HOME >> BIOLOGY >> NEWS
Study by Israeli scientists provides insight on DNA code

A team of scientists from the Hebrew University of Jerusalem and the Weizmann Institute of Science has revealed the structure of a cellular editor that "cuts and pastes" the first draft of RNA straight after it is formed from its DNA template. Many diseases appear to be tied to mistakes in this process, and understanding the workings of the machinery involved may lead to the ability to correct or prevent them in the future.

Since the discovery, around 25 years ago, that the bits of DNA in the genes that code for protein formation are interspersed with "filler" segments that have no known function, scientists have worked to understand the process by which the right sequences are lifted out and strung together to make a coherent set of instructions. This act, referred to as "RNA splicing," takes place in the "spliceosome" situated in the cell nucleus. A large complex of proteins and short strands of RNA, the spliceosome distinguishes the beginnings and ends of coded segments, precisely cutting and stitching them together. Alternative splicing, which underlies the huge diversity of proteins in the body by allowing segments of the genetic code to be strung together in different ways, takes place in the spliceosome as well.

The team consisted of husband-and-wife scientists Prof. Ruth Sperling of the Genetics Department of the Hebrew University and Prof. Joseph Sperling of the Organic Chemistry Department of the Weizmann Institute; Ruth's graduate student Maia Azubel; and Sharon Wolf of the Chemical Research Support Department at the Weizmann Institute. They produced the most detailed 3-D representation of the spliceosome's structure to date with their study, published in the current edition of the journal Molecular Cell. Rather than follow previous attempts to unravel the workings of the splicing mechanism by studying spliceosomes created in test tubes, they managed to take spliceosomes directly from living cells and examine them under an electron micr
'"/>

Contact: Jerry Barach
jerryb@savion.huji.ac.il
972-2-5882904
The Hebrew University of Jerusalem
9-Sep-2004


Page: 1 2

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study reveals first genetic step necessary for prostate cancer growth
5. Study of flu patients reveals virus outsmarting key drug
6. Study in Science reveals recreational fishing takes big bite of ocean catch
7. Study suggests cell-cycle triggers might be cancer drug targets
8. Study narrows search for genes placing men at increased risk for prostate cancer
9. Study links high carbohydrate diet to increased breast cancer risk
10. Study explains spatial orientation differences between sexes
11. Study suggests humans can speed evolution

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/28/2018)... ... July 28, 2018 , ... ... Kong Polytechnic University (PolyU), has been honoured with the International Association for Wind ... of wind engineering and bridge engineering in research, education, and application. Professor Xu ...
(Date:7/26/2018)... ... July 26, 2018 , ... Shirley Holmlund, an evidence-based ... biofield energy healing treated Vitamin D3 on the strength and health of bones. ... 290% improvement in bone mineralization and over 100% increase in ALP, a bone-specific ...
(Date:7/25/2018)... ... July 25, 2018 , ... A pioneering Duchenne muscular dystrophy clinical trial ... annual Mt. Kinabalu climb to raising awareness of the need to enroll patients. ... with patients and families willing to participate in a clinical trial,” said Catherine Jayasuriya, ...
Breaking Biology News(10 mins):
(Date:8/9/2018)... ... August 09, 2018 , ... Simpson Gumpertz & Heger (SGH) ... building owners and managers for a full-day discussion on health care and life ... Boston for the first time on Thursday, 13 September 2018, at Harvard Medical ...
(Date:8/7/2018)... ... 06, 2018 , ... PetPace , the makers of a smart health-monitoring ... announced the launch of a groundbreaking study to identify and eventually predict problems and ... of pregnant dogs sponsored by PetPace and conducted by Dr. Smadar Tal, DVM, DACT, ...
(Date:7/31/2018)... ... July 31, 2018 , ... Leading regenerative ... methods for extracting and using adipose tissue-derived stem cells to treat or prevent ... While this patent covers Canada specifically, VetStem has been issued similar patents that ...
(Date:7/31/2018)... ... 31, 2018 , ... Mahoney Environmental , a leading ... new website. The new website has been designed with improved functionality and navigation, ... Innovative to build a website created for the customer. The newly redesigned site ...
Breaking Biology Technology:
Cached News: