This study best exemplifies the potential benefits of translational physiology, demonstrating that research performed in the laboratory has immediate benefits to the diagnosis and treatment of a wide range of chronic disorders that afflict Americans.
Presently, amiloride is not considered a first-option treatment for hypertensive patients. These findings will enable caregivers to target those patients who suffer from this deadly condition that will benefit from pharmaceutical products now available.
Findings Have High Impact for Research Overall
This research marks a new direction in physiology research. These investigators adhered to the principles of translational physiology, known as the transfer of knowledge gained from basic research to new and improved methods of preventing, diagnosing, or treating disease, as well as the transfer of clinical insights into hypotheses that can be tested and validated in the basic research laboratory. This process occurs from the bench to the bedside, as well as from the bedside back to the bench.