Study demonstrates altered angiogenic proteins in preeclampsia patients

BOSTON -- The discovery that a protein "marker" is sharply elevated approximately five weeks prior to the onset of preeclampsia could provide a warning sign to help doctors in diagnosing this potentially life-threatening complication of pregnancy. Led by researchers at Beth Israel Deaconess Medical Center (BIDMC) and the National Institute of Child Health and Development (NICHD), the study appears in the February 12 issue of The New England Journal of Medicine.

Preeclampsia typically develops after the 20th week of pregnancy and is characterized by high blood pressure, edema and protein in the urine. However, in severe cases, it can without warning rapidly escalate to eclampsia, a condition in which the mother suffers serious and potentially fatal seizures. There are currently no blood tests available to help physicians diagnose these patients prior to the onset of clinical symptoms.

"Our new findings might allow doctors to closely monitor these high-risk patients and identify preeclampsia at an earlier stage," explains co-senior author S. Ananth Karumanchi, MD, of the Renal Division at BIDMC and Assistant Professor of Medicine at Harvard Medical School (HMS). Also known as toxemia, preeclampsia occurs in an estimated five percent of all pregnancies, and affects approximately 200,000 women in the U.S. each year. Worldwide, it is one of the leading causes of maternal and infant mortality.

Last year, Karumanchi and colleagues identified the source of the disease as being a protein known as soluble fms-like tyrosine kinase 1 (sFlt1). Released by the mother's placenta, sFlt1 is believed to trigger the symptoms of preeclampsia when it binds to and "mops up" another group of proteins placental growth factor (PGF) and vascular endothelial growth factor (VEGF). PGF and VEGF exist to promote angiogenesis, the growth of small blood vessels.

"What appears to be happening [in cases of preeclampsia] is that blood vessels to the placenta become n

Contact: Bonnie Prescott
Beth Israel Deaconess Medical Center

Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:

(Date:10/11/2018)... ... October 11, 2018 , ... The American College of Medical ... Flatley Brennan, RN, PhD, Director of the National Library of Medicine (NLM), during the ... Annual Symposium is taking place Nov. 3 – 7. , In honor of Morris ...
(Date:10/5/2018)... ... October 04, 2018 , ... CallTower Inc., ... was present at Microsoft Ignite 2018, in Orlando, Florida, when Microsoft made a ... a statement about the new direction of Skype for Business Online, outlining the ...
(Date:10/5/2018)... ... October 04, 2018 , ... High dose of biotin may cause ... such as cardiac troponin has serious clinical complications. There is an increasing trend of ... still unknown. , High dose of biotin supplement use may continue to increase ...
Breaking Biology News(10 mins):
(Date:10/16/2018)... ... October 15, 2018 , ... Since the inception of ... slides by eye wherein key features are used for classification. While this type ... is highly limited in that it is a qualitative and low-throughput approach where ...
(Date:10/11/2018)... ... October 11, 2018 , ... Avery Products Corp., the ... collaboration with HP, the global leader in printing, has obtained the British Standard ... all HP PageWide Printers. , The award-winning Avery UltraDuty GHS Chemical Labels, combined ...
(Date:10/3/2018)... ... , ... Milwaukee Area Technical College (MATC), a public, two-year comprehensive technical college, ... Room T129 in the T Building, 101 N. 6th St., to introduce area students, ... and formal program will be held at 4 p.m. , MATC recently added new ...
(Date:9/29/2018)... , ... September 29, 2018 , ... ... enabling mid-level and early-stage companies to access the power of influence analytics and ... solutions available to a broader market that didn’t necessarily have access to the ...
Breaking Biology Technology:
Cached News: