Study Finds Choline Deficiency Harms Memory Center In Mammals' Brains

CHAPEL HILL - Have you noticed your memory isn't what it used to be? Perhaps you can blame it on your mother's diet.

Researchers at the University of North Carolina at Chapel Hill report for the first time in this month's issue of Developmental Brain Research that diet during a critical period of pregnancy can change the birth and death of cells in the developing memory centers of babies' brains.

Dietary deficiency of choline, an essential nutrient, significantly changed the structure of those memory centers - the hippocampus and septum -- by reducing cell division, changing cell migration and by increasing the number of cells that die prematurely. Although the research took place on rats, something similar could happen in human babies, researchers say.

"We already knew that pregnant rats offered extra choline during days 12 to 18 of their 21-day pregnancies had babies that performed much better on memory tests for the rest of their lives," said Dr. Steven Zeisel, chair of nutrition at the UNC-CH schools of public health and medicine. "Even very old rats performed better on such tests as running through a maze."

Because they had no explanation for the improved performance, the UNC-CH group examined brains of unborn rat pups to learn whether they could detect physical differences between those whose mothers received extra choline and those whose mothers did not receive enough.

"For the first time we have shown that the very structure of brain is influenced by what the mothers eat during pregnancy and that this specific nutrient choline appears to be critical," Zeisel said.

Other report authors include Dr. Craig D. Albright, research assistant professor of nutrition, graduate students Amy Y. Tsai and Claudia B. Friedrich and technician Mei-Heng Mar.

The findings are of special interest because the National Academy of Sciences' Institute of Medicine last fall for the first time recommended choline as an essential nutrient for h

Contact: David Williamson
University of North Carolina at Chapel Hill

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