HOME >> BIOLOGY >> NEWS
Study: nitric oxide-releasing materials might reduce medical implant infections

postdoctoral fellow Dr. Ta.-Yung Chen also are authors.

The team created compounds known as aminosilane-based sol-gels as thin films on glass slides. They then converted the amino acid groups to nitric oxide donors by exposing the films to high pressures of nitric oxide gas.

Later measurements showed that the compounds released nitric oxide gas continuously for days, Schoenfisch said. Varying the amount and type of aminosilane in the sol-gel could change the rate and amount of nitric oxide release.

To test whether the materials prevented bacterial adhesion, the team then exposed both nitric oxide-releasing and untreated control slides to solutions of Pseudomonas aeruginosa, a common infection-causing bacterium. Bacterial adhesion was as much as 70 percent lower on the nitric oxide-releasing slides.

Preventing bacterial adhesion and biofilm formation is vital for reducing infection since biofilms are extremely resistant to immune system defenses once they have formed on an implant, the scientist said. Such films can cause chronic illness with severe and universal symptoms such as headache, nausea, vomiting, abdominal cramps, sore throat, sore eyes and fever, making diagnosis difficult.

Besides its anti-bacterial adhesion properties, nitric oxide plays a role in several other important physiological processes including blood pressure regulation, nerve transmission, platelet adhesion and tumor cell growth. The impotence drug Viagra relies on nitric oxide action to work, he said.

People in the biomaterial research community have been struggling for years to control bacterial adhesion, Schoenfisch said. Despite the many recent advances in medicine, implant-related infection remains a most serious problem. Polymeric nitric oxide release represents a unique strategy, particularly since nitric oxide has a short half-life in blood -- just a few seconds -- and thus would only have an effect on areas near the implant site where
'"/>

Contact: David Williamson
david_williamson@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
7-Sep-2001


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study: A little help from friends makes wounds heal faster
3. Study: Mothers turn fearless when peptide level drops
4. Study: Artificial sweetener may disrupt bodys ability to count calories
5. Study: Mimicking viruses may provide new way to defeat them
6. Study: Stroke victims may retain continuous motion ability
7. Study: Adults maintain significant improvement in ADHD with long-term use of amphetamine
8. Study: Prenatal screening in Haiti region cut syphilis by 75 percent
9. Study: Isoflavone-enriched soy proteins fail to increase bone mineral density in young women
10. Study: Genome-wide scanning unravels complex birth defect
11. Study: Higher energy intake, obesity affects all age groups, not just youths

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/15/2016)... 2016 "Increase in mobile transactions is driving ... biometrics market is expected to grow from USD 4.03 ... at a CAGR of 29.3% between 2016 and 2022. ... growing demand for smart devices, government initiatives, and increasing ... component is expected to grow at a high rate ...
(Date:12/8/2016)... , Dec. 8, 2016  Singulex, Inc., the leader ... technology, entered into a license and supply agreement with ... The agreement provides Singulex access to Thermo Scientific BRAHMS ... is used to diagnose systemic bacterial infection ... to aid in assessing the risk of ...
(Date:12/7/2016)... 2016   Avanade is helping Williams Martini ... in history, exploit biometric data in order to critically ... the competitive edge against their rivals after their impressive, ... Avanade has worked with Williams during the 2016 season ... (heart rate, breathing rate, temperature and peak acceleration) for ...
Breaking Biology News(10 mins):
(Date:1/17/2017)... Point, IA (PRWEB) , ... January 17, 2017 ... ... from China for Balance™ GT soybeans. The new Balance™ GT Soybean Performance System ... to glyphosate and isoxaflutole, the active ingredient in the new Balance® Bean herbicide. ...
(Date:1/17/2017)... -- Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH) today ... earnings conference call will be broadcast live over the ... Eastern Time.  A news release detailing the quarterly and ... Eastern Time the morning of the conference call. ... Zimmer Biomet,s Investor Relations website at http://investor.zimmerbiomet.com . ...
(Date:1/17/2017)... , Jan. 17, 2017  Only nine percent ... patients over profits, while only 16 percent believe health ... released today. Meanwhile, 36 percent of U.S. adults believe ... patients over profits, compared to hospitals (23%). ... maelstrom," said Wendy Salomon , vice president of ...
(Date:1/17/2017)... Boston, MA (PRWEB) , ... January 17, 2017 ... ... of the completely re-engineered Drug Safety Technology Consortium™ (SafeTEC™), $3 million in investment ... be validating these new tools and assays, and their applicability in drug safety ...
Breaking Biology Technology:
Cached News: