HOME >> BIOLOGY >> NEWS
Structure of key receptor unlocked; Related proteins will fall like dominoes

gion inside the cell that, when activated, adds phosphates to various proteins. Leahy and postdoctoral fellow Hyun-Soo Cho determined the structure of the first of these regions for HER3.

Combining a number of available methods, Leahy, Cho and technician Patti Longo purified large amounts of the HER3 receptor region and formed uniform crystals, crucial for figuring out protein structures. By bombarding the crystals with X-rays at the National Synchrotron Light Source at Brookhaven National Laboratory in New York, Cho got the information he needed to start figuring out how the protein looks in space.

In each crystal there are billions of protein molecules, organized in a careful pattern. As the X-rays travel through the crystal, they hit individual atoms in the protein and are bounced back or bent, depending on the 3-D arrangement of the atoms. Others travel through unaffected. By analyzing where the X-rays end up, the scientists can reconstruct how the protein is put together.

One unexpected aspect of the protein's structure is what Leahy and Cho call the "snap" region -- two finger-like loops that reach out toward one another and interact, stabilizing the structure.

"While it's all speculation right now, it's easy to imagine how losing the "snap" interaction might be involved in binding or activation," Leahy says.

HER1 and HER4 have the same sequence of building blocks in the "snap" region, but HER2 does not, which may help explain why HER2 is the only one of the four receptors that interacts only with other HER proteins.


'"/>

Contact: Joanna Downer
jdowner1@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
6-Aug-2002


Page: 1 2

Related biology news :

1. Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
2. Structure solved by Scripps scientists shows one way that body controls gene expression
3. Structure of a Nobel-prize winning molecule: Aquaporin
4. Structure of HIV-neutralizing antibody solved
5. Structure of key breast cancer receptor determined
6. Structure of cog at the hub of metabolism reveals anti-ageing function
7. Structure of pain-modulating enzyme described by scientists at the Scripps Research Institute
8. Structure reveals details of cells cargo-carriers
9. New Science Press launches Proteins: From Sequence to Structure
10. Third piece completes deadly puzzle: Structure of anthrax toxin offers clues to treatment
11. Structure of key protein involved in cancer, osteoporosis and foot-and-mouth disease finally solved

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/13/2020)... ... March 13, 2020 , ... Acumed LLC today announced ... exclusive distributor of the Louisville-based company’s orthobiologics portfolio. Under the terms of the ... Vivorte’s calcium phosphate-based bone allograft (Trabexus) and calcium phosphate-based biocement (Fortera). Vivorte will ...
(Date:3/9/2020)... ... March 09, 2020 , ... ... a steep growth rate of 64% last year, as enterprises sought to ... from Everest Group. Unfortunately, only 13% of all transformation efforts delivered the ...
(Date:3/5/2020)... ... 2020 , ... Diagenode, a leading global provider of complete ... of global genomics leader BGI Group, today announced a co-marketing agreement for Diagenode’s ... Pacific. , Under the terms of the non-exclusive agreement, the two companies ...
Breaking Biology News(10 mins):
(Date:3/19/2020)... ... March 17, 2020 , ... ... collaboration agreement with pioneering gene circuit company Senti Biosciences, Inc. (Senti) to ... and other solid tumor indications. The collaboration will leverage RoosterBio’s human mesenchymal ...
(Date:3/10/2020)... Tex. (PRWEB) , ... March ... ... a full-service cold chain biopharmaceutical engineering firm, is pleased to announce ... focus is on combination medical device qualification and validation in the biopharmaceutical ...
(Date:3/3/2020)... ... 2020 , ... Ideal Implant Incorporated Founder and CEO, Robert ... the IMCAS Innovation Shark Tank 2020 in Paris, France in January. The international ... science industries that promise to revolutionize medical practices in their fields. , ...
(Date:2/21/2020)... ... February 20, 2020 , ... ... and elegant chemistry. Humans have been increasingly successful in innovating ways to ... rapidly evolving technologies and strategies for modern molecular biology (e.g., gene sequencing, ...
Breaking Biology Technology:
Cached News: