HOME >> BIOLOGY >> NEWS
Study backs theory that accumulating mutations of 'quiet' genes foster aging

CHAMPAIGN, Ill. -- A theory that suggests the aging process might be safely slowed by targeting genes that are quiet early but threaten damage later in life has gotten a boost from new findings from the University of Illinois at Urbana-Champaign.

The researchers don't promote such tinkering in their paper, which appears online this week in advance of publication by the Proceedings of the National Academy of Sciences. Rather they detail their tests, based on models of mathematical prediction, of the two leading evolutionary theories of aging on the reproductive success of 100 different genotypes of fruit flies (Drosophila melanogaster) across various age groups.

The results suggest that more needs to be learned about which genes do what and when in the aging process so that artificial manipulation does not cause evolutionary damage in future generations, said Kimberly A. Hughes, an animal biologist in the Program in Ecology and Evolutionary Biology at Illinois.

The study provides the strongest support yet for the theory of mutation accumulation (MA), Hughes said. The theory, which has been difficult for scientists to test, proposes that aging is the result of an accumulation of mutations of genes that are kept in check by reproductive-oriented selection processes early in life and only are active later on.

Examples are genes associated with Huntington's disease and forms of cancer that strike late in life. Such mutations exist in prime reproductive years but only have noticeable effects late in life. In old age, when reproduction is not an organism's primary function, accumulating mutations are no longer checked by selection, increasing the risk of disease.

The other, more widely accepted theory of antagonistic pleiotrophy (AP) says that aging occurs when genes that offer help during the reproductive years -- those that produce estrogen, for example -- take on harmful roles later in life. Selection under AP theory favors t
'"/>

Contact: Jim Barlow
b-james3@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
14-Oct-2002


Page: 1 2

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/4/2019)... ... 2019 , ... Orbsen Therapeutics, a biotechnology company focused on ... move its base of operations from the National University of Ireland (NUI) Galway ... in Galway, Ireland. , “With four clinical trials in full swing and the ...
(Date:4/4/2019)... ... April 02, 2019 , ... Researchers from Ambry Genetics ... RNA genetic testing (RGT), as a supplement to DNA genetic testing, improves variant ... poster, is one of 13 presentations at the 2019 American College of Medical ...
(Date:4/1/2019)... ... 2019 , ... uBiome announces the issue of patent number ... Patent and Trademark Office on January 1, 2019 with a priority date of ... Zachary Apte, Dr. Daniel Almonacid, Dr. Jessica Richman, and Dr. Catalina Valdivia, and ...
Breaking Biology News(10 mins):
(Date:3/27/2019)... ... March 27, 2019 , ... In honor of National Nutrition Month, Lajollacooks4u ... of healthy meals and good nutrition. This month, Chef Jodi Abel appeared on ... , The first segment addressed the nutritional value of USDA’s MyPlate, a ...
(Date:3/23/2019)... ... March 22, 2019 , ... uBiome has ... a team of researchers at Nnamdi Azikiwe University in Anambra State, Nigeria led ... PhD, of the Department of Medical Laboratory Sciences and Deputy Provost, College of ...
(Date:3/19/2019)... N.J. (PRWEB) , ... March 19, 2019 , ... The ... is a great opportunity to see the most cutting-edge cancer research. The Visikol team ... with 3D cell culture assays as well as their digital pathology ...
(Date:3/19/2019)... ... March 19, 2019 , ... Bogey was nine years old when he injured both ... left hip. These ailments caused Bogey to experience problems with his mobility. According ... and onto his special spot on the couch. , His owners, devastated at the sight ...
Breaking Biology Technology:
Cached News: