HOME >> BIOLOGY >> NEWS
Study Shows First Significant Genetic Evidence For Schizophrenia Susceptibility

A 15-year study in more than 100 families and 1,000 subjects provides the first reliable evidence of genetic susceptibility to schizophrenia, within a stretch of DNA on human chromosome 13. The association of DNA with the susceptibility to the disease, reported by a Johns Hopkins-led international team, is the first such linkage to meet stringent statistical standards.

"Finding an actual gene for schizophrenia susceptibility will be like finding a particular house in a large city," says genetic epidemiologist Ann Pulver, Sc.D., who led the study; "But we've found the city. It's a first step, and an exceedingly important one."

The study, reported in this month's Nature Genetics, also suggests that different genes may be responsible for the disease in different families.

Most experts agree schizophrenia is a condition influenced by both genes and environment. In studies of identical twins, for example, where only one twin develops schizophrenia, the other twin has a 46 percent chance of having the disorder. That's higher than the 1 percent rate for the general population but not the near-100 percent expected if genes are the only cause. "It's not the case that you have the gene, you have the disease,'" says Pulver. "The genetic effect is one of susceptibility to schizophrenia."

Unlike such inherited disorders as sickle cell anemia, which stems from mutation in a single gene, susceptibility to schizophrenia involves more than one gene, Pulver says, as well as environmental factors.

In the new study, the researchers carefully evaluated and took blood samples from 54 patients diagnosed with either schizophrenia or with schizoaffective disorder, a type of schizophrenia with elements of depression, mania or both. Researchers also evaluated and took samples from patients' extended families.

They extracted blood cell DNA and scanned it with molecular probes, looking for particular sequence
'"/>

Contact: Marjorie Centofanti
mcentofanti@jhmi.edu
(410) 955-8725
Johns Hopkins Medical Institutions
1-Sep-1998


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/29/2018)... ... August 28, 2018 , ... Johanna Dwyer, founder and ... women of excellence in the field of intellectual property, and named Daniela Sanchez ... in IP Award aims to encourage and support women in their pursuit of ...
(Date:8/29/2018)... ... August 29, 2018 , ... Ovation ... abnormalities using morphological assessment through artificial intelligence , A recent, international collaborative ... suggests that artificial intelligence (AI) models, applied to 2D images of ...
(Date:8/26/2018)... ... August 24, 2018 , ... ... tool in clinical diagnostic laboratories. However, this technology introduces many well-described challenges ... London, which leads the South London NHS Genomic Medicine Centre. The Viapath ...
Breaking Biology News(10 mins):
(Date:9/12/2018)... (PRWEB) , ... September 11, 2018 , ... ... proud to add flat sheet Forward Osmosis (FO) membranes from Fluid Technology Solutions ... membranes manufactured by FTS H2O are constructed from cellulose triacetate (CTA) material. The ...
(Date:9/7/2018)... SANTA CLARA, Calif. (PRWEB) , ... September 05, 2018 , ... ... sponsored by Park Systems will be held on Sept. 19, 2018. With a panel ... trends on SPM, this exciting event will reveal industry insights from experts in the ...
(Date:9/7/2018)... ... 06, 2018 , ... Cognition® Corporation , a software ... its upcoming user conference. , This year NAVIGATE2018 —the annual conference—will ... approaches to regulatory compliance and quality management. , “We’ve got a stellar lineup ...
(Date:9/7/2018)... ... 06, 2018 , ... Akadeum Life Sciences today announced it has appointed George ... and leader of numerous biotech companies. , He most recently served as president ... Thompson Street Capital in St. Louis, MO. Prior to ISTO, he was a ...
Breaking Biology Technology:
Cached News: