HOME >> BIOLOGY >> NEWS
Stuck on you: Scientists lay bare secrets of bacterial attachment proteins

An unprecedented picture of how bacteria latch on to human cells has been published by UK, French and US scientists. They have produced a finely detailed model of one of the tools used by some of the nastiest varieties of the stomach bug, Escherichia coli, to stick to and gain entry to host cells.

Led by senior author Dr Stephen Matthews, Reader in Chemical and Structural Biology at Imperial College London, the research is published in the latest issue of the journal Molecular Cell (*See Notes to Eds).

Bacteria need to stick to a host cell, before colonising and attacking it, and causing infection. They do this with the help of proteins on their outer surface called adhesins and invasins. The former attaches itself to the host cell and the latter assists the invasion. Together they define how aggressive or virulent the bacteria are at attacking the host.

Most families of adhesins belong to bacteria that cause a single disease, but the 'Dr' family of Adhesins makes far more trouble: it is responsible for chronic diarrhoeal, intestinal and urinary tract infections, and is similar to some present in strains of Salmonella.

The researchers characterised the way in which the Dr Adhesins help bugs to cause multiple diseases because they use a very common receptor on the host cell membrane as an anchor point to attack. They target a receptor responsible for regulating one of the important human immune responses, known as Decay Acceleration Factor, or DAF.

"Cell adhesion is one of the first contacts between bacteria and host," said Dr Matthews. "Knowing the architecture of the bacteria target allows us to conceive ways to disrupt this adhesion, which may lead to potential therapeutic intervention."

Dr Matthews' team at Imperial used nuclear magnetic resonance (NMR) spectroscopy to yield detailed insights into the structure of the two nanometre-wide Dr Adhesins.

Their work helps to resolve a long-standing debate amo
'"/>


1-Sep-2004


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Scientists discover proteins involved in spread of HIV-1 infection
8. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
9. Scientists reinvent DNA as template to produce organic molecules
10. Scientists visualise cellular handmaiden that restores shape to proteins
11. Scientists identify compounds that mimic calorie restriction

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/19/2020)... DIEGO (PRWEB) , ... June ... ... a three-part webinar series, “Automate Your Lab with Software for Data Decisions,” ... Attendees will learn how to integrate and automate cutting-edge scientific instruments and ...
(Date:6/11/2020)... ... June 09, 2020 , ... Superior Controls, Inc. ... automation and IT solutions for the life sciences industry, is pleased to announce the ... working out of the company’s Seabrook, New Hampshire office. In his new role, ...
(Date:6/2/2020)... ... June 02, 2020 , ... ... barcode and RFID labeling software developer and solutions provider, today reported that ... improved labeling accuracy and compliance by 100%, resulting in greater efficiency for ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... July 09, 2020 , ... Sentien Biotechnologies, Inc., a ... of Allen R. Nissenson, M.D., F.A.C.P., as its Chief Medical Officer. Dr. ... lead product, SBI-101. Dr. Nissenson serves as an Emeritus Professor of Medicine ...
(Date:7/1/2020)... GREEN, Ohio (PRWEB) , ... June 29, 2020 ... ... that offers access to competitively procured purchasing contracts to its membership, recently named ... to provide TIPS members with the opportunity to purchase ergonomic seating, cafeteria tables, ...
(Date:6/28/2020)... Conn. (PRWEB) , ... June 25, 2020 , ... ... formed to advance photodynamic therapy for treating cancer, today announced the company has ... York (“Roswell Park”). The agreement provides Lumeda globally exclusive rights to Roswell ...
(Date:6/23/2020)... ... June 22, 2020 , ... Regen Suppliers, the one ... includes buy three, get the fourth unit free with no limit on the ... known as exosomes, have been a game changer for regenerative therapies. The products ...
Breaking Biology Technology:
Cached News: