HOME >> BIOLOGY >> NEWS
Structure of cog at the hub of metabolism reveals anti-ageing function

The structure of a key energy-releasing enzyme found in all animals is designed to minimise free radical production, an international team of researchers report in the journal Science today.

In a startling feat of structural biology, the team visualised the entire molecular structure of succinate dehydrogenase in the bacterium E. coli, allowing them to see for the first time how the protein's three-dimensional shape helps prevent the formation of large quantities of these destructive oxygen atoms.

Formed as a by-product during cellular respiration, free radical can cause havoc in cells by reacting with DNA or the cell membrane, knocking out or impairing their function, a process linked to cellular ageing.

Professor Paul Fremont, Director of Imperial's Centre for Structural Biology, said: "Professor Iwata's group have performed an extraordinary feat in obtaining the first three-dimensional insights of succinate dehydrogenase.

"This fundamentally important and highly complex metabolic enzyme protects the bacterium from self inflicted damage and lies at the heart of the cell's energy powerhouse. It acts like a built in anti-pollution system, and has significant implications for understanding human ageing."

Professor So Iwata of Imperial College London, senior author of the paper added: "Solving the structure of succinate dehydrogenase opens up new leads in the quest to understand longevity and ageing.

"It now appears that a wide variety of genetic disorders including muscle and neurodegenerative diseases, and tumour formation, are caused by defective forms of this enzyme - as a result of increased free radical formation."

"The challenge now is to try and engineer succinate dehydrogenase to maximise its efficiency. The E. coli bacterium provides a flexible model to advance this research because the enzyme is very similar to the human version."

Cellular respiration is the process of oxidizing food m
'"/>

Contact: Judith H. Moore
j.h.moore@imperial.ac.uk
44-207-594-6702
Imperial College London
30-Jan-2003


Page: 1 2

Related biology news :

1. Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
2. Structure solved by Scripps scientists shows one way that body controls gene expression
3. Structure of a Nobel-prize winning molecule: Aquaporin
4. Structure of HIV-neutralizing antibody solved
5. Structure of key breast cancer receptor determined
6. Structure of pain-modulating enzyme described by scientists at the Scripps Research Institute
7. Structure reveals details of cells cargo-carriers
8. Structure of key receptor unlocked; Related proteins will fall like dominoes
9. New Science Press launches Proteins: From Sequence to Structure
10. Third piece completes deadly puzzle: Structure of anthrax toxin offers clues to treatment
11. Structure of key protein involved in cancer, osteoporosis and foot-and-mouth disease finally solved

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Structure cog the hub metabolism reveals anti ageing function

(Date:7/31/2014)... have completed a 20-year study that looks at ... different times of the year. It finds that ... frame has no measurable negative consequences for the ... , The study was conducted by Gene Towne, ... fire chief, and Joseph Craine, research assistant professor, ...
(Date:7/31/2014)... An experimental vaccine protected 100 percent of animal models ... difficile , which causes an intestinal disease that kills ... of print in Infection and Immunity . ... and non-human primates against the purified toxins produced by ... orogastric spore infection, a laboratory model that mimics the ...
(Date:7/31/2014)... discovered the photovoltaic effect in 1839, humankind has sought ... for its own purposes. In a new research report ... FASEB Journal , scientists may have uncovered ... by focusing on a naturally occurring combination of lipids ... persistence over time and across speciessuggests that this specific ...
Breaking Biology News(10 mins):Study finds benefits to burning Flint Hills prairie in fall and winter 2Study finds benefits to burning Flint Hills prairie in fall and winter 3C. difficile vaccine proves safe, 100 percent effective in animal models 2Scientists shine bright new light on how living things capture energy from the sun 2
(Date:8/1/2014)... CHICAGO , Aug. 1. 2014 As ... U.S., the 2014 AACC Annual Meeting & Clinical Lab ... testing and patient care are introduced to the healthcare ... by the Expo,s 650 exhibitors will include the latest ... Advances in smartphones and biosensors have enabled ...
(Date:8/1/2014)... York , August 1, 2014 ... Transparency Market Research "Biophotonics Market - Global Industry Analysis, ... the market was valued at USD 25.16 billion in ... by 2020, growing at a CAGR of 10.4% from ... Market Report at  http://www.transparencymarketresearch.com/biophotonics-market.html Increasing demand ...
(Date:8/1/2014)... Aug. 1, 2014 Cambrex Corporation (NYSE: ... 30, 2014. Highlights , Second ... in the same period last year. , Second quarter ... in the same period last year (see table at the ... guidance increased, excluding the impact of foreign currency, to between ...
(Date:7/31/2014)... “2014 Deep Research Report ... is a professional and in-depth research report ... Polyurethane Resin basic information, including its definition, ... industry overview. This research covers the international ... well as global industry analysis covering macroeconomic ...
Breaking Biology Technology:Lab-on-a-Chip Technology to Be Featured at 2014 AACC Annual Meeting & Clinical Lab Expo 2Lab-on-a-Chip Technology to Be Featured at 2014 AACC Annual Meeting & Clinical Lab Expo 3Global Biophotonics Market is Expected to Reach USD 50.20 Billion in 2020: Transparency Market Research 2Global Biophotonics Market is Expected to Reach USD 50.20 Billion in 2020: Transparency Market Research 3Global Biophotonics Market is Expected to Reach USD 50.20 Billion in 2020: Transparency Market Research 4Cambrex Reports Second Quarter 2014 Financial Results 2Cambrex Reports Second Quarter 2014 Financial Results 3Cambrex Reports Second Quarter 2014 Financial Results 4Cambrex Reports Second Quarter 2014 Financial Results 5Cambrex Reports Second Quarter 2014 Financial Results 6Cambrex Reports Second Quarter 2014 Financial Results 7Cambrex Reports Second Quarter 2014 Financial Results 8Cambrex Reports Second Quarter 2014 Financial Results 9Cambrex Reports Second Quarter 2014 Financial Results 10Cambrex Reports Second Quarter 2014 Financial Results 11Cambrex Reports Second Quarter 2014 Financial Results 12Cambrex Reports Second Quarter 2014 Financial Results 13Cambrex Reports Second Quarter 2014 Financial Results 14Cambrex Reports Second Quarter 2014 Financial Results 15Cambrex Reports Second Quarter 2014 Financial Results 16Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 2Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 3Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 4
Cached News: