Structure of key protein involved in cancer, osteoporosis and foot-and-mouth disease finally solved

Researchers at Massachusetts General Hospital (MGH) have solved the structure of an integrin receptor, a key protein involved in diseases and processes ranging from tumor angiogenesis and breast cancer metastasis to osteoporosis, vascular restenosis and foot-and-mouth disease. The finding, which will appear in Science magazine, was published Sept. 6 on the Science Express website http://www.sciencexpress.org.

"Knowing the shape of this receptor will help us all develop strategies to target many of these diseases," says M. Amin Arnaout, MD, Director of the Structural Biology Program at MGH and Chief of the MGH Renal Unit. The other members of the MGH research team are Jian-Ping Xiong, PhD, Thilo Stehle, PhD, and David Scott, MD, PhD. The new information may be useful in designing novel anti-angiogenic, anti-inflammatory, anti-viral, and anti-osteoporosis drugs that target integrins.

The MGH team of researchers has been trying to decipher the three dimensional structure of this particular integrin receptor for several years. "This is the first look anyone has had at the whole structure of this class of receptors," says Arnaout.

Integrin receptors transmit chemical signals from a cell?s surface into its interior, which regulate most cellular processes such as attachment, proliferation, differentiation, and survival. Integrin receptors also have a unique ability to undergo shape-shifting as they become activated in response to the specialized needs of cells. "Elucidating the basic shape of these receptors is therefore key to understanding their function," says Arnaout.

An activated integrin receptor is able to bind a molecule called a ligand, in a lock and key fashion. Integrin receptors are very promiscuous, though, and they fit a variety of ligand 'keys,' including viral proteins that hijack these receptors to gain entry into cells.

There are many different types of integrin rec

Contact: Susan McGreevey
Massachusetts General Hospital

Page: 1 2

Related biology news :

1. Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
2. Structure solved by Scripps scientists shows one way that body controls gene expression
3. Structure of a Nobel-prize winning molecule: Aquaporin
4. Structure of HIV-neutralizing antibody solved
5. Structure of key breast cancer receptor determined
6. Structure of cog at the hub of metabolism reveals anti-ageing function
7. Structure of pain-modulating enzyme described by scientists at the Scripps Research Institute
8. Structure reveals details of cells cargo-carriers
9. Structure of key receptor unlocked; Related proteins will fall like dominoes
10. New Science Press launches Proteins: From Sequence to Structure
11. Third piece completes deadly puzzle: Structure of anthrax toxin offers clues to treatment

Post Your Comments:

(Date:6/6/2019)... ... June 05, 2019 , ... MedTech Breakthrough , an ... and medical technology market, announced that it has selected Medacta International’s MySpine® MC ... in the 2019 MedTech Breakthrough Awards program. , Medacta® is ...
(Date:6/4/2019)... (PRWEB) , ... June 04, 2019 , ... ... manufacturing of orthopedic medical devices, today announced Q1-19 revenues of $31M, up 12% ... combined with successful roll-out of strategic investments & operational excellence initiatives worldwide. , ...
(Date:6/4/2019)... ... June 04, 2019 , ... Most preclinical EEG ... seizure risk signals, usually based on variations of amplitude, frequency or spike train ... diagnostic methodology due to the complexity and variability of the signal, and automation ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... , ... June 10, 2019 , ... ... and technology in an upcoming episode, scheduled to broadcast 4Q/2019. Check your local ... Group) and will educate viewers about how its technology facilitates laboratories to improve ...
(Date:6/11/2019)... BETHESDA, Md. and ROANOKE, Va. (PRWEB) , ... ... ... virtual care optimized for microlearning engagement, and Carilion Clinic, a national leader in ... leveraging the latest in virtual care. , Mytonomy recently deployed its ...
(Date:6/11/2019)... ... June 11, 2019 , ... A ... mesenchymal stem cells (MSC-EV) are able to incorporate into human CD34+ cells, modifying ... on mice, MSC-EVs also increased the cells’ ability to lodge into bone marrow. ...
(Date:5/31/2019)... ... 2019 , ... For many years, the primary forms of cancer treatment have ... Advances in immuno-oncology have led to the advent of Chimeric Antigen Receptor T (CAR ... receptors known as “CARs”. The CAR enables the final product to produce chemicals in ...
Breaking Biology Technology:
Cached News: