The first measurable tumors were observed in both groups on day 15 after injection. However, the control group experienced 13 measurable tumors whereas the [6]-gingerol group reported only four measurable tumors. All mice in the control group developed tumors by day 28, as compared to day 38 for the [6]-gingerol group. Results showed that mice fed [6]-gingerol survived significantly longer than those receiving the control, implying that the tumors grew much slower in the first group. By day 49, all control mice contained tumors at least one cubic centimeter in size. By comparison, 11 mice in the [6]-gingerol group still had not developed tumors of that size.

Preliminary results also suggest that many of the tumors in the control group were invasive into the abdominal cavity, whereas the [6]-gingerol group appeared to be less invasive.

"These results strongly suggest that our hypothesis on the value of ginger is correct," said Dr. Bode, lead author of the study. "As we continue to study the spice in other tumor areas, we hope it will translate into significant anti-cancer properties for humans."

Chinese Medicinal Herb, "Scutellaria Barbata," Modulates Apoptosis in TRAMP-C1 Prostate Cancer Cells and Tumor Development in TRAMP Mice (Abstract 1253)

The Chinese herb Scutellaria barbata (SB), a species related to mint of the Labiate family, has been used in traditional Chinese medicine to treat several illnesses, including cancers of the liver, lung and rectum. In this study, presented by researchers from Union College in Nebraska, SB was found to slow the progression of prostate tumors in mice, suggesting potential chemopreventive effects. Prostate cancer is the second leading cause of cancer deaths among American men. Transgenic adenocarcinoma of the mouse prostate (TRAMP) mimics tumor progression in human prostate cancer, and thus provides a relevant pre-clinical model for determining treatments and prevention techniques.
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Contact: Aimee Frank
amf@spectrumscience.com
202-955-6222
American Association for Cancer Research
28-Oct-2003

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