HOME >> BIOLOGY >> NEWS
Study Of Protein Reveals Two Different Prostate Cancers;One More Deadly Also Shows That Benign Prostate Hyperplasia Not A Precursor To Prostate Cancer

New York, N.Y., September 1, 1998 -- In a study of the protein p27, researchers at Memorial Sloan-Kettering Cancer Center have confirmed the existence of at least two different types of prostate cancer. One is a more aggressive form of the disease with a higher rate of recurrence and poorer long term survival. Researchers believe that this information can help in determining the patient's prognosis which may affect treatment selection.

Researchers also discovered that p27 plays a distinct role in Benign Prostate Hyperplasia (BPH) which was found to be genetically different from prostate cancer. This supports the thesis that it is not a precursor to the development of prostate cancer.

The study, published in the September Journal of the National Cancer Institute, involved the examination of the levels of p27 protein in one hundred and thirty tissue samples of patients with prostate cancer as well as samples from normal men and patients with BPH.

The p27 protein, first discovered by study co-authors Dr. Joan Massagu, chairman of the Cell Biology Program at Memorial Sloan-Kettering and Dr. Andrew Koff of the Molecular Biology Program, is one of the proteins generically called a cell cycle inhibitor. It is a potential tumor suppressor. Normal prostate tissue has abundant amounts of both p27 protein and its messenger RNA (p27KIP1 mRNA), the intermediary between the gene and the protein. However, both messenger and protein are undetectable in patients with BPH. In contrast, patients with prostate cancer have abundant p27KIP1mRNA but p27 protein levels were variable - high in some cases or very low to undetectable in others. Investigators found that prostate cancers with the lower levels of p27 were more aggressive.

"Our study reinforces previous research that suggests that prostate cancer can develop along two different pathways, one involving the loss of p27 and the other using processes that circumvent the growth-suppressive effects of p27," sa
'"/>

Contact: Joanne Nicholas
nicholaj@mskcc.org
(212) 639-3573
Memorial Sloan-Kettering Cancer Center
1-Sep-1998


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/4/2020)... , ... July 03, 2020 , ... ... to earn outstanding recognition and multiple awards for not only the products and ... portfolio, SoME® Skincare and Vivace® Microneedle RF. All the brands built by ABM ...
(Date:7/2/2020)... ... July 02, 2020 , ... ... (MBS) has announced a publication detailing the use of its revolutionary NEXTGENPCR ... chain reaction (RT-PCR) in 16 minutes. The article, titled "Ultra-fast one-step RT-PCR ...
(Date:7/1/2020)... , ... July 01, 2020 , ... ... awareness and solutions for glioblastoma—the most common and aggressive adult brain cancer—announced today ... JD, PhD. Senior Fellows are charged with supporting the organization’s initiatives and overall ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 30, 2020 , ... ... software for the life sciences industry, today announced the release of its ... specifically for Medical Science Liaisons (MSLs) and other field medical professionals. ...
(Date:7/18/2020)... ... July 17, 2020 , ... ... firm for the life sciences and food industries, is pleased to announce that ... Clinical Research – Business Development. , Charles is an accomplished and results-driven sales ...
(Date:7/7/2020)... DIEGO (PRWEB) , ... July 06, 2020 , ... R3 ... new program featuring up to 200 million stem cells. Depending on the patient's condition, ... seniors in the US will die having some form of Alzheimers dementia, and the ...
(Date:6/28/2020)... NIGUEL, Calif. (PRWEB) , ... June 25, 2020 , ... ... announced the launch of Safe Space™ for businesses of all types to ensure cleanliness, ... 3D LiDAR. , A Safe Space™ enabled business will provide a health ...
Breaking Biology Technology:
Cached News: