Study finds first evidence COX-2 enzymes can regulate DNA damage

Scientists from the University of Pennsylvania's Center for Cancer Pharmacology report the first evidence that cylcooxygenase-2 enzymes (known as COX-2) are not only responsible for pain and inflammation but that they are also involved in causing the DNA damage associated with cancer.

Dr. Ian Blair reports this study for the first time on June 15th at the Annual Meeting of the American Society for Biochemistry and Molecular Biology (ASBMB)/8th International Union of Biochemistry and Molecular Biology Conference (IUBMB) in Boston. His research team's discovery casts a new light on the mechanism through which aspirin - and diets rich in fruits, grain and vegetables -- appear to lower the risk of some cancers. It also suggests a potential role for the widely used COX-2 inhibitors in the prevention of DNA damage.

In the same presentation, Dr. Blair reports new data that support his earlier discovery that vitamin C can increase DNA damage. His 2001 article in Science was the first to report a potential negative effect of vitamin C and thus caused a firestorm of attention, although Dr. Blair was careful to spell out that he believed that in order to be at risk for DNA damage from vitamin C an individual would have to take some unknown high quantity of the vitamin, experience oxidative stress, and have a problem with the ordinarily efficient DNA repair enzymes. The two studies are closely related, says Dr. Blair, because the COX-2 enzyme produces lipid hydroperoxides and vitamin C stimulates their breakdown. This results in the formation of a class of DNA-harming agents called genotoxins, which are known to be involved in the formation of certain human cancers.

Interest in the potential use of COX-2 inhibitors as anticancer agents was fueled in part a decade ago when an American Cancer Society study showed that regular use of aspirin led to an unexpectedly low incidence of colon cancer. But all was not rosy. In additi

Contact: Sarah Goodwin
Federation of American Societies for Experimental Biology

Page: 1 2 3

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:

(Date:10/8/2019)... ... October 08, 2019 , ... ... that make it easier than ever for businesses and organizations to use their ... App enables organizations to count down to or count up from date-related milestones, ...
(Date:10/3/2019)... ... October 01, 2019 , ... ... dispensing of chemicals, reagents, and medias and to be a more environmentally sustainable ... the culmination of years of experience and feedback from the original version we ...
(Date:9/30/2019)... ... 30, 2019 , ... As human induced pluripotent stem cells (hiPSCs) move closer ... and diseases of the human heart, there is an increasing need for stable stem ... to be clearly and easily recorded. A study released today in STEM CELLS details ...
Breaking Biology News(10 mins):
(Date:9/17/2019)... STATION, N.J. (PRWEB) , ... September 16, 2019 , ... ... clearing reagents and kits that allow for the complete 3D characterization of tissues through ... Visikol has transitioned into an imaging, image analysis and advanced cell culture focused contract ...
(Date:9/11/2019)... Pa. (PRWEB) , ... September 09, 2019 , ... ... for life sciences companies and government agencies, announced that its president and CEO ... group of successful business leaders. , The Forbes Council accepted Gallivan based on ...
(Date:9/11/2019)... SOMERSET, N.J. (PRWEB) , ... September 10, 2019 ... ... technologies, development, and manufacturing solutions for drugs, biologics, gene therapies, and consumer health ... Pharma Forum, to be held at the Bausparkasse Schwäbisch Hall AG, Schwabisch Hall, ...
(Date:9/8/2019)... ... September 05, 2019 , ... ... Fitzgerald, former Vice President of Finance for Shopify, has been named Chief Financial ... healthcare venture capitalist Joel Finlayson as strategic advisors. Additionally, Spartan has hired Steve ...
Breaking Biology Technology:
Cached News: