Study Finds Evidence Linking The Brain's Cognitive Control Regions With Stress Contr...( Other rats were exposed to chroni...)

Other rats were exposed to chronic intermittent stress for two weeks. The stress areas in the brains of the rats showed pronounced increases in GAD65 expression, indicating that following chronic stress, the animal was attempting to increase the pool of enzyme to attempt to compensate for continual stress exposure.

"It's only in the stress responsive hypothalamic regions of the brain that we're seeing these changes, indicating that stress is activating inhibitory systems," Herman said.

"These studies indicate that signals from higher regions of brain essentially communicate through more primitive regions to influence stress responses, essentially asking neurons controlling the ongoing health status of the animal whether it's OK to mount a stress response. Our results suggest these primitive structures are likely to be a focus of abnormalities seen in stress-related diseases of the brain."

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Contact: Kim Cumbie
krcumb0@pop.uky.edu
(606) 323-6363
University of Kentucky Medical Center
19-Aug-1998

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