HOME >> BIOLOGY >> NEWS
Study Finds Gene Is Associated With Higher Risk Of One Kind of Stroke Among African-Americans

ORLANDO, Fla. -- The variant form of a gene that has been implicated in the most common form of Alzheimer's disease also may predispose blacks to intracerebral hemorrhages (ICH), a severe form of stroke, researchers from Duke University Medical Center reported Friday.

The researchers also found that overall, these strokes occurred in African Americans at a much earlier age -- on average, more than seven years earlier.

Duke neurologist Dr. Mark J. Alberts prepared the results of the study for presentation Friday at the American Heart Association's 23rd International Joint Conference on Cerebral Circulation and Stroke.

The gene, located on chromosome 19, is the blueprint for the production of apolipoprotein-E (apo-E), a protein that is responsible for transport and disposal of cholesterol within the central nervous system. The researchers focused on one of the gene's three known variants, or alleles -- the one called e4.

They found that in the study, blacks with a single e4 allele, inherited from one parent, were twice as likely to have ICH when compared to control groups; they were more than eight times as likely to have these strokes if they had two alleles (one from each parent).

"Past studies have shown that African Americans tend to have a higher occurrence of ICH than Caucasians, and that they tend to die at a higher rate," Alberts said. While not nearly as common as strokes caused by blockages in vessels in the brain (85 percent of all strokes), ICHs are much more severe, with a mortality rate approaching 50 percent, Alberts said.

"This study demonstrates that the e4 allele may be a strong predictor of which African Americans are most likely to suffer from intracerebral bleeds," Alberts said.

The Duke team conducted genetic analysis on 124 patients (63 males and 61 females between the ages of 30 and 88) who suffered from ICH due to hypertension, amyloid angiopathy (b
'"/>

Contact: Richard Merritt
Merri006@mc.duke.edu
919-684-4148
Duke University Medical Center
6-Feb-1998


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2020)... ... August 21, 2020 , ... The August edition ... and is now available on the company’s global website. Crystallography Times—an electronic newsletter ... presenting current news and crystallographic research. , The latest issue of Crystallography ...
(Date:8/12/2020)... ... August 11, 2020 , ... ... in Princeton, NJ, have entered into license agreements with Housey Pharma’s HMI subsidiary ... Both Roche and J&J have annual Research and Development spending in excess of ...
(Date:8/3/2020)... ... August 03, 2020 , ... ... a new partnership with medical equipment manufacturer, Spectrum Solutions, to provide COVID-19 saliva ... strengthen their laboratory supply chain for more than 10 years. Early in the ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... July 16, 2020 , ... Medial ... early detection and prevention of high-burden diseases, and Centric Consulting, a business and ... organizations to utilize existing data in order to identify and prioritize patients for ...
(Date:7/10/2020)... ... July 09, 2020 , ... In most research using the ... pigment formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging. Over ... been using the zebrafish model to investigate the causes of leukaemia and its ...
(Date:7/1/2020)... ... June 29, 2020 , ... MedShift ... 40% in 2020, despite many obstacles created as a result of COVID-19. As ... for its partnered medical practices and medical manufacturers by expanding access to device ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... develop a vaccine or drug treatment. In an effort to better understand the ... released the world’s largest imaging dataset portraying therapeutic compound effects from over 1,600 ...
Breaking Biology Technology:
Cached News: