HOME >> BIOLOGY >> NEWS
Stuck on you: Scientists lay bare secrets of bacterial attachment proteins

An unprecedented picture of how bacteria latch on to human cells has been published by UK, French and US scientists. They have produced a finely detailed model of one of the tools used by some of the nastiest varieties of the stomach bug, Escherichia coli, to stick to and gain entry to host cells.

Led by senior author Dr Stephen Matthews, Reader in Chemical and Structural Biology at Imperial College London, the research is published in the latest issue of the journal Molecular Cell (*See Notes to Eds).

Bacteria need to stick to a host cell, before colonising and attacking it, and causing infection. They do this with the help of proteins on their outer surface called adhesins and invasins. The former attaches itself to the host cell and the latter assists the invasion. Together they define how aggressive or virulent the bacteria are at attacking the host.

Most families of adhesins belong to bacteria that cause a single disease, but the 'Dr' family of Adhesins makes far more trouble: it is responsible for chronic diarrhoeal, intestinal and urinary tract infections, and is similar to some present in strains of Salmonella.

The researchers characterised the way in which the Dr Adhesins help bugs to cause multiple diseases because they use a very common receptor on the host cell membrane as an anchor point to attack. They target a receptor responsible for regulating one of the important human immune responses, known as Decay Acceleration Factor, or DAF.

"Cell adhesion is one of the first contacts between bacteria and host," said Dr Matthews. "Knowing the architecture of the bacteria target allows us to conceive ways to disrupt this adhesion, which may lead to potential therapeutic intervention."

Dr Matthews' team at Imperial used nuclear magnetic resonance (NMR) spectroscopy to yield detailed insights into the structure of the two nanometre-wide Dr Adhesins.

Their work helps to resolve a long-standing debate amo
'"/>


1-Sep-2004


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Scientists discover proteins involved in spread of HIV-1 infection
8. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
9. Scientists reinvent DNA as template to produce organic molecules
10. Scientists visualise cellular handmaiden that restores shape to proteins
11. Scientists identify compounds that mimic calorie restriction

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/29/2019)... ... August 29, 2019 , ... Advancements with Ted Danson ... an upcoming episode, which is scheduled to broadcast 1Q/2020. Check local listings for ... cost-effective robotic surgical solutions for the treatment of patients suffering from spinal disorders. ...
(Date:8/27/2019)... ... ... Shoreline Biome , a microbiome research company that develops tools for ... CEO and Karen Woodward as its VP of Business Development. , These two ... and expand the company’s sales worldwide. , Prior to joining Shoreline Biome, Bill McKenzie ...
(Date:8/27/2019)... Fla. (PRWEB) , ... August 27, 2019 , ... ... in life science and drug development. This episode is scheduled to broadcast 4Q/2019. ... explore Debiopharm, a biopharmaceutical research, development, investment and manufacturing company. The show will ...
Breaking Biology News(10 mins):
(Date:8/27/2019)... (PRWEB) , ... August 27, 2019 , ... ... engineering firm, is pleased to announce it has promoted Consulting Engineer, Robert Battista, ... Battista has added the responsibility of onboarding and mentoring new engineers as well ...
(Date:8/23/2019)... ... ... The EnozoPro® converts ordinary tap water into a sanitizing spray capable of ... including E. Coli, Salmonella, MRSA, Listeria and Legionella. It works as a cleaner, sanitizer ... page at rovingblue.com , ”At Enozo, our mission is to develop solutions to replace ...
(Date:8/15/2019)... , ... August 15, 2019 , ... ... Advisory Board. Mr. Lawrence is a member of the Institute of Food Technologists ... and Health (IFSH) Advisory Board, Joint Institute for Food Safety and Applied Nutrition ...
(Date:8/14/2019)... ... 13, 2019 , ... Chata was founded in ... laboratories. After gaining a few significant clients, Lifecycle purchased the company with the ... of manufacturing processing solutions, including reagents for tissue processing. Chata quickly outgrew the ...
Breaking Biology Technology:
Cached News: