HOME >> BIOLOGY >> NEWS
Study Finds Protein Clues To Early Embryo Development

CHAPEL HILL - In a study of life's beginnings, scientists at the University of North Carolina at Chapel Hill have moved a step closer to unraveling the biochemical mystery of embryogenesis, the process by which an egg cell transforms into an embryo.

At the heart of this new research is a pair of cellular proteins - SLBP1 and SLBP2 - which were identified in frog oocytes (immature egg cells) by researchers headed by Dr. William F. Marzluff, professor of biochemistry and biophysics at UNC-CH School of Medicine. In a report of the findings published in January's Molecular and Cellular Biology, Marzluff and his study colleagues suggest that the proteins act as separate "on" or "off" biochemical switches that trigger synthesis of histone proteins crucial to normal cell functioning during embryogenesis and throughout the organism's life. About half of the nucleoprotein complex known as DNA are histone proteins.

Although the new study looked at frog oocytes - largely because of their accessibility in large quantities - proteins structurally similar to SLBP1 have been identified in other organisms, including worms, flies, and mice, according to Dr. Thomas C. Ingledue, a postdoctoral fellow in Marzluff's laboratory. Ingledue is a lead co-author of the report along with Dr. Zeng-Feng Wang, formerly of UNC-CH and now with the Carnegie Institute of Embryology. "The new findings are already focusing our studies on other model systems, including mammalian," Ingledue says.

Studies have established that all genes are inactive - turned off - during early embryogenesis. In frog cells, they remain off until the embryo has gone through 12 rounds of division. "And if you don't activate genes during development but you have a need for a large amount of proteins to be used during development, then you better have those proteins stored. Or you better be ready to translate, or activate, stored RNA to make those proteins," Ingledue explains. "That's what the crux of our work
'"/>

Contact: Lynn Wooten
lwooten.est1@mail.unch.unc.edu
919-966-6046
University of North Carolina School of Medicine
28-Jan-1999


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Study Finds Protein Clues Early Embryo Development

(Date:7/31/2014)... genes to the earliest common ancestor of butterflies ... an extensive "Tree of Lepidoptera" in the first ... , Among the study,s more surprising findings: Butterflies ... to large ones, which completely changes scientists, understanding ... that some insects once classified as moths are ...
(Date:7/31/2014)... It has long been known that biomass burning ... savannah as a ritual , slash-and-burn agriculture and ... public health. , But until the release of ... Environmental Engineering Professor Mark Z. Jacobson, the degree ... , Jacobson,s research, detailed in a paper published ...
(Date:7/31/2014)... (HPV-023; NCT00518336) shows the sustained efficacy, immunogenicity ... (HPV) vaccine Cervarix. Women vaccinated with the ... than nine years, and vaccine efficacy (VE) ... the longest follow-up report for a licensed ... the full paper. , HPV and ...
Breaking Biology News(10 mins):UF study advances 'DNA revolution,' tells butterflies' evolutionary history 2UF study advances 'DNA revolution,' tells butterflies' evolutionary history 3Stanford professor finds that wildfires and other burns play bigger role in climate change 2Stanford professor finds that wildfires and other burns play bigger role in climate change 3Stanford professor finds that wildfires and other burns play bigger role in climate change 4Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine 2Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine 3
(Date:7/31/2014)... 31, 2014 Although RNA-Sequencing is ... first transcriptome-wide analyses appearing around 2008, RNA-Sequencing has ... RNA measurement. In the last several years, assays ... work with smaller input amounts, process degraded RNA, ... samples). On the bioinformatics side, there have been ...
(Date:7/31/2014)... 2014   BioLife Solutions , Inc. (NASDAQ: ... of proprietary clinical grade hypothermic storage and ... shipping products for cells and tissues, today announced ... will be released on Thursday, August 7, 2014, and ... live webcast at 4:30 p.m. ET that afternoon. Management ...
(Date:7/31/2014)... July 31, 2014 The Kidney Cancer Association ... its monthly news magazine, Kidney Cancer News. , Bill ... on a website maintained by an international news organization. When ... increase in viewers.” , This month’s program highlights news of ... analyzed in a recent study. Kidney Cancer News also ...
(Date:7/31/2014)... AZ (PRWEB) July 31, 2014 Sales ... availability of its online sales training course – ... improve their sales performance. , Drawn from proven sales ... 500 companies, Mastering the Complex Sale online sales training ... to anyone who has face-to-face contact with customers, like ...
Breaking Biology Technology:The Evolution of RNA-Sequencing, Upcoming Live Webinar August 22 hosted by Xtalks 2BioLife Solutions to Report Financial Results for Second Quarter 2014 and Provide Business Update on August 7, 2014 2Sales Horizons Offers Mastering the Complex Sale - a Comprehensive, Online Sales Skills Training Course 2Sales Horizons Offers Mastering the Complex Sale - a Comprehensive, Online Sales Skills Training Course 3
Cached News: