Study: breath test effective in showing patients who should get less cancer drug

Battling cancer is traumatic enough without worrying about whether chemotherapy will prove toxic, but that's the added risk facing a minority of cancer patients.

Standard doses of chemotherapy -- often effective in treating various solid tumors -- sometimes kill people whose livers cannot clear the drug at the normal rate. Doctors can't tell beforehand which patients might have trouble with the treatment.

Now, a new study shows a relatively simple technique pioneered by a University of North Carolina at Chapel Hill, physician can distinguish between patients who metabolize one anti-cancer drug normally and those who need to receive lower doses for safety. Researchers say the approach might work for other chemotherapy agents and perhaps other non-cancer drug treatments as well.

"When you take a drug like aspirin or Tylenol, the reason you need to take it again in four to six hours is that your body has chewed it up and gotten rid of it through a certain chemical pathway in the liver," said Dr. Paul B. Watkins, professor of medicine and director of the Verne S. Caviness General Clinical Research Center at the UNC-CH School of Medicine. "Because of diet, genetics and other factors, some people just metabolize drugs a lot more slowly. As a result, the recommended dose of many chemotherapies will predictably make about 10 percent of patients very ill, and 1 or 2 percent of patients may die as a direct result of the treatment."

Conversely, patients whose livers clear a given chemotherapy rapidly may not get a dose strong enough to be effective against their cancer, he said.

A report on the new study appears in the April issue of Clinical Cancer Research, a medical journal that has just been released. Besides Watkins, authors include Drs. JoAnn Hirth, Myla Strawerman, Anne Schott and Laurence Baker of the University of Michigan.

Investigators took blood samples from 21 cancer patients several times over 24 hours to determine how fast t

Contact: David Williamson
University of North Carolina at Chapel Hill

Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study: A little help from friends makes wounds heal faster
3. Study: Mothers turn fearless when peptide level drops
4. Study: Artificial sweetener may disrupt bodys ability to count calories
5. Study: Mimicking viruses may provide new way to defeat them
6. Study: Stroke victims may retain continuous motion ability
7. Study: Adults maintain significant improvement in ADHD with long-term use of amphetamine
8. Study: Prenatal screening in Haiti region cut syphilis by 75 percent
9. Study: Isoflavone-enriched soy proteins fail to increase bone mineral density in young women
10. Study: Genome-wide scanning unravels complex birth defect
11. Study: Higher energy intake, obesity affects all age groups, not just youths

Post Your Comments:

(Date:5/16/2017)... 2017  Veratad Technologies, LLC ( www.veratad.com ), an ... identity verification solutions, announced today they will participate as ... 15 thru May 17, 2017, in Washington ... Center. Identity impacts the lives of ... quickly evolving digital world, defining identity is critical to ...
(Date:4/18/2017)... April 18, 2017  Socionext Inc., a global expert in SoC-based ... edge server, the M820, which features the company,s hybrid codec technology. ... by Tera Probe, Inc., will be showcased during the upcoming Medtec ... show at the Las Vegas Convention Center ... Click here ...
(Date:4/11/2017)... Research and Markets has announced the addition of the ... ... grow at a CAGR of 30.37% during the period 2017-2021. ... prepared based on an in-depth market analysis with inputs from industry ... over the coming years. The report also includes a discussion of ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 2017 , ... Personal eye wash is a basic first aid supply for any work environment, ... eye do you rinse first if a dangerous substance enters both eyes? It’s one less ... with its unique dual eye piece. , “Whether its dirt and debris, or an acid ...
(Date:10/11/2017)... -- VMS BioMarketing, a leading provider of patient support solutions, has ... (CNE) network, which will launch this week. The VMS CNEs ... professionals to enhance the patient care experience by delivering peer-to-peer ... care professionals to help women who have been diagnosed and ... ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... maternal age to IVF success. , After comparing the results from the fresh ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights ... (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital ...
Breaking Biology Technology:
Cached News: