HOME >> BIOLOGY >> NEWS
Stuck on you: Scientists lay bare secrets of bacterial attachment proteins

An unprecedented picture of how bacteria latch on to human cells has been published by UK, French and US scientists. They have produced a finely detailed model of one of the tools used by some of the nastiest varieties of the stomach bug, Escherichia coli, to stick to and gain entry to host cells.

Led by senior author Dr Stephen Matthews, Reader in Chemical and Structural Biology at Imperial College London, the research is published in the latest issue of the journal Molecular Cell (*See Notes to Eds).

Bacteria need to stick to a host cell, before colonising and attacking it, and causing infection. They do this with the help of proteins on their outer surface called adhesins and invasins. The former attaches itself to the host cell and the latter assists the invasion. Together they define how aggressive or virulent the bacteria are at attacking the host.

Most families of adhesins belong to bacteria that cause a single disease, but the 'Dr' family of Adhesins makes far more trouble: it is responsible for chronic diarrhoeal, intestinal and urinary tract infections, and is similar to some present in strains of Salmonella.

The researchers characterised the way in which the Dr Adhesins help bugs to cause multiple diseases because they use a very common receptor on the host cell membrane as an anchor point to attack. They target a receptor responsible for regulating one of the important human immune responses, known as Decay Acceleration Factor, or DAF.

"Cell adhesion is one of the first contacts between bacteria and host," said Dr Matthews. "Knowing the architecture of the bacteria target allows us to conceive ways to disrupt this adhesion, which may lead to potential therapeutic intervention."

Dr Matthews' team at Imperial used nuclear magnetic resonance (NMR) spectroscopy to yield detailed insights into the structure of the two nanometre-wide Dr Adhesins.

Their work helps to resolve a long-standing debate amo
'"/>


1-Sep-2004


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Scientists discover proteins involved in spread of HIV-1 infection
8. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
9. Scientists reinvent DNA as template to produce organic molecules
10. Scientists visualise cellular handmaiden that restores shape to proteins
11. Scientists identify compounds that mimic calorie restriction

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/26/2019)... ... 25, 2019 , ... The team at Cieplak Dental Excellence ... myofunctional disorders (OMDs) are abnormal movement patterns of the face and mouth that ... from difficulty swallowing and limited tongue movement to an overbite. Participation in this ...
(Date:10/22/2019)... ... 2019 , ... Greenberg Traurig, LLP’s global Life Sciences & ... the Life Sciences Sector,” with German biotech strategy consulting firm, Catenion. The seminar will ... Tokyo office . , Speakers from Greenberg Traurig and Catenion will discuss best ...
(Date:10/17/2019)... HOUSTON, Texas (PRWEB) , ... October 15, 2019 ... ... engineering firm, is pleased to announce it made its first appearance on the ... two-year revenue growth of 56 percent. , With corporate headquarters in Houston, ...
Breaking Biology News(10 mins):
(Date:10/30/2019)... ... October 30, 2019 , ... Western ... many roles innovation and technology play in educating the next generation of health ... learning opportunities and presentations by WesternU administrators and representatives of companies working with ...
(Date:10/29/2019)... ... October 29, 2019 , ... Modality Solutions, a ... cold chain validation workshop at the Biomanufacturing World Summit (BMWS19) Conference, November 11-12, ... The Biomanufacturing World Summit brings together pharmaceutical executives, cutting-edge technology providers, ...
(Date:10/26/2019)... ... 2019 , ... Sparks Marketing Group, Inc. (Sparks) ... boutique healthcare-specific marketing firm, to strengthen the agency’s growing focus on the healthcare ... clients in pharma, bio-therapeutics, medical device and healthcare technologies currently account for a ...
(Date:10/22/2019)... (PRWEB) , ... October 22, 2019 , ... Catalent, a ... Supply Services and Drug Product Technologies Integration, will participate in a panel session titled ... (HPCLC), to be held at the Gwen Hotel, Chicago, on Oct. 28-30, 2019. , ...
Breaking Biology Technology:
Cached News: