Study identifies new source of stem cells

Montreal, August 13, 2001. A new study from the Montreal Neurological Institute (MNI) of McGill University has identified a non-controversial source of stem cells that can produce a number of different cell types, including the type of neural cells needed to potentially help patients recover from a spinal cord injury or Parkinsons disease.

These findings are published today on-line in the highly cited scientific journal Nature Cell Biology in an article entitled "Isolation of Multipotent Adult Stem Cells from the Dermis of Mammalian Skin" by J.G. Toma, M. Akhavan, K.J.L. Fernandes, F. Barnab-Heider, A. Sadikot, D.R. Kaplan, and F.D. Miller. The paper can be viewed on line at http://www.nature.com/ncb/future_issues/.

Dr. Freda Miller and colleagues at the Centre for Neuronal Survival and the Brain Tumour Research Centre at the Montreal Neurological Institute, McGill University, have isolated stem cells from the dermis of adult rodents that will proliferate and differentiate in culture to produce very different cell types- neurons, glia, smooth muscle cells, and fat cells. These novel stem cells, SKPs, were isolated from the skin of juvenile and adult rodents- an accessible nonembryonic source. Human studies have indicated that similar cells are present in adult human skin. "We believe our discovery is important as we have identified an exciting new stem cell from a non-controversial source that holds considerable promise for scientific and therapeutic research," says Dr. Freda Miller.

The work conducted at the MNI has led Dr. Miller and her colleagues to offer a new account of stem cells present in the adult. "SKPs represent a novel multipotent stem cell less biased than other adult stem cells they have the ability to differentiate into diverse cell types of different embryonic lineage and can be cultured for one year without losing this ability," explains Dr. Miller. "This is extremely significant as rather than being programmed to ge

Contact: Sandra McPherson
McGill University

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