HOME >> BIOLOGY >> NEWS
Structure solved at Scripps shows how one human protein reduces potency of chemotherapy

A team of researchers led by scientists at The Skaggs Institute for Chemical Biology at The Scripps Research Institute have solved the structure of a human protein called AGT that is known to interfere with the action of certain chemotherapy drugs.

AGT repairs damaged DNA inside human cells. Cancer cells can use it to repair DNA that has been damaged in the course of chemotherapythus rendering the chemotherapy ineffective.

The structure of AGT, which is being reported in an upcoming issue of the journal Nature Structural & Molecular Biology, was solved in the laboratory of Scripps Research Professor John Tainer, Ph.D., by Research Associate Douglas Daniels, Ph.D. The fine details of this x-ray structure may help scientists find ways to fight certain cancers, such as brain tumors, which express high levels of AGT making them resistant to chemotherapy.

"This structure provides a solid foundation for the development of better drugs and resistant proteins [intended to improve cancer therapies]," says Tainer.

Cancer, Chemotherapy, and Resistance

Cancer is one of the greatest public health scourges in the United States today. According to the U.S. Centers for Disease Control and Prevention, it is the second leading cause of death. In 2001, the most recent year for which such statistics are available, 553,768 people died of some form of cancer.

For years, one of the best available ways to treat cancer has been through the administration of chemotherapy drugs, such as "alkylating" agents, which inhibit the growth of cancer cells by damaging their DNA.

DNA, the molecule that stores our genetic information, is composed of two intertwining helical strands that bind to each other through base pairing. Each strand is composed of four types of DNA bases (A, G, C, and T) attached to one another through a sugar-phosphate backbone. The other strand in the pair has a complementary sequence of bases.

Alkyl
'"/>

Contact: Jason Bardi
jasonb@scripps.edu
858-784-9254
Scripps Research Institute
7-Jul-2004


Page: 1 2 3 4

Related biology news :

1. Structure solved by Scripps scientists shows one way that body controls gene expression
2. Structure of a Nobel-prize winning molecule: Aquaporin
3. Structure of HIV-neutralizing antibody solved
4. Structure of key breast cancer receptor determined
5. Structure of cog at the hub of metabolism reveals anti-ageing function
6. Structure of pain-modulating enzyme described by scientists at the Scripps Research Institute
7. Structure reveals details of cells cargo-carriers
8. Structure of key receptor unlocked; Related proteins will fall like dominoes
9. New Science Press launches Proteins: From Sequence to Structure
10. Third piece completes deadly puzzle: Structure of anthrax toxin offers clues to treatment
11. Structure of key protein involved in cancer, osteoporosis and foot-and-mouth disease finally solved

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/6/2019)... ... June 05, 2019 , ... MedTech Breakthrough , an ... and medical technology market, announced that it has selected Medacta International’s MySpine® MC ... in the 2019 MedTech Breakthrough Awards program. , Medacta® is ...
(Date:6/4/2019)... (PRWEB) , ... June 04, 2019 , ... ... manufacturing of orthopedic medical devices, today announced Q1-19 revenues of $31M, up 12% ... combined with successful roll-out of strategic investments & operational excellence initiatives worldwide. , ...
(Date:6/4/2019)... ... June 04, 2019 , ... Most preclinical EEG ... seizure risk signals, usually based on variations of amplitude, frequency or spike train ... diagnostic methodology due to the complexity and variability of the signal, and automation ...
Breaking Biology News(10 mins):
(Date:6/6/2019)... CYPRESS, Calif. (PRWEB) , ... June 05, 2019 , ... ... pharmaceutical, biotechnology and medical device industries, announced today that they will be receiving 3 ... in San Diego, CA. WCCT received 2 awards in the categories of overall Quality ...
(Date:5/31/2019)... DURHAM, N.C. (PRWEB) , ... May 30, 2019 ... ... Medicine is the first to demonstrate an efficient delivery system for the sustained ... kidney injuries. The platelet-rich plasma-based gel system was able to deliver CM into ...
(Date:5/14/2019)... ... May 13, 2019 , ... ... testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries’ is ... redesigned website aims to improve LDA’s ability to communicate directly with the marketplace; ...
(Date:5/4/2019)... ... May 03, 2019 , ... Diopsys Inc, the world ... Negative Response vision test, a new full field electroretinography (ffERG) protocol designed ... 6.3 million Americans will have glaucoma, with black Americans having the highest prevalence ...
Breaking Biology Technology:
Cached News: