of HIV-neutralizing antibody solved
5. Structure of key breast cancer receptor determined
6. Structure of cog at the hub of metabolism reveals anti-ageing function
7. Structure of pain-modulating enzyme described by scientists at the Scripps Research Institute
8. Structure reveals details of cells cargo-carriers
9. Structure of key receptor unlocked; Related proteins will fall like dominoes
10. New Science Press launches Proteins: From Sequence to Structure
11. Third piece completes deadly puzzle: Structure of anthrax toxin offers clues to treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2017)...   ivWatch LLC , a medical device company focused on ... receipt of its ISO 13485 Certification, the global standard for medical ... Standardization (ISO®). ... Continuous Monitoring device for the early detection of IV infiltrations. ... "This is an important milestone for ivWatch, as ...
(Date:6/14/2017)... IBM ) is introducing several innovative partner startups at ... between startups and global businesses, taking place in ... startups will showcase the solutions they have built with IBM ... France is one of the most ... increase in the number of startups created between 2012 and ...
(Date:5/6/2017)... May 5, 2017 RAM Group ... a new breakthrough in biometric authentication based on ... mechanical properties to perform biometric authentication. These new sensors ... material created by Ram Group and its partners. This ... transportation, supply chains and security. Ram Group is ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that give it exclusive ... a technology developed in collaboration with Children’s Hospital Los Angeles (CHLA). ...
(Date:10/10/2017)... -- International research firm Parks Associates announced today that ... TMA 2017 Annual Meeting , October 11 in Scottsdale, Arizona ... market and how smart safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase ... "The residential security market has experienced continued growth, ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program Committee is ... honoring scientists who have made outstanding contributions to analytical chemistry and applied spectroscopy. ... world’s leading conference and exposition for laboratory science, which will be held February ...
(Date:10/9/2017)... ... October 09, 2017 , ... At its national board meeting ... a professor in Harvard University’s Departments of Physics and Astronomy, has been selected for ... of the winning team for the 2015 Breakthrough Prize in Fundamental physics for the ...
Breaking Biology Technology:
Cached News: