HOME >> BIOLOGY >> NEWS
Studies offer new insight into HIV vaccine development

MADISON-Mutations that allow AIDS viruses to escape detection by the immune system may also hinder the viruses' ability to grow after transmission to new hosts, scientists at the University of Wisconsin-Madison announced this week in the journal Nature Medicine.

The discovery may help researchers design vaccines that exploit the notorious mutability of HIV by training the immune system to attack the virus where it's most vulnerable. The work appears alongside a study of HIV-infected people performed by scientists at Harvard Medical School and Oxford University. The Wisconsin study's lead author, Thomas Friedrich, is a doctoral student working under the direction of David Watkins, professor of pathology at UW-Madison and senior scientist at the Wisconsin National Primate Research Center.

Watkins' team produced an "escaped" AIDS virus that mimicked events that occur in HIV infection when the virus mutates to become unrecognizable to killer cells known as cytotoxic T-lymphocytes, or CTL. The researchers found that the mutant virus did not grow as well as the original strain. The mutations, while allowing the virus to escape immune recognition, had also weakened the virus. To model the transmission of escaped viruses between people, the team inoculated monkeys with the mutant virus strain. They discovered that most of the escape mutations were lost as the virus grew in the monkeys, often restoring original sequences that killer cells could recognize.

Some scientists have theorized that HIV could adapt to the human immune system as the AIDS epidemic develops, becoming less and less recognizable. Watkins said that his group's findings should help allay these fears.

The UW-Madison group has been studying immunity to AIDS viruses since the early 1990s. Most recently, the researchers have been studying the ways in which viruses mutate to "escape" recognition by the body's killer cells. Killer cells are white blood cells that perform
'"/>

Contact: David Watkins
608-265-3380
University of Wisconsin-Madison
16-Feb-2004


Page: 1 2

Related biology news :

1. Monkey business: Studies show tiny callimicos have unusual characteristics
2. Studies show success of Mectizan partnerships
3. Studies suggest brain injury results from developmental exposure to alcohol, anesthesia, and lead
4. Studies show preventive value of food supplements
5. Studies probe rapid evolution of Chinese tallow trees
6. Studies of rare blood syndrome yield novel route to cancer
7. Studies dispute ultraviolet effect on amphibian population declines
8. Studies of spiders silk reveal unusual strength
9. Studies of genes in mice and common worm may accelerate research on blood diseases, cancers
10. Studies offer data on potential impact of Reminyl on caregiver burden in Alzheimers disease
11. Studies: Floyd, other major hurricanes of 99 caused significant changes in nations largest lagoonal estuary

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... LONDON , April 4, 2017 KEY ... is anticipated to expand at a CAGR of 25.76% ... neurodegenerative diseases is the primary factor for the growth ... full report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The ... of product, technology, application, and geography. The stem cell ...
(Date:3/30/2017)... Trends, opportunities and forecast in this market ... (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, vein ... use industry (government and law enforcement, commercial and retail, ... others), and by region ( North America ... Pacific , and the Rest of the World) ...
(Date:3/24/2017)... Research and Markets has announced the addition of the "Global ... to 2025" report to their offering. ... The Global Biometric Vehicle Access System Market ... the next decade to reach approximately $1,580 million by 2025. ... for all the given segments on global as well as regional ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights that give it exclusive ... a technology developed in collaboration with Children’s Hospital Los Angeles (CHLA). ...
(Date:10/10/2017)... 10, 2017 SomaGenics announced the receipt of ... develop RealSeq®-SC (Single Cell), expected to be the first ... (including microRNAs) from single cells using NGS methods. The ... to accelerate development of approaches to analyze the heterogeneity ... "New techniques for measuring levels of mRNAs in individual ...
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer television series ... 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , With global population ... challenge of how to continue to feed a growing nation. At the same time, ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... instruments and applications consulting for microscopy and surface analysis, Nanoscience Instruments is ... Nanoscience Analytical offers a broad range of contract analysis services for advanced ...
Breaking Biology Technology:
Cached News: