Study confirms protein culprit in alcohol-induced liver disease

UNC-CH School of Medicine, Chapel Hill-- For the first time, scientists at the University of North Carolina at Chapel Hill have used gene knockout technology to firmly identify a key molecular player in alcohol-induced liver disease . A report of the study appears October 1 in the journal Gastroenterology. The findings carry implications for targeting new treatments aimed at preventing alcohol-induced hepatitis and cirrhosis.

"Having this knock-out technology will help us develop drug therapies for this devastating disease which affects 11 million people in the United States alone," says senior study author Dr. Ronald G. Thurman, professor of pharmacology at UNC-CH School of Medicine.

The report points to tumor necrosis factor-alpha (TNF-alpha) as the liver injury culprit. This hormone-like protein is produced in the liver and cells throughout the body. An immune system cytokine, it is a central pro-inflammatory molecule.

The study offers the first solid proof that TNF-alpha figures importantly in the development of early liver injury associated with long-term alcohol consumption. Previously, higher levels of TNF-alpha were found in alcoholics with hepatitis and laboratory studies have shown that antibodies to TNF-alpha attenuated alcohol-induced liver injury. But the cytokine's role in the disease remained unclear.

"This major increase in our understanding of mechanisms of liver injury brings us one step closer to therapies for alcoholic liver disease," says Dr. Enoch Gordis, director, National Institute on Alcohol Abuse and Alcoholism, a component of the National Institutes of Health.

Thurman explains the production of TNF-alpha in the liver occurs in phagocytes called Kupffer cells. These white cells help kill bacteria , including endotoxin - pieces of raw, gram-negative bacteria that get into the liver via the intestines. Studies suggest that alcohol intake increases the gut's permeability, thus releasing increas

Contact: Lynn Wooten
University of North Carolina School of Medicine

Page: 1 2

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:

(Date:7/22/2020)... ... 21, 2020 , ... USDM Life Sciences , a ... a new solution to manage regulated workloads on Microsoft Azure. , Regulated biotechnology, ... complies with FDA and global regulations. USDM's new managed service for regulated workloads ...
(Date:7/4/2020)... ... July 03, 2020 , ... ... outstanding recognition and multiple awards for not only the products and treatments developed, ... Skincare and Vivace® Microneedle RF. All the brands built by ABM have received ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... for biopharmaceutical R&D, today announced that it has entered into a multi-year ... antibodies (Multiclonics®), to support their translational and clinical research strategy to discover ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... July 09, 2020 , ... Sentien Biotechnologies, ... the hiring of Allen R. Nissenson, M.D., F.A.C.P., as its Chief Medical Officer. ... of Sentien’s lead product, SBI-101. Dr. Nissenson serves as an Emeritus Professor ...
(Date:7/1/2020)... ... June 29, 2020 , ... MedShift ... 40% in 2020, despite many obstacles created as a result of COVID-19. As ... for its partnered medical practices and medical manufacturers by expanding access to device ...
(Date:6/28/2020)... ... June 25, 2020 , ... The Indoor Lab, a leading provider ... for businesses of all types to ensure cleanliness, distancing and occupancy with its patent ... Safe Space™ enabled business will provide a health performance index system that scores all ...
(Date:6/28/2020)... ... June 26, 2020 , ... The ... providers, today announced its strong opposition to the recently introduced bicameral Facial ... blanket ban on most federal use of nearly all biometric and related image ...
Breaking Biology Technology:
Cached News: