HOME >> BIOLOGY >> NEWS
Study identifies new protein on neurons that may be useful as survival/growth factor

Tampa, FL (March 27, 2002) Researchers at the University of South Florida's Roskamp Institute have identified an immune molecule, CD40, on the surface of neurons that appears to promote both neuron development and protection. The finding is a first step in defining the role of CD40 in the brain at different stages of life and evaluating its usefulness in helping neurons survive.

The study is published in the latest March issue of the journal European Molecular Biology Organization.

In the bloodstream, the interaction between the protein receptor CD40 and another protein, CD40 ligand (CD40L), allows white cells to trigger antibody production and to activate cellular immunity. This immune response helps neutralize foreign invaders, such as bacteria and viruses. However, in an earlier study, the USF reseachers found that when this same CD40-CD40L signaling system is triggered in the brain, the immune response can cause microglia damage to neurons.

This latest study demonstrates for the first time that CD40 is produced and displayed on the surface of neurons in the brain. It also attempts to answer the question: What is the purpose of CD40 on neurons?

The researchers came up with two answers. First, they found that adding CD40L to immature neurons caused these primitive cells with few connecting branches to mature into neurons with widespread branches suitable for making connections to other neurons.

Secondly, in the presence of CD40L, neurons with CD40 on their surface were much more likely to resist injury than neurons not given CD40.

What the researchers found in the test tube also was borne out in transgenic mice deficient in CD40. The brains of these older, CD40-deficient mice showed signs of degeneration and the mice demonstrated gross central nervous system abnormalties with age.

"These effects suggest that the CD40 signaling on neurons plays a physiological role in normal neuronal cell maintenance
'"/>

Contact: Anne DeLotto Baier
abaier@hsc.usf.edu
813-974-3300
University of South Florida Health
28-Mar-2002


Page: 1 2

Related biology news :

1. Study: Emission of smog ingredients from trees is increasing rapidly
2. Study explores gene transfer to modify underlying course of Alzheimers disease
3. Study reveals why eyes in some paintings seem to follow viewers
4. Study by Israeli scientists provides insight on DNA code
5. Study reveals first genetic step necessary for prostate cancer growth
6. Study of flu patients reveals virus outsmarting key drug
7. Study in Science reveals recreational fishing takes big bite of ocean catch
8. Study suggests cell-cycle triggers might be cancer drug targets
9. Study narrows search for genes placing men at increased risk for prostate cancer
10. Study links high carbohydrate diet to increased breast cancer risk
11. Study explains spatial orientation differences between sexes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/7/2020)... , ... August 06, 2020 , ... ... participate in the prestigious National STEM Scholar Program, a unique professional development program ... and project support for middle school science teachers nationwide. , Created in partnership ...
(Date:7/31/2020)... ... July 30, 2020 , ... Justin Zamirowski to lead ... near term focus on Type 2 diabetes and associated comorbidities. , Justin brings ... areas and classes. As Chief Commercial Officer, Justin will lead Better Therapeutics’ ...
(Date:7/10/2020)... CHURCH, Va. (PRWEB) , ... July 08, 2020 ... ... The Latest on Cell and Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July ... may need a comparability study, but what is the most effective way to ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... ... August 03, 2020 , ... Introducing Ardent Animal Health – MediVet Biologics rebrands ... , Known as MediVet Biologics since its formation in 2016, the company is ... Animal Health will build on its base of innovative therapies for osteoarthritis and cancer. ...
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, ... its new tagline, “BUILDING FOR LIFE.” The adoption of this taglines comes at ... requiring fast track capacity to provide patients with urgently needed vaccines and other ...
(Date:7/31/2020)... ... July 29, 2020 , ... Anomet Products has introduced ... materials for use with CRM, neurostimulation, vascular, and related devices. , Anomet ... design requirements, performance, and cost criteria; especially where solid wire is limited. Typical ...
(Date:7/31/2020)... ... 29, 2020 , ... eSource has long been touted as the solution to ... of eSource, the reasons it did not take off as quickly as people initially ... industry is moving towards capturing data electronically for clinical trials and then repurposing it ...
Breaking Biology Technology:
Cached News: