HOME >> BIOLOGY >> NEWS
Study Finds Protein Clues To Early Embryo Development

CHAPEL HILL - In a study of life's beginnings, scientists at the University of North Carolina at Chapel Hill have moved a step closer to unraveling the biochemical mystery of embryogenesis, the process by which an egg cell transforms into an embryo.

At the heart of this new research is a pair of cellular proteins - SLBP1 and SLBP2 - which were identified in frog oocytes (immature egg cells) by researchers headed by Dr. William F. Marzluff, professor of biochemistry and biophysics at UNC-CH School of Medicine. In a report of the findings published in January's Molecular and Cellular Biology, Marzluff and his study colleagues suggest that the proteins act as separate "on" or "off" biochemical switches that trigger synthesis of histone proteins crucial to normal cell functioning during embryogenesis and throughout the organism's life. About half of the nucleoprotein complex known as DNA are histone proteins.

Although the new study looked at frog oocytes - largely because of their accessibility in large quantities - proteins structurally similar to SLBP1 have been identified in other organisms, including worms, flies, and mice, according to Dr. Thomas C. Ingledue, a postdoctoral fellow in Marzluff's laboratory. Ingledue is a lead co-author of the report along with Dr. Zeng-Feng Wang, formerly of UNC-CH and now with the Carnegie Institute of Embryology. "The new findings are already focusing our studies on other model systems, including mammalian," Ingledue says.

Studies have established that all genes are inactive - turned off - during early embryogenesis. In frog cells, they remain off until the embryo has gone through 12 rounds of division. "And if you don't activate genes during development but you have a need for a large amount of proteins to be used during development, then you better have those proteins stored. Or you better be ready to translate, or activate, stored RNA to make those proteins," Ingledue explains. "That's what the crux of our work
'"/>

Contact: Lynn Wooten
lwooten.est1@mail.unch.unc.edu
919-966-6046
University of North Carolina School of Medicine
28-Jan-1999


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology:
Cached News: