HOME >> BIOLOGY >> NEWS
Study finds direction of enzymes affects DNA repair

DNA repair enzymes do a much better job of repairing damaged genes if they are facing in one direction instead of the other. This and other details of how DNA repair is performed are reported in the online version of the journal Proceedings of the National Academy of Sciences by researchers at Washington State University and the National Institute of Environmental Health Sciences.

According to the new study, the repair enzymes "distinguish" between various positions and may be two to three times as effective, depending on whether the damage to be repaired is facing "toward" or "away from" the nucleosome, the protein-DNA complex that folds the very long DNA strands into the tiny nucleus of a cell and gives enzymes access to the DNA for repair and for replication when the cell divides.

Washington State's senior author, Michael J. Smerdon, explained, "Like a child's face, our DNA gets smudged up all the time by environmental and bodily chemicals. Our work provides additional details about how our cells work to clean the DNA up - to correct our heredity molecule, the DNA helix that is within each living cell." The explosion of research on DNA repair dates back less than a decade, to the demonstration that some colon cancer and xeroderma pigmentosum are linked to faulty DNA repair. Xeroderma pigmentosum is a rare condition in which the skin is extremely sensitive to the sun and other ultraviolet light, resulting in extreme freckling and aging.

A key element of the report is the finding of a strong "down-regulation" of one of the repair enzymes, DNA polymerase (pol ) in the presence of the nucleosome. This means that nucleosome formation on DNA can inhibit base excision repair of a nucleosome-sequestered DNA lesion. Such down-regulation could have huge biological implications, since repair of such DNA damage will be blocked at the pol step. Such a blocking of repair will ultimately lead to mutations or other genomic instability or
'"/>

Contact: Bill Grigg
grigg@niehs.nih.gov
301-402-3378
NIH/National Institute of Environmental Health Sciences
23-Jun-2003


Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: