HOME >> BIOLOGY >> NEWS
Study finds genetic aberrations linked to lung cancer; Could help in early diagnosis

COLUMBUS, Ohio - Researchers at Ohio State University have identified more than two dozen genes that behave abnormally in cancerous lung cells. The finding could lead to new tests for diagnosing lung cancer.

Led by Ming You, a professor of molecular virology, immunology and medical genetics, the researchers found 14 genes that are over-expressed - meaning they are too active - in lung cells stricken by cancer. They also identified 12 genes that are under-expressed (not active enough) in these cells.

You and his colleagues reported their findings in a recent issue of the journal Neoplasia. About half of the 26 genes pinpointed in the study have never been linked to lung cancer before.

"In the past five years, lung cancer has killed more people in the U.S. than breast cancer, prostate cancer and colon cancer combined," You said. "We must find methods for early detection of the disease."

For the study, You and his colleagues analyzed samples of cancerous lung tissue taken from patients who had died of the ailment. (Some of these victims had been heavy smokers and one had suffered exposure to asbestos.) The researchers compared the samples to normal lung tissue from the same patients.

Using standard tests, the researchers found that the level of certain proteins in the tumor cells was higher than normal. They traced the increased level of these proteins to the over-expression of 14 genes. In the same way, the researchers traced the low level of another set of proteins to 12 genes that were under-expressed in the tumor cells.

Among the genes identified in the study are ones that regulate intra-cellular communication, cell growth and apoptosis, or programmed cell death. The list includes some known oncogenes - genes that promote cancer when they go into overdrive - and some known tumor-suppressor genes, which fail to check tumor growth when they are under-ex
'"/>

Contact: Ming You
You.21@osu.edu
614-247-7430
Ohio State University
14-Jun-2002


Page: 1 2

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
(Date:8/28/2014)... FASEB MARC (Maximizing Access to Research Careers) Program ... Genetics Society of America,s 27th Annual Mouse Molecular ... 2014 in Pacific Grove, California. These awards ... post doctorates and scientists from underrepresented groups into ... to encourage the participation of young scientists at ...
(Date:8/28/2014)... (Maximizing Access to Research Careers) Program has announced ... of Sports Medicine,s Conference on Integrative Physiology of ... These awards are meant to promote the ... underrepresented groups into the mainstream of the basic ... young scientists at the American College of Sports ...
(Date:8/28/2014)... in German . ... with the help of sophisticated assembly lines. Mobile assembly carriers, ... part of these assembly lines. In the case of a ... stages arranged in a precise spatial and chronological sequence, resulting ... , The creation of such an assembly line at molecular ...
Breaking Biology News(10 mins):Nanoscale assembly line 2Nanoscale assembly line 3
(Date:8/28/2014)... 2014  Next month, executives from clinical trial marketing firm ... beginning with Patient-Centered Clinical Trials 2014 , to be ... , September 4-5. Patient recruitment experts Bonnie A. ... will share insights on the benefits of employing an ... – from media to mobile apps – can be used ...
(Date:8/28/2014)... Exciting new work by a Florida State University research ... can take your temperature, emit white light, and convert ... molecule looks like a butterfly. , Biwu Ma, associate ... in the FAMU-FSU College of Engineering, created the molecule ... continued to discover that his creation has many other ...
(Date:8/28/2014)... 2014 PrimeSource Building Products, Inc., ... SoundConnect to support their communication needs ... and web conferencing platform GlobalMeet powered by SoundConnect. ... needs. SoundConnect delivers award winning “results driven” ... Products will be utilizing GlobalMeet powered by ...
(Date:8/27/2014)... Green & Grow Inc. (GGI) has ... and secured Otter Capital as a significant new partner. ... of GGI’s Agriplier™ technology, building on recent compelling field ... our first meeting, we have been impressed with Otter ... said Alan Sobba, President and CEO of GGI. “We ...
Breaking Biology Technology:BBK Worldwide Leads Sessions at Key September Events 2Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2PrimeSource Chooses SoundConnect as Collaboration Provider 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3
Cached News: