HOME >> BIOLOGY >> NEWS
Structure of key receptor unlocked; Related proteins will fall like dominoes

After two years of stubborn persistence, scientists at Johns Hopkins have determined the 3-D structure of part of a protein called HER3, which should speed efforts to interfere with abnormal growth and cancer.

"It took us more than two years to interpret the data and get HER3's structure," says Dan Leahy, Ph.D., a Howard Hughes Medical Institute investigator and a professor of biophysics in Hopkins' Institute for Basic Biomedical Sciences. "Now that we have it, it might take only weeks to figure out its relatives."

Reporting the structure in the Aug. 1 online version of Science, Leahy says finding out the shapes of the entire HER family of proteins, HER1, HER2 and HER4, will provide the first opportunity to rationally design new drugs to interfere with them, possibly preventing or treating select forms of cancer.

HER2, for example, is the target of the breast cancer treatment Herceptin, an antibody. But while it's an effective life-prolonging treatment in certain breast cancer patients, different strategies targeting HER2 might also prove effective. Having a protein's structure allows scientists to conceive new strategies and pursue new classes of drugs, says Leahy.

A focus of many scientists because of the proteins' involvement in cell growth, the HER family are receptors for "epidermal growth factor" (EGF) and other chemicals. Although the DNA sequences of HER proteins have been known for some time, technical problems dogged efforts to understand how the proteins are shaped, Leahy says.

"Until we know proteins' structures, we're very limited in figuring out how a molecule or possible drug might bind," says Leahy. "We now have a starting point to see how molecules binding to HER3 change its shape and turn it on."

Stuck in the cell membrane, each HER protein consists of three parts: a region outside the cell that recognizes and binds certain molecules; a region that anchors the protein in the cell membrane; and a re
'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
6-Aug-2002


Page: 1 2

Related biology news :

1. Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
2. Structure solved by Scripps scientists shows one way that body controls gene expression
3. Structure of a Nobel-prize winning molecule: Aquaporin
4. Structure of HIV-neutralizing antibody solved
5. Structure of key breast cancer receptor determined
6. Structure of cog at the hub of metabolism reveals anti-ageing function
7. Structure of pain-modulating enzyme described by scientists at the Scripps Research Institute
8. Structure reveals details of cells cargo-carriers
9. New Science Press launches Proteins: From Sequence to Structure
10. Third piece completes deadly puzzle: Structure of anthrax toxin offers clues to treatment
11. Structure of key protein involved in cancer, osteoporosis and foot-and-mouth disease finally solved

Post Your Comments:
(Date:4/17/2014)... Researchers in France have hit on a novel ... receive the correct and most effective treatment possible., ... the western and developing world. If left untreated, ... to renal failure and other complications. In many ... problem. Clearly a more effective pathological approach to ...
(Date:4/17/2014)... recent Yokahama IPCC meeting painted a stark warning on ... which has a greenhouse effect 32 times that of ... shown that humic substances act as fully regenerable electron ... are held in wetlands instead of being released to ... system is disrupted it may enter into a vicious ...
(Date:4/17/2014)... researchers have detected new early-warning signs of the potential ... have far-reaching implications for the diagnosis and treatment of ... million Americans. , "We had not expected to see ... stages," said Ann Elsner, professor and associate dean in ... the study. "We set out to study the early ...
Breaking Biology News(10 mins):Methane climate change risk suggested by proof of redox cycling of humic substances 2New technique detects microscopic diabetes-related eye damage 2New technique detects microscopic diabetes-related eye damage 3
(Date:1/14/2014)... 14, 2014 As pet owners drew up their lists of ... wrote: "Take better care of my furry companion." Nowadays there are ... top-brand carrying cases to take the little canine or feline darlings ... compelled to buy some pricey toys at the pet store. But ...
(Date:1/14/2014)... 2014 iLab Solutions, the leader in core ... Director of Product Strategy. In this role, Michelle will work ... to guide in the development of iLab products. Her main ... possible benefit to the scientific community by offering the most ...
(Date:1/14/2014)... Kinaxis ®, provider of RapidResponse ®, a cloud-based supply ... ( S&OP ) service, is proud to be a gold ... held at the Hilton San Diego Bayfront, January 30 – ... Kaszas , Director of Supply Chain at Amgen, as she ...
(Date:1/14/2014)... 2014 Independent publisher Bitingduck Press, with ... Canada, has big ideas for 2014 in production and ... are to produce high-quality, low-cost, DRM-free ebooks and to ... , The first major development will be bookstore ...
Breaking Biology Technology:New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2Bitingduck Press Looks Forward to 2014 With Multimedia E-books 2
Cached News: